IgA-λ/IgG-κ biclonal myeloma in which two clones proliferated in individual sites

Internal Medicine

Volumn 39, Issue 2, 2000, Pages 170-175

  Ando, Keiko ^a   Yaguchi, Makoto ^a   Okabe, Seiichi ^a   Miyazawa, Keisuke ^a   Ohyashiki, Kazuma ^a  

^a TOKYO MEDICAL UNIVERSITY   (Japan)

Author keywords

Biclonal; Biclonal gammopathy; Myeloma

Indexed keywords

ANTIIDIOTYPIC ANTIBODY; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; IMMUNOGLOBULIN KAPPA CHAIN; IMMUNOGLOBULIN LAMBDA CHAIN;

AGED; ARTICLE; BIOPSY; BLOOD; CASE REPORT; COMPUTER ASSISTED TOMOGRAPHY; DIFFERENTIAL DIAGNOSIS; HUMAN; IMMUNOELECTROPHORESIS; IMMUNOLOGY; INJURY; LUMBAR VERTEBRA; MALE; MULTIPLE MYELOMA; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOLOGIC FRACTURE; PATHOLOGY; RADIOGRAPHY; SPINE FRACTURE;

AGED; ANTIBODIES, ANTI-IDIOTYPIC; BIOPSY; DIAGNOSIS, DIFFERENTIAL; FRACTURES, SPONTANEOUS; HUMANS; IMMUNOELECTROPHORESIS; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; IMMUNOGLOBULIN KAPPA-CHAINS; IMMUNOGLOBULIN LAMBDA-CHAINS; LUMBAR VERTEBRAE; MAGNETIC RESONANCE IMAGING; MALE; MULTIPLE MYELOMA; SPINAL FRACTURES; TOMOGRAPHY, X-RAY COMPUTED;

EID: 0034137894     PISSN: 09182918     EISSN: None     Source Type: Journal    
DOI: 10.2169/internalmedicine.39.170     Document Type: Article

References (13)

1. Kyle RA, Robinson RA, Katzmann JA. The clinical aspects of biclonal gammopathies. Review of 57 cases. Am J Med 71: 999-1008, 1981.
2. Lolin YI, Chow J, Wickham NW. Monoclonal gammopathy of unknown significance and malignant paraproteinemia in Hong Kong. Am J Clin Pathol 106: 449-456, 1996.
3. Fernando G, Joseph C, Joel B, Bias F. A double monoclonal IgG1 κ and IgG2κ in a single myeloma patient. J Immunol 15: 551-557, 1988.
4. Obayashi H, Kanoh T, Shimazaki C, Horiike S, Nakamura M, Fukui I. Studies on 13 cases of double gammopathy. Rinsho Byori (Jpn J Clin Pathol) 39: 661-665, 1991 (in Japanese, Abstract in English).
5. Bouvet JP, Feingold J, Oriol R, Liacopoulos P. Statistical study of double paraproteinemias evidence for a common cellular origin of both myeloma globulins. Biomedicine 22: 517-523, 1975.
6. 1-λ from a single patient. Immunology 27: 1095-1101, 1974.
7. Barlogie B, Smith L, Alexanian R. Effective treatment of advanced multiple myeloma refractory to alkylating agents. N Engl. J. Med 310: 1353-1356, 1984.
8. Kyle RA.: Diagnostic criteria of multiple myeloma. Hematol Oncol Clin North Am 6: 347-358, 1992.
9. Pizzolato M, Bragantini G, Bresciani P. et al. IgG1-kappa biclonal gammopathy associated with multiple myeloma suggests a regulatory mechanism. Br J Heamatol 102: 503-508, 1998.
10. Goldrosen MH, Pruzanski W, Freedman MH. Structural and immunological studies of two IgGλ myeloma proteins from a single patient. Immunochemistry 9: 387-404, 1972.
11. Hopper JE. Comparative studies on monotypic IgMλ and IgGκ from an individual patient. Immunofluorescent evidence for a common clonal synthesis. Blood 50: 203-211, 1977.
12. Durie BG, Salmon SE. A clinical staging system for multiple myeloma. Correlation of measured myeloma cell mass with presenting clinical features, responce to treatment, and survival. Cancer 36: 824-854, 1975.
13. Goranov S. Clinical aspects of biclonal myelomas. Folia Med (Plovdiv) 36: 31-36, 1994.