Molecular analysis of Irish sheep scrapie cases

Journal of General Virology

Volumn 81, Issue 6, 2000, Pages 1621-1627

  Sweeney, Torres ^c   Kuczius, Thorsten ^a   McElroy, Marie ^b   Gomerez Parada, Mercedes ^b   Groschup, Martin H ^b  

^a FEDERAL RESEARCH INSTITUTE FOR ANIMAL HEALTH   (Germany)

^b VETERINARY LABORATORIES AGENCY   (United Kingdom)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

MONOCLONAL ANTIBODY; PRION PROTEIN; PROTEINASE K;

ANIMAL TISSUE; ARTICLE; BASAL GANGLION; BOVINE SPONGIFORM ENCEPHALOPATHY; BRAIN CORTEX; BRAIN HOMOGENATE; CONTROLLED STUDY; HYPOTHALAMUS; IRELAND; MEDULLA OBLONGATA; METHODOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN GLYCOSYLATION; SCRAPIE; SHEEP DISEASE; THALAMUS; THORACIC SPINAL CORD;

ANIMALIA; BOS TAURUS; BOVINAE; OVIS; OVIS ARIES; RODENTIA;

EID: 0034129034     PISSN: 00221317     EISSN: None     Source Type: Journal    
DOI: 10.1099/0022-1317-81-6-1621     Document Type: Article

References (33)

