Cell-mediated DNA transport between distant inflammatory sites following intradermal DNA immunization in the presence of adjuvant

Journal of Immunology

Volumn 164, Issue 3, 2000, Pages 1340-1345

  La Cava, Antonio ^a,g   Billetta, Rosario ^a,e   Gaietta, Guido ^b   Bonnin, Dustan B ^a   Baird, Stephen M ^c   Albani, Salvatore ^d,f  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^e UNIVERSITY OF CHILE   (Chile)

^f Androclus Therapeutics   (Italy)

^g SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; AUTOIMMUNITY; CELLULAR IMMUNITY; FLUORESCENCE IN SITU HYBRIDIZATION; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNIZATION; IMMUNOMODULATION; INFLAMMATORY CELL; LYMPHOID TISSUE; PLASMID; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SKIN INFLAMMATION; SOUTHERN BLOTTING;

EID: 0034141872     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.164.3.1340     Document Type: Article

References (35)

1. Pisetsky, D. S. 1996. The immunological properties of DNA. J. Immunol. 156: 421.
2. Ulmer, J. B., J. J. Donnelly, S. E. Parker, G. H. Rhodes, P. L. Felgner, V. J. Dwarki, S. W. Gromkowski, R. Randall Deck, C. M. DeWitt, A. Friedman. et al. 1993. Heterologous protection against influenza by injection of DNA encoding a viral protein. Science 259:1745.
3. Michel, M. L., H. L. Davis, M. Schleef, M. Mancini, P. Tiollais, and R. G. Whalen. 1995. DNA-mediated immunization to the hepatitis B surface antigen in mice: aspects of the humoral response mimic hepatitis B viral infection in humans. Proc. Natl. Acad. Sci. USA 92:5307.
4. Donnelly, J. J., J. B. Ulmer, J. W. Shiver, and M. A. Liu. 1997. DNA vaccines. Annu. Rev. Immunol. 15:617.
5. Feltquate, D. M., S. Heaney, R. G. Webster, and H. L. Robinson. 1997. Different T helper cell types and antibody isotypes generated by saline and gene gun DNA immunization. J. Immunol. 158:2278.
6. Boyle, J. S., A. Silva, J. L. Brady, and A. M. Lew. 1997. DNA immunization: induction of higher avidity antibody and effect of route on T cell cytotoxicity. Proc. Natl. Acad. Sci. USA 94:14626.
7. Robinson, H. L., and C. A. Torres 1997. DNA vaccines. Semin. Immunol. 9:271.
8. Yokoyama, M., D. E. Hassett, J. Zhang, and J. L. Whitton. 1997. DNA immunization can stimulate florid local inflammation, and the antiviral immunity induced varies depending on injection site. Vaccine 15:553.
9. Danko, I., P. Williams, H. Herweijer, G. Zhang, J. S. Latendresse, I. Bock, and J. A. Wolff. 1997. High expression of naked plasmid DNA in muscles of young rodents. Hum. Mol. Genet. 6:1435.
10. Corr, M., D. J. Lee, D. A. Carson, and H. Tighe. 1996. Gene vaccination with naked plasmid DNA: mechanism of CTL priming. J. Exp. Med. 184:1555.
11. Robinson, H. L., S. Lu, D. M. Feltquate, C. A. T. Tones, J. Richmond, C. M. Boyle, M. J. Morin, J. C. Santoro, R. G. Webster, D. Monteflori, et al. 1996. DNA vaccines. AIDS Res. Hum. Retroviruses 12:455.
12. Raz, E., D. A. Carson, S. E. Parker, T. B. Parr, A. M. Abai, G. Aichinger, S. H. Gromkowski, M. Singh, D. Lew, M. A. Yankauckas, et al. 1994. Intradermal gene immunization: the possible role of DNA uptake in ihe induction of cellular immunity to viruses. Proc. Natl. Acad. Sci. USA 91:9519.
13. Condon, C., S. C. Watkins, C. M. Celluzzi, K. Thompson, and L. D. Falo. 1996. DNA-based immunization by in vivo transfection of dendritic cells. Nat. Med. 2:1122.
14. Torres, C. A., A. Iwasaki, B. H. Barber, and H. L. Robinson. 1997. Differential dependence on target site tissue for gene gun and intramuscular DNA immunizations. J. Immunol. 158:4529.
15. Iwasaki, A, C. A. Torres, P. S. Ohashi, H. L. Robinson, and B. H. Barber. 1997. The dominant role of bone marrow-derived cells in CTL induction following plasmid DNA immunization at different sites. J. Immunol. 159:11.
