Identification of somatotrophs, mammosomatotrophs, and mammotrophs by sandwich cell immunoblot assay in GH-secreting adenomas and prolactinomas: Correlations between the proportions of hormone secreting cells and tumor size

Endocrine Journal

Volumn 47, Issue 2, 2000, Pages 143-155

  Kojima, Yasuhiro ^a   Suzuki, Shinichi ^a   Yamamura, Koji ^a   Kawasaki, Takashi ^a   Yamamoto, Isao ^a  

^a YOKOHAMA CITY UNIVERSITY   (Japan)

Author keywords

GH secreting adenoma; Pituitary adenoma; Prolactinoma; Sandwich cell immunoblot assay

Indexed keywords

ADENOMA; ADOLESCENT; ADULT; ARTICLE; CELL ISOLATION; CLINICAL ARTICLE; DIAGNOSTIC VALUE; FEMALE; GROWTH HORMONE BLOOD LEVEL; GROWTH HORMONE RELEASE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; PROLACTINOMA;

EID: 0034130487     PISSN: 09188959     EISSN: None     Source Type: Journal    
DOI: 10.1507/endocrj.47.143     Document Type: Article

References (38)

1. Bassetti M, Spada A, Arosio M, Vallar L, Brina M, Giannattasio G (1986) Morphological studies on mixed growth hormone (GH)- and prolactin (PRL)-secreting human pituitary adenomas. Coexistence of GH and PRL in the same secretory granule. J Clin Endocrinol Metab 62: 1093-1100.
2. Goluboff IG, Ezrin C (1969) Effect of pregnancy on the somatotroph and the prolactin cell of the human adenohypophysis. J Clin Endocrinol Metab 29: 1535-1538.
3. Horvath E, Kovacs K, Killinger DW, Smyth H, Weiss MH, Ezrin C (1983) Mammosomatotroph cell adenoma of the human pituitary: A morphologic entity. Virchows Arch A Pathol Anat Histopathol 398: 277-289.
4. Corenblum B, Ssiek AMT, Horvath E, Kovacs K, Ezrin C (1976) Human mixed somatotrophic and lactotrophic pituitary adenomas. J Clin Endocrinol Metab 42: 857-863.
5. Farquhar MG, Dellman HD, Johnson JA, Klachko DM (1977) Secretion and crinophagy in prolactin cells. In: Comparative Endocrinology of Prolactin. Plenum Press, New York, pp. 37-94.
6. Guyda H, Robert F, Colle E, Hardy J (1973) Histologic, ultrastructural and hormonal characterization of a pituitary tumor secreting both hGH and prolactin. J Clin Endocrinol Metab 36: 531-547.
7. Martin JB (1973) Neural regulation of growth hormone secretion. N Engl J Med 288: 1384-1393.
8. Mashiter K, Adams E, Beard M, Holley A (1977) Bromocriptine inhibits prolactin and growth hormone release by human pituitary tumors in culture. Lancet 2: 197-198.
9. Zurschmiede C, Landolt AM (1987) Distribution of growth hormone and prolactin human adenohypophysis. Virchows Arch B Cell Pathol Incl Mol Pathol 53: 308-315.
10. Felix IA, Horvath E, Kovacs K, Smyth HS, Killinger DW, Vale J (1986) Mammosomatotroph adenoma of the pituitary associated with gigantism and hyperprolactinemia: A morphological study including immunoelectron microscopy. Acta Neuropathol (Berl) 71: 76-82.
11. Halmi NS (1982) Occurrence of both growth hormone- and prolactin-immunoreactive material in the cells of human somatotrophic pituitary adenomas containing mammotrophic elements. Virchows Arch A Pathol Anat Histopathol 398: 19-31.
12. Heitz PU, Landolt AM, Zenklusen HR, Kasper M, Reubi JC, Oberholzer M, Roth J (1987) Immunocytochemistry of pituitary tumors. J Histochem Cytochem 35: 1005-1011.
13. Ishibashi T, Shiino M (1989) Co-localization pattern of growth hormone (GH) and prolactin (PRL) within the anterior pituitary cells in the female rat and female musk shrew. Anat Rec 223: 185-193.
14. Ishikawa H, Nogami H, Kamio M, Suzuki T (1983) Single secretory granules contain both GH and prolactin in pituitary mixed type adenoma. Virchows Arch A Pathol Anat Histopathol 399: 221-226.
15. Kameya T, Tsumuraya M, Adachi I, Abe K, Ichikizaki K, Toya S, Demura R (1980) Ultrastructure, immunohistochemistry and hormone release of pituitary adenomas in relation to prolactin production. Virchows Arch [Pathol Anat] 387: 31-46.
16. Kanie N, Kageyama N, Kuwayama A, Nakane T, Watanabe M, Kawaoi A (1983) Pituitary adenomas in acromegalic patients: An immunohistochemical and endocrinological study with special reference to prolactin-secreting adenoma. J Clin Endocrinol Metab 57: 1093-1101.
