Neutrophil depletion in rats reduces burn-injury induced intestinal bacterial translocation

Critical Care Medicine

Volumn 28, Issue 5, 2000, Pages 1550-1555

  Fazal, Nadeem ^a   Shamim, Muhammad ^a   Khan, Shafeeq S ^a   Gamelli, Richard L ^a   Sayeed, Mohammed M ^a,b  

^a LOYOLA UNIVERSITY CHICAGO   (United States)

^b LOYOLA UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Escherichia coli; Intestinal dysfunction; Mesenteric lymph nodes; Microvascular injury; Mucosal barrier; Myeloperoxidase; Polymerase chain reaction; Southern blot; Tissue injury; galactosidase

Indexed keywords

BETA GALACTOSIDASE; GRANULOCYTE ANTIBODY; MYELOPEROXIDASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SUPEROXIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL TRANSLOCATION; BURN; ENZYME ACTIVITY; ENZYME LOCALIZATION; ESCHERICHIA COLI; IMMUNOHISTOCHEMISTRY; NEUTROPENIA; NEUTROPHIL; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROSPECTIVE STUDY; RAT; SOUTHERN BLOTTING; TISSUE INJURY;

EID: 0034127153     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/00003246-200005000-00048     Document Type: Article

References (37)

1. 1. Wolochow H, Hildebrand GJ, LaManna C: Translocation of microorganisms across the intestinal wall of the rat: Effect of microbial size and concentration. J Infect Dis 1966; 116:523
2. 2. Berg RD, Garlington AW: Translocation of certain indigenous bacteria from the gastrointestinal tract to the mesenteric lymph nodes and other organs in a gnotobiotic mouse model. Infect Immun 1979; 23: 403-411
3. 3. Carrico CJ, Meakins JL, Marshall JC, Fry D, Maier RV: Multiple-organ-failure syndrome. Arch Surg 1986; 121:196-208
4. 4. Offenbartl K, Bengmark S: Intraabdominal infections and gut origin sepsis. World J Surg 1990; 14:191-195
5. 5. Deitch EA, Winterton J, Berg R: Thermal injury promotes bacterial translocation from the gastrointestinal tract in mice with impaired T-cell-mediated immunity. Arch Surg 1986; 121:97-101
6. 6. Maejima K, Deitch E, Berg R: Promotion by burn stress of the translocation of bacteria from the gastrointestinal tracts of mice. Arch Surg 1984; 119:166-172
7. 7. Baker CC: Hemorrhagic shock and interleukin-2 production. Crit Care Med 1988; 16: 358-359
8. 8. Deitch EA, Taylor M, Grisham M, Ma L, Bridges W, Berg R: Endotoxin induces bacterial translocation and increases xanthine oxidase activity. J Trauma 1989; 29: 1679-1683
9. 9. Berg RD: Promotion of the translocation of enteric bacteria from the gastrointestinal tracts of mice by oral treatment with penicillin, clindamycin, or metronidazole. Infect Immun 1981; 33:854-861
10. 10. Penn RL, Maca RD, Berg RD: Increased translocation of bacteria from the gastrointestinal tracts of tumor-bearing mice. Infect Immun 1985; 47:793-798
11. 11. Berg RD: Bacterial translocation form the gastrointestinal tract. J Med 1992; 23: 217-244
12. 12. Deitch EA, Bridges WM, Ma JW, et al: Obstructed intestine as a reservoir for systemic infection. Am J Surg 1990; 159:394-401
13. 13. Deitch EA, Sittig K, Li M, et al: Obstructive jaundice promotes bacterial translocation from the gut. Am J Surg 1990; 159:79-84
14. 14. Deitch EA, Berg RD: Endotoxin but not malnutrition promotes bacterial translocation of the gut flora in burned mice. J Trauma 1987; 27:161-166
