Detection of hepatitis B virus polymerase variations resistant to lamivudine therapy

Chinese Medical Journal

Volumn 113, Issue 5, 2000, Pages 455-457

  Zhang, Xinxin ^a   Han, Yongnian ^a   Lu, Zhimeng ^a   Zhang, Donghua ^a   Cai, Yimei ^a  

^a SHANGHAI SECOND MEDICAL UNIVERSITY   (China)

Author keywords

Hepatitis B virus; Lamivudine; Polymerase; Variation

Indexed keywords

LAMIVUDINE; VIRUS DNA;

ARTICLE; CONTROLLED STUDY; HEPATITIS B; HEPATITIS B VIRUS; HUMAN; MAJOR CLINICAL STUDY; NONHUMAN; POLYMERASE CHAIN REACTION; TREATMENT FAILURE; VIRUS GENE; VIRUS ISOLATION; VIRUS MUTATION;

ANTIVIRAL AGENTS; DRUG RESISTANCE, MICROBIAL; GENE PRODUCTS, POL; HEPATITIS B VIRUS; HEPATITIS B, CHRONIC; HUMANS; LAMIVUDINE; POLYMERASE CHAIN REACTION;

EID: 0034128471     PISSN: 03666999     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (10)

1. Doong SL, Tsai CH, Schinaizi RF, et al. Inhibition of the replication of hepatitis B virus in vitro by 2 ′ , 3 ′-dideoxy-3 ′-thiacytidine and related analogues. Proc Natl Acad Sci U S A 1991;88: 8495-8499.
2. Bartholomew MM, Jansen RW, Jeffers LJ, et al. Hepatitis B virus resistance to lamivudine given for recurrent infection after orthotopic liver transplantation. Lancet 1997;349:20-22.
3. Tipples GA, Ma MM, Ficher KP, et al. Mutation in HBV RNA-dependent DNA polymerase confers resistance to lamivudine in vivo. Hepatology 1996;24:714-717.
4. Honkoop P, Niesters H, De Man R, et al. Lamivudine resistance in immunocompetent chronic hepatitis B. J Hepatol 1997;26: 1393-1395.
5. Poch O, Sauvaget I, Delarue M, et al. Identification of four conserved motifs among the RNA-dependent polymerase encoding elements. EMBO J 1989;8:3867-3874.
6. Tyrrell D, Mitchell MC, De Man R, et al. Phase II trial of lamivudine for chronic hepatitis B (abstract) . Hepatology 1993; 18: 112A.
7. Dienstag JL, Perillo RP, Schiff ER, et al. A preliminary trial of lamivudine for chronic viral hepatitis B infection. N Engl J Med 1995;333:1657-1661.
8. Tisdal M, Kemp SD, Parry NR, et al. Rapid in vitro selection of human immunodeficiency virus type 1 resistant to 3 ′ -thiacytidine inhibitors due to a mutant in the YMDD region of reverse transcriptase. Proc Natl Acad Sci U S A 1993;90:5653-5656.
9. Wainberg MA, Salomon H, Gu Z, et al. Development of HIV-1 resistance to (-) 2 ′-deoxy-3 ′-thiacytidine in patients with AIDS or advanced AIDS-related complex. AIDS 1995;9:351-357.
10. Fischer KP, Tyrrell DLJ. Generation of duck hepatitis B virus polymerase mutants through site-directed mutagenesis which demonstrate resistance to lamivudine in vitro. Antimicrob Agents Chemother 1996; 40:1957-1960.