17. Landolt AM, Heitz PHU (1986) Alpha-subunit-producing pituitary adenomas: Immunocytochemical and ultrastructural studies. Virchows Arch A Pathol Anat Histopathol 409: 417-431.
18. Landolt AM, Rothenbuhler V (1978) Extracellular growth hormone deposits in pituitary adenoma. Virchows Arch A Pathol Pathol Anat 378: 55-65.
19. Lloyd RV, Anagnostou D, Cano M, Barken AL, Chandler WF (1988) Analysis of mammosomatotropic cells in normal and neoplastic human pituitary tissues by the reverse hemolytic plaque assay and immunocytochemistry. J Clin Endocrinol Metab 66: 1103-1110.
20. Nakane PK (1968) Simultaneous localization of multiple tissue antigens using the peroxidase-labeled antibody method: a study on pituitary glands of the rat. J Histochem Cytochem 16: 557-560.
21. Nikitovich-Winer BM, Atkin J, Maley BE (1987) Colocalization of prolactin and growth hormone within specific adenohypophyseal cells in male, female and lactating female. Endocrinology 121: 625-630.
22. Teramoto A (1980) Immunocytochemical studies on the functioning pituitary adenomas. No to Shinkei 32: 1163-1174 (In Japanese).
23. Trouillas J, Girod C, Lheritier M, Claustrat B, Dubois MD (1980) Morphological and biochemical relationships in 31 human pituitary adenomas with acromegaly. Virchows Arch [Pathol Anat] 389: 127-142.
24. Leong DA, Lau SK, Sinha YN, Kasiser DL, Thorner MO (1985) Enumeration of lactotropes and somatotropes among male and female pituitary cells in culture: evidence in favor of a mammosomatotrope subpopulation in the rat. Endocrinology 116: 1371-1378.
25. Nakane PK (1970) Classifications of anterior pituitary cell types with immunoenzyme histochemistry. J Histochem Cytochem 18: 9-20.
26. Kendall ME, Hymer WC (1987) Cell blotting: a new approach to quantify hormone secretion from individual rat pituitary cells. Endocrinology 121: 2260-2262.
27. Arita J (1993) Analysis of the secretion from single anterior pituitary cells by cell immunoblot assay. Endocr J 40: 1-15.
28. Arita J, Kojima Y, Yamamoto I, Kimura F (1994) Somatotropes and thyrotropes in the rat anterior pituitary gland cosecrete substance P: Analysis by the sandwich cell immunoblot assay. Neuroendocrinology 60: 567-574.
29. Arita J, Kojima Y, Kimura F (1991) Identification by the sequential cell immunoblot assay of a subpopulation of rat dopamine-unresponsive lactotrophs. Endocrinology 128: 1887-1894.
30. Arita J, Kojima Y, Kimura F (1992) Lactotrophs secreting small amounts of prolactin reveal great responsiveness to thyrotropin-releasing hormone: Analysis by the sequential cell immunoblot assay. Endocrinology 130: 3167-3174.
31. Kojima Y, Arita J, Kuwana N (1995) Mammosomatotroph adenoma cells secrete both growth hormone and prolactin. Neurol Med Chir (Tokyo) 35: 791-796.
32. Bassetti M, Arosio M, Spada A, Brina M, Bazzoni N, Faglia G, Giannattasio G (1988) Growth hormone and prolactin secretion in acromegaly: Correlations between hormonal dynamics and immunocytochemical findings. J Clin Endocrinol Metab 67: 1195-1204.
33. Kineman RD, Faught WJ, Frawley LS (1991) Mammosomatotropes are abundant in bovine pituitaries: influence of gonadal status. Endocrinology 128: 2229-2233.
34. Frawley LS, Bookfor FR (1991) Mammosomatotropes: presence and functions in normal and neoplastic pituitary tissue. Endocr Rev 12: 337-355.
35. Bookfor FR, Hoeffler JP, Frawley LS (1986) Analysis by plaque assays of GH and prolactin release from individual cells in cultures of male pituitaries. Neuroendocrinology 42: 64-70.
36. Kojima Y, Arita J, Kuwana N, Kimura F (1995) Dopamine responsiveness of human prolactinoma cells as determined by the reverse hemolytic plaque assay. Endocr J 42: 355-360.
37. Melmed S, Braunstein GD, Horvath E, Ezrin C, Kovacs K (1983) Pathophysiology of acromegaly. Endocr Rev 4: 271-290.
38. Porter TE, Wiles CD, Frawley LS (1991) Evidence for bidirectional interconversion of mammotropes and somatotropes: Rapid reversion of acidophilic cell types to pregestational proportions after weaning. Endocrinology 129: 1215-1220.