Effects of pulsed electromagnetic fields on bone healing in a rabbit tibial osteotomy model

Journal of Orthopaedic Trauma

Volumn 14, Issue 2, 2000, Pages 93-100

  Fredericks, Douglas C ^a   Nepola, James V ^a   Baker, Joy T ^a   Abbott, Joan ^b   Simon, Bruce ^b  

^a UNIVERSITY OF IOWA   (United States)

^b EBI   (United States)

Author keywords

Biomechanical testing; Electromagnetic field; External fixator; Fracture repair; Rabbit tibia

Indexed keywords

ANIMAL; ARTICLE; BIOMECHANICS; ELECTROMAGNETIC FIELD; FRACTURE HEALING; MALE; OSTEOTOMY; RABBIT; TIME;

ANIMALS; BIOMECHANICS; ELECTROMAGNETIC FIELDS; FRACTURE HEALING; MALE; OSTEOTOMY; RABBITS; TIME FACTORS;

EID: 0034133504     PISSN: 08905339     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005131-200002000-00004     Document Type: Article

References (36)

1. Aaron RK, Ciombor DMcK. Acceleration of experimental endochondral ossification by biophysical stimulation of the progenitor cell pool. J Orthop Res 1996;14:582-589.
2. Aaron RK, Ciombor DMcK, Jolly G. Stimulation of experimental endochondral ossification by low-energy pulsing electromagnetic fields. J Bone Miner Res 1989;4:227-233.
3. Aaron RK, Ciombor DMcK, Jones AR. Bone induction by decalcified bone matrix and mRNA of TBFβ and IGF-1 are increased by ELF field stimulation. Presented at 43rd Annual Meeting, Orthopaedic Research Society, San Francisco, CA, 1997.
4. Auer JA. Effect of PEMF on Fracture Healing and Articular Cartilage Regeneration in Horses [Report]. College Station, TX, Texas A&M University, 1984.
5. Bassett CA. The development and application of pulsed electromagnetic fields (PEMFs) for ununited fractures and arthrodesis. Orthop Clin North Am 1984;15:61-87.
6. Bassett CAL, Pawluk RJ, Pilla AA. Acceleration of fracture repair by electromagnetic fields. A surgically noninvasive method. NY Acad Sci 1974;238:242-262.
7. Bassett CAL, Valdes MG, Hernandez E. Modification of fracture repair with selected pulsing electromagnetic fields. J Bone Joint Surg [Am] 1982;64:888-895.
8. Borsalino G, Bagnacani M, Bettati E, et al. Electrical stimulation of human femoral intertrochanteric osteotomies. Double-blind study. Clin Orthop 1988;237:256-263.
9. Brighton CT, Okereke E, Pollock SR, Clark CC. In vitro bone cell response to a capacitively coupled electrical field. The role of field strength, pulse pattern and duty cycle. Clin Orthop 1992;285: 255-262.
10. Buckwalter JA, Cruess R. Healing of musculoskeletal tissues. In: Fractures, ed by Rockwood CA, Green D. New York, Lippincott, 1991, pp 181-222.
11. Christel P, Cerf G, Pilla AA. Modulation of rat radial osteotomy repair using electromagnetic current induction. In: Mechanism of Growth Control, ed by Becker RO. Springfield, IL, CC Thomas, 1981, pp 237-250.
12. Cundy PJ, Patterson DC. A ten year review of treatment of delayed union and nonunion with an implanted bone growth stimulator. Clin Orthop 1990;259:216-222.
13. Fontanesi G, Traina GC, Giancecchi F, et al. Can delayed union in fractures be prevented? Results of electrical stimulation in fibular osteotomies in rats and in diaphyseal fractures of the tibia in humans. Ital J Orthop Traumatol Abstr 1986;12:1.
14. Goodship AE, Kenwright J. The influence of induced micromovement upon the healing of experimental tibial fractures. J Bone Joint Surg [Br] 1985;67:650-655.
15. Haimovici N. Influence of the neoformation of bone tissue by means of low-frequency pulsed magnetic fields. Biomed Thermol 1982; 107:247-255.
16. Heckman JD, Ryaby JP, McCabe J, Frey JJ, Kilcoyne RF. Acceleration of tibial fracture-healing by non-invasive, low-intensity pulsed ultrasound. J Bone Joint Surg [Am] 1994;76:26-34.