1. Baron, T. G., Madec, J. Y. & Calavas, D. (1999). Similar signature of the prion protein in natural sheep scrapie and bovine spongiform encephalopathy-linked diseases. Journal of Clinical Microbiology 37, 3701-3704.
2. Bessen, R. A. & Marsh, R. F. (1992). Biochemical and physical properties of the prion protein from two strains of the transmissible mink encephalopathy agent. Journal of Virology 66, 2096-2101.
3. Bessen, R. A. & Marsh, R. F. (1994). Distinct PrP properties suggest the molecular basis of strain variation in transmissible mink encephalopathy. Journal of Virology 68, 7859-7868.
4. Bruce, M. E. & Dickinson, A. G. (1987). Biological evidence that scrapie agent has an independent genome. Journal of General Virology 68, 79-89.
5. Bruce, M. E., McConnell, I., Fraser, H. & Dickinson, A. G. (1991). The disease characteristics of different strains of scrapie in Sinc congenic mouse lines: implications for the nature of the agent and host control of pathogenesis. Journal of General Virology 72, 595-603.
6. Bruce, M. E., Will, R. G., Ironside, J. W., McConnell, I., Drummond, D., Suttie, A., McCardle, L., Chree, A., Hope, J., Birkett, C., Cousens, S., Fraser, H. & Bostock, C. J. (1997). Transmissions to mice indicate that 'new variant' CJD is caused by the BSE agent. Nature 389, 498-501.
7. Collinge, J., Sidle, K. C., Meads, J., Ironside, J. & Hill, A. F. (1996). Molecular analysis of prion strain variation and the aetiology of 'new variant' CJD. Nature 383, 685-690.
8. Dickinson, A. G. & Meikle, V. M. H. (1971). Host-genotype and agent effects in scrapie incubation: change in allelic interaction with different strains of agent. Molecular and General Genetics 112, 73-79.
9. Diringer, H., Hilmert, H., Simon, D., Werner, E. & Ehlers, B. (1983). Towards purification of the scrapie agent. European Journal of Biochemistry 134, 555-560.
10. Foster, J. D., Hope, J. & Fraser, H. (1993). Transmission of bovine spongiform encephalopathy to sheep and goats. Veterinary Record 133, 339-341.
11. Fraser, H. & Dickinson, A. G. (1973). Scrapie in mice. Agent-strain differences in the distribution and intensity of grey matter vacuolation. Journal of Comparative Pathology 83, 29-40.
12. Groschup, M. H. & Pfaff, E. (1993). Studies on a species-specific epitope in murine, ovine and bovine prion protein. Journal of General Virology 74, 1451-1456.
13. Harmeyer, S., Pfaff, E. & Groschup, M. H. (1998). Synthetic peptide vaccines yield monoclonal antibodies to cellular and pathological prion proteins of ruminants. Journal of General Virology 79, 937-945.
14. Hill, A. F., Desbruslais, M., Joiner, S., Sidle, K. C., Gowland, I., Collinge, J., Doey, L. J. & Lantos, P. (1997). The same prion strain causes vCJD and BSE. Nature 389, 448-450.
15. Hill, A. F., Sidle, K. C. L., Joiner, S., Keyes, P., Martin, T. C., Dawson, M. & Collinge, J. (1998). Molecular screening of sheep for bovine spongiform encephalopathy. Neuroscience Letters 255, 159-162.
16. Hope, J., Wood, S. C. E. R., Birkett, C. R., Chong, A., Bruce, M. E., Cairns, D., Goldmann, W., Hunter, N. & Bostock, C. J. (1999). Molecular analysis of ovine prion protein identifies similarities between BSE and an experimental isolate of natural scrapie, CH1641. Journal of General Virology 80, 1-4.
17. Kascsak, R. J., Rubenstein, R., Merz, P. A., Carp, R. I., Wisniewski, H. M. & Diringer, H. (1985). Biochemical differences among scrapie-associated fibrils support the biological diversity of scrapie agents Journal of General Virology 66, 1715-1722.
18. Kimberlin, R. H. & Walker, C. A. (1978). Evidence that the transmission of one source of scrapie agent to hamsters involves separation of agent strains from a mixture. Journal of General Virology 39, 487-496.
19. Kimberlin, R. H., Walker, C. A. & Fraser, H. (1989). The genomic identity of different strains of mouse scrapie is expressed in hamsters and preserved on reisolation in mice. Journal of General Virology 70, 2017-2025.
20. Kuczius, T. & Groschup, M. H. (1999). Differences in proteinase K resistance and neuronal deposition of abnormal prion proteins characterize bovine spongiform encephalopathy (BSE) and scrapie strains. Molecular Medicine 5, 406-418.
21. Kuczius, T., Haist, I. & Groschup, M. H. (1998). Molecular analysis of bovine spongiform encephalopathy and scrapie strain variation. Journal of Infectious Diseases 178, 693-699.
22. McElroy, M., Weavers, E., Gomerez Parada, M., Healy, A., Doherty, M., Sweeney, T., O'Doherty, E., Aherne, M., Church, A., Monks, E., Roche, J. F. & Collins, D. J. (2000). Establishment of a tissue bank and database of naturally occurring scrapie in sheep in Ireland. Irish Veterinary Journal (in press).
23. Oesch, B., Westaway, D., Walchli, M., McKinley, M. P., Kent, S. B., Aebersold, R., Barry, R. A., Tempst, P., Teplow, D. B., Hood, L. E. and others (1985). A cellular gene encodes scrapie PrP 27-30 protein. Cell 40, 735-746.
24. Pan, K. M., Baldwin, M., Nguyen, J., Gasset, M., Serban, A., Groth, D., Mehlhorn, I., Huang, Z., Fletterick, R. J., Cohen, F. E. & Prusiner, S. B. (1993). Conversion of alpha-helices into beta-sheets features in the formation of the scrapie prion proteins. Proceedings of the National Academy of Sciences. USA 90, 10962-10966.
25. Parchi, P., Capellari, S., Chen, S. G., Petersen, R. B., Gambetti, P., Kopp, N., Brown, P., Kitamoto, T., Tateishi, J., Giese, A. & Kretzschmar, H. (1997). Typing priori isoforms. Nature 386, 232-234.
26. Pergami, P., Jaffe, H. & Safar, J. (1996). Semipreparative Chromatographic method to purify the normal cellular isoform of the prion protein in nondenatured form. Analytical Biochemistry 236, 63-73.
27. Prusiner, S. B. & DeArmond, S. J. (1994). Prion diseases and neuro-degeneration. Annual Review of Neuroscience 17, 311-339.
28. Riek, R., Hornemann, S., Wider, G., Billeter, M., Glockshuber, R. & Wuthrich, K. (1996). NMR structure of the mouse prion protein domain PrP(121-321). Nature 382, 180-182.
29. Safar, J., Roller, P. P., Gajdusek, D. C. & Gibbs, C. J., Jr (1993). Conformational transitions, dissociation, and unfolding of scrapie amyloid (prion) protein. Journal of Biological Chemistry 268, 20276-20284.
30. Safar, J., Wille, H., Itri, V., Groth, D., Serban, H., Torchia, M., Cohen, F. E. & Prusiner, S. B. (1998). Eight prion strains have PrP(Sc) molecules with different conformations. Nature Medicine 4, 1157-1165.
31. Somerville, R. A. (1999). Host and transmissible spongiform encephalopathy agent strain control glycosylation of PrP. Journal of General Virology 80, 1865-1872.
32. Somerville, R. A., Chong, A., Mulqueen, O. U., Birkett, C. R., Wood, S. C. & Hope, J. (1997). Biochemical typing of scrapie strains. Nature 386, 564.
33. Wadsworth, J. D. F., Hill, A. F., Joiner, S., Jackson, G. S., Clarke, A. R. & Collinge, J. (1999). Strain specific prion conformation determined by metal ions. Nature Cell Biology 1, 55-59.