Nature of the postsynaptic action of crotoxin at guinea-pig diaphragm end-plates

Journal of Natural Toxins

Volumn 9, Issue 1, 2000, Pages 33-42

  Brazil, Oswaldo Vital ^a   Fontana, Marcos Dias ^a   Heluany, Nadim F ^a  

^a UNIVERSITY OF CAMPINAS   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOPYRIDINE; CARBACHOL; CROTOXIN;

ANIMAL; ARTICLE; DIAPHRAGM; DOSE RESPONSE; DRUG EFFECT; ELECTROPHYSIOLOGY; GUINEA PIG; INNERVATION; PHYSIOLOGY; SMOOTH MUSCLE; SYNAPTIC TRANSMISSION;

4-AMINOPYRIDINE; ANIMALS; CARBACHOL; CROTOXIN; DIAPHRAGM; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHYSIOLOGY; GUINEA PIGS; MUSCLE, SMOOTH; SYNAPTIC TRANSMISSION;

ANIMALIA; CAVIA PORCELLUS; ELECTROPHORUS ELECTRICUS; MAMMALIA; MARMORATA; SUS SCROFA; TORPEDO MARMORATA;

EID: 0034141263     PISSN: 10588108     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Bon, C., Changeux, J. P., Jeng, T. W., and Fraenkel-Conrat, H. (1979). Postsynaptic effects of crotoxin and of its isolated subunits. Eur. J. Biochem. 99, 471-481.
2. Chang, C. C., and Dong Lee, J. (1977). Crotoxin, the neurotoxin of South American rattlesnake venom, is a piesynaptic toxin like β-bungarotoxin. Naunyn-Schmiedeberg's Arch. Pharmacol. 296, 159-168.
3. Changeux, J. P. (1981). Acetylcholine receptor. An "allosteric" membrane protein. Harvey Lectures, Series 75, 85-254.
4. Datyner, M. E., and Gage, P. W. (1973). Presynaptic and postsynaptic effects of the venom of the Australian tiger snake at the neuromuscular junction. Br. J. Pharmacol. 49, 340-354.
5. Durant, N. N., and Marshall, I. G. (1978). The effects of 3,4-diaminopyridine on spontaneous and evoked transmitter release at the frog neuromuscular junction. J. Physiol. (London) 280, 21 p.
6. Heidmann, T., Oswald, R. E., and Changeux, J. P. (1983). Multiple sites of action for noncompetitive blockers on acetylcholine receptor-rich membrane fragments from Torpedo marmorata. Biochemistry 22, 3112-3127.
7. Jacobs, R. S., and Burley, E. S. (1978). Nerve terminal facilitatory action of 4-aminopyridine: An analysis of the resting rising phase of end-plate potential. Neuropharmacology 17, 439-444.
8. Katz, B., and Thesleff, S. (1957). A study of desensitization produced by acetylcholine at the motor end-plate. J. Physiol. 138, 63-80.
9. Lee, C. Y., and Chang, C. C. (1966). Modes of action of purified toxins from elapid venoms on neuromuscular transmission. Mem. Inst. Butantan 33, 555-572.
10. Lemeignan, M., Lechat, P., and Fessard, M. A. (1967). Sur l'action anticurare des aminopyridines. C. R. Acad. Sci. Paris., Série D, 264, 169-172.
11. Lundh, H. (1978). Effects of 4-aminopyridine on neuromuscular transmission. Brain Res. 153, 307-318.
12. Molgó, J., Lemeignan, M., and Lechat, P. (1977). Effects of 4-aminopyridine at the frog neuromuscular junction. J. Pharmacol. Exp. Ther. 203, 653-663.
13. Molgó, J., Lemeignan, M., and Lechat, P. (1979). Analysis of the action of 4-aminopyridine during repetitive stimulation at the neuromuscular junction. Eur. J. Pharmacol. 53, 307-311.
14. Molgó, J., Lundh, H., and Thesleff, S. (1980). Potency of 3,4-diaminopyridine and 4-aminopyridine on mammalian neuromuscular transmission and the effect of pH chances. Eur. J. Pharmacol. 61, 25-34.
15. Moussatché, H., and Melendez, T. (1979). Some pharmacological observations with Elapidae and Crotalidae snake venoms in guinea-pig denervated diaphragm. On the specificity of the cholinergic blockade by their venoms. Rev. Bras. Biol. 39, 605-610.
16. Nastuk, W. L. (1967). Activation and inactivation of the muscle postjunctional receptor. Fed. Proc. 26, 1639-1646.
17. Schauf, C. L., Colton, C. A., Cotton, J. S., and Davis, F. A. (1976). Aminopyridine and sparteine as inhibitors of membrane conductance: Effects on Myxicola giant axons and the lobster neuromuscular junction. J. Pharmacol. Exp. Ther. 197, 414-425.
18. Sobek, V., Lemeignan, M., Streichenberger, G., Benoist, J. M., Goguel, A., and Lechat, P. (1968). Étude sur le diaphragme isolé de rat de l'antagonisme entre substances curarisantes et aminopyridines. Arch. Inter. Pharmacodyn. 171, 356-368.
19. Thesleff, S. (1956a). Mode of neuromuscular block caused by acetylcholine, nicotine decamethonium and succinylcholine. Acta Physiol. Scand. 34, 218-231.
20. Thesleff, S. (1956b). The effects of acetylcholine, decamethonium and succinylcholine on neuromuscular transmission in the rat. Acta Physiol. Scand. 34, 386-392.
21. Ulbricht, W., and Wagner, H. H. (1976). Block of potassium channels of the nodal membrane by 4-aminopyridine and its partial removal by depolarization. Pflūger Arch. 367, 77-87.
22. Vital Brazil, O. (1966). Pharmacology of crystalline crotoxin II. Neuromuscular blocking action. Mem. Inst. Butantan 33, 981-992.
23. Vital Brazil, O., and Excell, B. J. (1971). Action of crotoxin and crotactin from the venom of Crotalus durissus terrificus (South American rattlesnake) on frog neuromuscular junction. J. Physiol. (London) 212, 34-135P.
24. Vital Brazil, O., Fontana, M. D., and Pavani, N. J. P. (1983). Effect of 4-aminopyridine on end-plate receptor desensitization caused by carbachol. Eur. J. Pharmacol. 86, 199-205.
25. Vital Brazil, O., Fontana, M. D., and Pavani, N. J. P. (1989). Effect of 4-aminopyridine on the postsynaptic action of polymyxin B. Eur. J. Pharmacol. 159, 47-51.
26. Weil, C. S. (1952). Tables for the convenient calculation of median effective dose (LD 50 and ED 56) and instruction in their use. Biometrics 8, 249-263.
27. Yeh, J. Z., Oxford, G. S., Wu, C. H., and Narahashi, T. (1976). Dynamics of aminopyridine block of potassium channel in squid axon membrane. J. Gen. Physiol. 68, 519-535.