Experimental Evaluation of a Model for Oxygen Exchange in a Pulsating Intravascular Artificial Lung

Annals of Biomedical Engineering

Volumn 28, Issue 2, 2000, Pages 160-167

  Federspiel, William J ^a,b,c   Hewitt, Todd J ^b   Hattler, Brack G ^a  

^a UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^b PA 15260   (United States)

^c UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

Artificial lung; Gas exchange; Gas transfer; Hollow fibers; IMO; Intravenous oxygenation; Respiratory support

Indexed keywords

OXYGEN;

ARTICLE; ARTIFICIAL VENTILATION; BIOLOGICAL MODEL; HUMAN; LUNG GAS EXCHANGE; METABOLISM; METHODOLOGY; NONLINEAR SYSTEM; PHYSIOLOGY; PREDICTION AND FORECASTING; REGRESSION ANALYSIS;

HUMANS; MODELS, BIOLOGICAL; NONLINEAR DYNAMICS; OXYGEN; PREDICTIVE VALUE OF TESTS; PULMONARY GAS EXCHANGE; REGRESSION ANALYSIS; RESPIRATION, ARTIFICIAL;

EID: 0034133076     PISSN: 00906964     EISSN: None     Source Type: Journal    
DOI: 10.1114/1.240     Document Type: Article

References (15)

1. Conrad, S. A. et al. Major findings from the clinical trials of the intravascular oxygenator. Artif. Organs 18:846-863, 1994.
2. Federspiel, W. J., T. J. Hewitt, M. S. Hout, F. R. Walters, L. W. Lund, P. Sawzik, G. D. Reeder, H. S. Borovetz, and B. G. Hattler. Recent progress in engineering the Pittsburgh Intravenous Membrane Oxygenator. ASAIO J. 42:M435-M442, 1996.
3. Federspiel, W. J., P. Sawzik, H. Borovetz, G. D. Reeder, and B. G. Hattler. Temporary support of the lungs - The artificial lung, edited by D. K. C. Cooper, L. W. Miller, G. A. Patterson. The Transplantation and Replacement of Thoracic Organs, Boston: Kluwer Academic, 1996, p. 824.
4. Federspiel, W. J., M. S. Hout, T. J. Hewitt, L. W. Lund, S. A. Heinrich, P. Litwak, F. R. Walters, G. D. Reeder, H. S. Borovetz, and B. G. Hattler. Development of a low flow resistance intravenous oxygenator. ASAIO J. 43:M725-M730, 1997.
5. Hattler, B. G., G. D. Reeder, P. J. Sawzik, L. W. Lund, F. R. Walters, A. S. Shah, J. Rawleigh, J. S. Goode, M. Klain, and H. S. Borovetz. Development of an intravenous membrane oxygenator: enhanced intravenous gas exchange through convective mixing of blood around hollow fiber membranes. Artif. Organs 18:806-812, 1994.
6. Hewitt, T. J., B. G. Hattler, and W. J. Federspiel. A mathematical model of gas exchange in an intravenous membrane oxygenator. Ann. Biomed. Eng. 26(1):166-178, 1998.
7. High, K. M., M. T. Snider, R. Richard, G. B. Russell, J. K. Stene, D. B. Campbell, T. X. Aufiero, and G. A. Thieme. Clinical trials of an intravenous oxygenator in patients with adult respiratory distress syndrome. Anesthesiology 77:856-863, 1992.
8. Makarewicz, A. J., and L. F. Mockros. Modeling oxygen transfer to blood from crossflow membrane oxygenators. ASME: Bioengineering Division 29:467-468, 1995.
9. Mortensen, J. D. Intravascular oxygenator: A new alternative method for augmenting blood gas transfer in patients with acute respiratory failure. Artif. Organs 16:75-82, 1992.
10. Niranjan, S. C., J. W. Clark, K. Y. San, J. B. Zwischenberger, and A. Bidani. Analysis of factors affecting gas exchange in intravascular blood gas exchanger. J. Appl. Physiol. 77:1716-1730, 1994.
11. 2 transfer through microporous hollow fibers by pressure cycling. Ann. Biomed. Eng. 26:1044-1054, 1998.
12. Tao, W., and J. B. Zwishenberger. Intracorporeal gas exchange: Taking further steps. ASAIO J. 44(3):224-226, 1998.
13. Vaslef, S. N., L. F. Mockros, K. E. Cook, R. J. Leonard, J. C. Sung, and R. W. Anderson. Computer-assisted design of an implantable, intrathoracic artificial lung. Artif. Organs 18(11):813-817, 1994.
14. Vaslef, S. N., L. F. Mockros, R. W. Anderson, and R. J. Leonard. Use of a mathematical model to predict oxygen transfer rates in hollow fiber membrane oxygenators. ASAIO J. 40:990-996, 1994.
15. Wickramasinghe, S. R., M. J. Semmens, and E. L. Cussler. Hollow fiber modules made with hollow fiber fabric. J. Membr. Sci. 84:1-14, 1993.