Anthraquinone-oligodeoxynucleotide conjugates as inhibitors of gene transcription

Journal of Pharmacy and Pharmacology

Volumn 52, Issue 6, 2000, Pages 599-602

  Gibson, V ^b   Anderson, R J ^b   Hartley, J A ^a   McAdam, S R ^a   Cairns, D ^b  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF SUNDERLAND   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTHRAQUINONE OLIGODEOXYNUCLEOTIDE CONJUGATE; BETA LACTAMASE; OLIGODEOXYNUCLEOTIDE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL GENE; CONTROLLED STUDY; DRUG SYNTHESIS; ESCHERICHIA COLI; GENETIC TRANSCRIPTION; MESSENGER RNA SYNTHESIS; NONHUMAN;

ESCHERICHIA COLI;

EID: 0034131380     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/0022357001774426     Document Type: Article

References (12)

1. Collier, D. A., Thuong, N. T., Hélène, C. (1991) Sequence-specific bifunctional DNA ligands based on triple-helix-forming oligonucleotides inhibit restriction enzyme cleavage under physiological conditions. J. Am. Chem. Soc. 113: 1457-1458
2. Duval-Valentin, G., Thuong, N. T., Hélène, C. (1992) Specific inhibition of transcription by triple-helix-forming oligo-nucleotides. Proc. Natl Acad. Sci. USA 89: 504-508
3. Gibson, V., Anderson, R. J., Brown, J. R., Hartley, S. A., Cassidy, S. A., Fox, K. R., Cairns, D. (1996a) Anthraquinone-oligodeoxynucleotide conjugates as triple helix-stabilizing agents. Pharm. Sci. 2: 49-53
4. Gibson, V., Anderson, R. J., Brown, J. R., Mackay, S. P., Cairns, D. (1996b) Molecular modelling of anthraquinone-oligodeoxynucleotide conjugates. Pharm. Sci. 2: 545-548
5. Gibson, V., Anderson, R. J., Cairns, D., Mackay, S. P. (1997) Molecular modelling of anthraquinone-oligodeoxynucleotide conjugates containing protonated cytosines. Pharm. Sci. 3: 569-572
6. Hartley, J. A., Wyatt, M. D. (1997) Determination of the sequence specificity of alkylation damage using cleavage-based assays. In: Methods in Molecular Biology, Vol. 90: Drug-DNA Interaction Protocols, Fox, K. (ed.) Humana Press, Totowa, NJ, pp 147-156
7. Hélène, C. (1991) The anti-gene strategy: control of gene expression by triplex-forming oligonucleotides. Anti-Cancer Drug Design 6: 569-584
8. Hélène, C., Toulme, J. J. (1990) Specific regulation of gene expression by antisense, sense and antigene nucleic acids. Biochem. Biophys. Acta 1049: 99-125
9. Hoogsteen, K. (1959) The structure of crystals containing a hydrogen-bonded complex of 1-methylthymine and 9-methyladenine. Acta Crystallogr. 12: 822-823
10. Islam, S. A., Neidle, S., Gandecha, B. M., Patterson, L. H., Brown, J. R. (1985) Comparative computer graphics and solution studies of the DNA interaction of substituted anthraquinones based on doxorubicin and mitoxantrone. J. Med. Chem. 28: 857-864
11. Lee, J. S., Woodworth, M. L., Latimer, L. J. P., Morgan, A. R. (1984) Poly(pyrimidine) poly(purine) synthetic DNAs containing 5-methylcytosine form stable triplexes at neutral pH. Nucleic Acid Res. 12: 6603-6614
12. Sun, J. S., Francois, J. C., Montenay-Garestier, T., Saison-Behmoaras, T., Roig, V., Thuong, N. T., Hélène, C. (1989) Sequence-specific intercalating agents: intercalation at specific sequences on duplex DNA via major groove recognition by oligonucleotide-intercalator conjugates. Proc. Natl Acad. Sci. USA 86: 9198-9202