16. Lu, B., G. Scott, and L. A. Goldsmith. 1996. A model for keratinocyte gene therapy: preclinical and therapeutical considerations. Proc. Assoc. Am. Physicians 108:165.
17. 17: Tighe, H., M. Corr, M. Roman, and E. Raz. 1998. Gene vaccination: plasmid DNA is more than just a blueprint. Immunol. Today 19:89.
18. Steinman, R. M. 1991. The dendritic cell system and its role in immunogenicity. Annu. Rev. Immunol. 9:271.
19. Larsen, C. P., R. M. Steinman, M. Witmer-Pack, D. F. Hankins, P. J. Morris, and J. M. Austyn. 1990. Migration and maturation of Langerhans cells in skin transplants and explants. J. Exp. Med. 172:1483.
20. Doe, B., M. Selby, S. Barnett, J. Baenziger, and C. M. Walker. 1996. Induction of cytotoxic T lymphocytes by intramuscular immunization with plasmid DNA is facilitated by bone marrow-derived cells. Proc. Natl. Acad. Sci. USA 93:8578.
21. + T cells after gene gun immunization. J. Exp. Med. 188:1075.
22. Chattergoon, M. A., T. M. Robinson, J. D. Boyer, and D. B. Weiner. 1998. Specific immune induction following DNA-based immunization through in vivo transfection and activation of macrophages/antigen presenting cells. J. Immunol. 160:5707.
23. Pollack, Y., R. Stein, A. Razin, and H. Cedar. 1980. Methylation of foreign DNA sequences in eukaryotic cells. Proc. Natl. Acad. Sci. USA 77:6463.
24. Coligan, J. E. A. M. Kruisbeek, D. H. Margulies, E. M. Shevach, and W. Strober. 1993. Current Protocols in Immunology. J. Wiley & Sons, New York.
25. Hengge, U. R., P. S., Walker, and J. C. Vogel. 1996. Expression of naked DNA in human, pig, and mouse skin. J. Clin. Invest. 97:2911.
26. Patterson, B. K., M. Till, P. Otto, C. Goolsby, M. R. Furtado, L. J. McBride, and S. M. Wolinsky. 1993. Detection of HIV-I DNA and messenger RNA in individual cells by PCR-driven in situ hybridization and flow cytometry. Science 260:976.
27. Kripke, M. L., C. G. Munn, A. Jeevan, J. M. Tang, and C. Bucana. 1990. Evidence that cutaneous antigen-presenting cells migrate to regional lymph nodes during contact sensitization. J. Immunol. 145:2833.
28. Weinlich, G., M. Heine; H. Stossel, M. Zanella, P. Stoitzner, U. Ortner, J. Smolle, F. Koch, N. T. Sepp, G. Schuler, and N. Romani. 1998. Entry into afferent lymphatics and maturation in situ of migrating murine cutaneous dendritic cells. J. Invest. Dermatol. 110:441.
29. Schubbert, R., D. Rent, B. Schmitz, B., and W. Doerfler. 1997. Foreign (M13) DNA ingested by mice reaches peripheral leukocytes, spleen, and liver via the intestinal wall mucosa and can be covalently linked to mouse DNA. Proc. Natl. Acad. Sci. USA 94:961.
30. Issekutz, A. C., and T. B. Issekutz. 1992. The contribution of LFA-1 (CD11a/ CD18) and Mac-1 (CD11b/CD18) to the in vivo migration of polymorphonuclear leukocytes to inflammatory reactions in the rat. Immunology 76:655.
31. Issekutz, A. C., and T. B. Issekutz. 1995. Monocyte migration to arthritis in the rat utilizes both CD11/CD18 and very late activation antigen 4 integrin mechanisms. J. Exp. Med. 181:1197.
32. Tang, T., A. Rosenkranz, K. J. M. Assmann, M. J. Goodman, J.-C. Gutierrez-Ramos, M. C. Carroll, R. S. Cotran, and T. N. Mayadas. 1997. A role for Mac-1 (CD11b/CD18) in immune complex-stimulated neutrophil function in vivo: Mac-1 deficiency abrogates sustained Fc receptor-dependent neutrophil adhesion and complement-dependent:proteinuria in acute glomerulonephritis. J. Exp. Med. 186:1853.
33. 4-integrin supports leukocyte rolling and adhesion in chronically inflamed postcapillary venules in vivo. J. Exp. Med. 183:1995.
34. Langermann, S. 1998. Site-directed immunogenesis. Nat. Med. 4:547.
35. Song, X., M. Gu, W. Jin, D. M. Klinman, and S. M. Wahl. 1998. Plasmid DNA encoding transforming growth factor-β1 suppresses chronic disease in a streptococcal cell wall-induced arthritis model. J. Clin. Invest. 101:2615.