Mechanistic studies of morphine dehydrogenase and stabilization against covalent inactivation

Biochemical Journal

Volumn 345, Issue 3, 2000, Pages 687-692

  Walker, Edward H ^a,b   French, Christopher E ^a,c   Rathbone, Deborah A ^a   Bruce, Neil C ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b Laboratory of Molecular Biology   (United Kingdom)

^c UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

Biocatalysis; Dehydrogenases; Opiates; Protein engineering

Indexed keywords

CODEINE; CYSTEINE; DRUG METABOLIZING ENZYME; MORPHINE; MORPHINE DEHYDROGENASE; OXIDOREDUCTASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; CONTROLLED STUDY; DRUG METABOLISM; ENZYME INACTIVATION; ENZYME KINETICS; ENZYME MECHANISM; ENZYME SPECIFICITY; ENZYME STABILITY; ENZYME STRUCTURE; NONHUMAN; OXIDATION; PRIORITY JOURNAL; REDUCTION; SEQUENCE HOMOLOGY; SITE DIRECTED MUTAGENESIS; STRUCTURE ACTIVITY RELATION;

EID: 0034141946     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3450687     Document Type: Article

References (34)

1. Bruce, N. C., Wilmot, C. J., Jordan, K. N., Trebilcock, A. E., Gray Stephens, L. D. and Lowe, C. R. (1990) Arch. Microbiol. 154, 465-470
2. Bruce, N. C., Wilmot, C. J., Jordan, K. N., Gray Stephens, L. D. and Lowe, C. R. (1991) Biochem. J. 274, 875-880
3. Willey, D. L., Caswell, D. A., Lowe, C. R. and Bruce, N. C. (1993) Biochem. J. 290, 539-544
4. Hailes, A. M. and Bruce, N. C. (1993) Appl. Environ. Microbiol. 59, 2166-2170
5. French, C. E. and Bruce, N. C. (1994) Biochem. J. 301, 97-103
6. French, C. E. and Bruce, N. C. (1995) Biochem. J. 312, 671-678
7. Holt, P.-J., Gray Stephens, L. D., Bruce, N. C. and Lowe, C. R. (1995) Biosens. Bioelectron. 10, 517-526
8. Holt, P.-J., Bruce, N. C. and Lowe, C. R. (1996) Anal. Chem. 68, 1877-1882
9. Bruce, N. C., Caswell, D. A., French, C. E., Hailes, A. M., Long, M. T. and Willey, D. L. (1994) Ann. N. Y. Acad. Sci. 721, 85-99
10. French, C. E., Hailes, A. M., Rathbone, D. A., Long, T. M., Willey, D. L. and Bruce, N. C. (1995) Bio/Technology 13, 674-676
11. Bruce, N. C., French, C. E., Hailes, A. M., Long, M. T. and Rathbone, D. A. (1995) Trends Biotechnol. 13, 200-205
12. Bruce, N. C., Willey, D. L. Coulson, A. F. W. and Jeffery, J. (1994) Biochem. J. 299, 805-811
13. Wilson, D. K., Bohren, K. M., Gabbay, K. H. and Quiocho, F. A. (1992) Science 257, 81-54
14. Borhani, D. W., Harter, T. M. and Petrash, J. M. (1992) J. Biol. Chem. 267, 24841-24847
15. Orr, G. A. and Blanchard, J. S. (1984) Anal. Biochem. 142, 232-234
16. Leatherbarrow, R. J. (1990) GraFit version 2.0. Erithacus Software Ltd., Staines, U.K.
17. Birdsall, B. (1983) Anal. Biochem. 132, 353-361
18. Bradshaw, C. W., Hummel, W. and Wong, C.-H. (1992) J. Org. Chem. 57, 1532-1536
19. Arnold, L. J. (1976) Biochemistry 15, 4844-4849
20. Neville, G. A., Ekiel, I. and Smith, I. C. P. (1987) Magn. Reson. Chem. 25, 31-35
21. Feldman, H. B. (1977) Biochim. Biophys. Acta 480, 14-20
22. Bjorkheim, I. and Danielsson, H. (1970) Eur. J. Biochem. 12, 80-84
23. Askonas, L. J., Ricigliano, J. W. and Penning, T. M. (1991) Biochem. J. 278, 835-841
24. Cleland, W. W. (1970) in The Enzymes, 3rd edn., (Boyer, P. D., ed.). vol. 2, pp. 1-65, Academic Press Inc., New York
25. Grimshaw, C. E., Shahbaz, M. and Putney, C. G. (1990) Biochemistry 29, 9936-9955
26. Kubieski, T. J., Hyndman, D. J., Morjana, M. A. and Flynn, T. G. (1992) J. Biol. Chem. 267, 6510-6517
27. Bhatnagar, A., Das, B., Gavva, S. R., Cook, P. F. and Srivastava, S. K. (1988) Arch. Biochem. Biophys. 261, 264-274
28. Bohren, K. M., Grimshaw, C. E., Lai, C.-J., Harrison, D. H., Ringe, D., Petsko, G. A. and Gabbay, K. H. (1994) Biochemistry 33, 2021-2032
29. Tarie, I., Borhani, D. W., Wilson, D. K., Quiocho, F. A. and Petrash, J. M. (1993) J. Biol. Chem. 268, 25687-25693
30. Bohren, K. M., Page, J. L., Shankar, R., Henry, S. P. and Gabbay, K. H. (1991) J. Biol. Chem. 266, 24031-24037
31. Rapoport, H., Baker, D. R. and Reist, H. N. (1957) J. Org. Chem. 15, 1489-1492
32. Nagamatsu, K., Kido, Y., Terao, T., Ishida, T. and Toki, S. (1982) Life Sci. 30, 1121-1127
33. Kumagai, Y., Todaka, T. and Toki, S. (1990) J. Pharmocol. Exp. Ther. 255, 504-510
34. Ricigliano, J. W. and Penning, T. M. (1990) Biochem. J. 269, 749-755