15. 15. Spaeth G, Specian RD, Berg RD, et al: Bulk prevents bacterial translocation induced by the oral administration of total parenteral nutrition solution. JPEN J Parenter Enteral Nutr 1990; 14:442-447
16. 16. Weiss SJ: Tissue destruction by neutrophils. N Engl J Med 1989; 320:365-376
17. 17. Demling RH, Lalonde C: Early postburn lipid peroxidation: Effect of ibuprofen and allopurinol. Surgery 1990; 107:85-93
18. 18. Till GO, Beauchamp C, Menapace D: Oxygen radical dependent lung damage following thermal injury of rat skin. J Trauma 1983; 1983:23:269-277
19. 19. Till GO, Hatherill JR, Tourtellote WW: Lipid peroxidation and acute lung injury after thermal trauma to skin: Evidence of a role for hydroxyl radical. Am J Pathol 1985; 119: 376-384
20. 20. Simms HH: Polymorphonuclear leukocytes: Their role as central cellular elements in shock pathogenesis. Shock 1995; 2:225-231
21. 21. Fazal N, Sabeh F, Gamelli RL, et al: Elevated expression of p47phox and p67phox proteins in neutrophils from burned rats. Shock 1997; 8:256-260
22. 22. Suzuki K, Ota H, Sasagawa S, et al: Assay method for the myeloperoxidase in human polymorphonuclear leukocytes. Anal Biochem 1983; 132:345
23. 23. Kane TD, Johnson, SR, Alexander JW, et al: Detection of intestinal bacterial translocation using PCR. J Surg Res 1996; 63:59-63
24. 24. Clark RA: The human neutrophil respiratory burst oxidase. J Infect Dis 1990; 161: 1140-1147
25. 25. Cetinkale O, Konukoglu D, Senel O, et al: Modulating the functions of neutrophils and lipid peroxidation by FK506 in a rat model of thermal injury. Burns 1999; 25:105-112
26. 26. Cetinkale O, Senel O, Bulan R: The effect of antioxidant therapy on cell-mediated immunity following burn injury in an animal model. Burns 1999; 25:113-118
27. 2- generation after burn injury. Am J Physiol 1998; 274:R476-R485
28. 28. Horton JW, White J, Maass D, et al: Arginine in burn injury improves cardiac performance and prevents bacterial translocation. J Appl Physiol 1998; 84:695-702
29. 29. Deitch E, Bridges W, Ma L, et al: Hemorrhagic shock-induced bacterial translocation: The role of neutrophils and hydroxyl radicals. J Trauma 1990; 30:942-952
30. 30. Till GO, Johnson KJ, Kunkel R, et al: Intravascular activation of complement and acute lung injury. Dependency on neutrophils and toxic oxygen metabolites. J Clin Invest 1982; 69:1126-1135
31. 31. Jolly SR, Kane WJ, Hook BG, et al: Reduction of myocardial infarct size by neutrophil depletion: Effect of duration of occlusion. Am Heart J 1986; 112:682-690
32. 32. Yamada T, Grisham MB: Role of neutrophil-derived oxidants in the pathogenesis of intestinal inflammation. Klin Wochenschr 1991; 69:988-994
33. 33. Smith SM, Holm-Rutili L, Perry MA, et al: Role of neutrophils in hemorrhagic shock-induced gastric mucosal injury in the rat. Gastroenterology 1987; 93:466-471
34. 34. Alexander JW, Boyce ST, Babcock GF, et al: The process of microbial translocation. Ann Surg 1990; 212:496-512
35. 35. Deitch EA, Winterton J, Berg R: The gut as a portal of entry for bacteremia. Ann Surg 1987; 205:681-692
36. 36. Munster AM, Smith-Meek M, Dickerson C, et al: Translocation: Incidental phenomenon or true pathology. Ann Surg 1993; 218:321-327
37. 37. Ravage ZB, Gomez HF, Czermak BJ, Watkins SA, Till GO: Mediators of microvascular injury in dermal burn wounds. Inflammation 1998; 22:619-629