17. Hinsenkamp M, Bourgois R, Bassett CAL, Chiabrera A, Burny F, Ryaby J. Electromagnetic stimulation of fracture repair. Influence on healing of fresh fractures. Acta Orthop Belg 1978;44:671-698.
18. Kenwright J, Richardson JB, Cunningham JL, et al. Axial movement and tibial fractures. A controlled randomised trial of treatment. J Bone Joint Surg [Br] 1991;73:654-659.
19. Kenwright J, Richardson JB, Goodship AE, et al. Effect of controlled axial micromovement on healing of tibial fractures. Lancet 1986; ii:1185-1187.
20. Lavine LS, Grodzinsky AJ. Current concepts review: electrical stimulation of repair of bone. J Bone Joint Surg [Am] 1987;69: 626-630.
21. Law HT, Annan I, McCarthy ID, et al. The effect of induced electric currents on bone after experimental osteotomy in sheep. J Bone Joint Surg [Br] 1985;67:462-469.
22. Mammi GI, Rocchi R, Cadossi R, Massari L, Traina GC. The electrical stimulation of tibial osteotomies. Double-blind study. Clin Orthop 1993;288:246-253.
23. Nagai M, Ota M. Pulsating electromagnetic field stimulates mRNA expression of bone morphogenetic protein-2 and -4. J Dent Res 1994;73:1601-1605.
24. Nash TJ, Howlett CR, Martin C, Steele J, Johnson KA, Hicklin DJ. Effect of platelet-derived growth factor on tibial osteotomies in rabbits. Bone 1994;15:203-208.
25. Nepola JV, Marsh JL, Baker J. Comparison of stabilization, external fixation versus nonreamed intramedullary nail in a contaminated tibial fracture model of the rabbit: effect on infection rate and bacterial distribution. Orthop Trans 1992;16:236.
26. Pienkowsi D, Pollack SR, Brighton CT, Griffith NJ. Low-power electromagnetic stimulation of osteotomized rabbit fibulae. J Bone Joint Surg [Am] 1994;76:489-501.
27. Ryaby JT, Fitzsimmons RJ, Khin NA, et al. The role of insulin-like growth factor II in magnetic field regulation of bone formation. Bioelectrochem Bioenerg 1994;35:87-91.
28. Sahinoglu T, Bhatt B, Gullet L, et al. Pulsed electromagnetic fields induce osteogenesis and upregulate bone morphogenetic protein-2 and 4 mRNA in rat osteoblasts in vitro. Trans 42nd Annu Meeting Orthop Res Soc 1996;21:204-234.
29. Sanders-Shamis M, Bramlage LR, Weisbrode SE, Gabel AA. A preliminary investigation of the effect of selected electromagnetic field devices on healing of cannon bone osteotomies in horses. Equine Vet J 1989;21:201-205.
30. Scott G, King JB. A prospective double-blind trial of electrical capacitive coupling in the treatment of non-union of long bones. J Bone Joint Surg [Am] 1994;76:820-826.
31. Sharrard WJW. A double-blind trial of pulsed electromagnetic fields for delayed union of tibial fractures. J Bone Joint Surg [Br] 1990; 72:347-355.
32. Sharrard WJW, Sutcliffe ML, Robson MJ, Maceachern AG. The treatment of fibrous non-union of fractures by pulsing electromagnetic stimulation. J Bone Joint Surg [Br] 1982;64:189-193.
33. Wang S, Lewallen DG, Bolander ME, Chao EYS, Ilstrup DM, Greenleaf JF. Low intensity ultrasound treatment increases strength in a rat femoral fracture model. J Orthop Res 1994;12:40-47.
34. White AA, Panjabi MM, Southwick WA. The four biomechanical stages of fracture repair. J Bone Joint Surg [Am] 1977;59:188-192.
35. Wolf JW Jr, White AA III, Panjabi MM, Southwick WO. Comparison of cyclic loading versus constant compression in the treatment of long-bone fractures in rabbits. J Bone Joint Surg [Am] 1981;63: 805-810.
36. Yen-Patton GPA, Patton WF, Beer DM, Jacobson BS. Endothelial cell response to pulsed electromagnetic fields: stimulation of growth rate and angiogenesis in vitro. J Cell Physiol 1988;134:37-46.