Mutation in the threonine synthase gene results in an over-accumulation of soluble methionine in arabidopsis

Plant Physiology

Volumn 123, Issue 1, 2000, Pages 101-110

  Bartlem, Derek ^a   Lambein, Ingrid ^a   Okamoto, Takashi ^a   Itaya, Asuka ^a,b   Uda, Yukie ^a   Kijima, Fumiko ^a,c   Tamaki, Yuko ^a   Nambara, Eiji ^a   Naito, Satoshi ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

^b OKLAHOMA STATE UNIVERSITY   (United States)

^c Fukujuen CHA Research Center   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

2 PHOSPHOHOMOSERINE; AMINO ACID SYNTHESIS; BIOACCUMULATION; BIOCHEMICAL PATHWAY; CYSTATHIONINE GAMMA SYNTHASE; ENZYME ACTIVITY; ENZYME REGULATION; ENZYME SUBSTRATE; GENE MUTATION; GENETIC COMPLEMENTATION; MESSENGER RNA; METHIONINE; MUTANT; PHENOTYPE; THREONINE; THREONINE SYNTHASE;

ARABIDOPSIS; ESCHERICHIA COLI;

EID: 0034126920     PISSN: 00320889     EISSN: None     Source Type: Journal    
DOI: 10.1104/pp.123.1.101     Document Type: Article

References (46)

1. Aarnes H (1978) Regulation of threonine biosynthesis in barley seedlings (Hordeum vulgare L). Planta 140: 185-192
2. Alix J (1982) Molecular aspects of the in vivo and in vitro effects of ethionine, an analog of methionine. Microbiol Rev 46: 281-295
3. Anderson JW (1990) Sulfur metabolism in plants. In BJ Miflin, PJ Lea, eds, The Biochemistry of Plants: A Comprehensive Treatise, Vol 16. Academic Press, London, pp 327-381
4. Bartlem D, Tamaki Y, Naito S (1999) Genomic sequence of the Arabidopsis threonine synthase gene (accession no. AB027151) (PGR 99-108). Plant Physiol 120: 1205
5. Bell CJ, Ecker JR (1994) Assignment of 30 microsatellite loci to the linkage map of Arabidopsis. Genomics 19: 137-144
6. Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72: 248-254
7. Bryan JK (1980) Synthesis of the aspartate family and branched-chain amino acids. In BJ Miflin, ed, The Biochemistry of Plants: A Comprehensive Treatise, Vol 5. Academic Press, London, pp 403-452
8. Bryan JK (1990) Advances in the biochemistry of amino acid biosynthesis. In BJ Miflin, PJ Lea, eds, The Biochemistry of Plants: A Comprehensive Treatise, Vol 16. Academic Press, London, pp 161-195
9. Chattopadhyay MK, Ghosh AK, Sengupta S (1991) Control of methionine biosynthesis in Escherichia coli K12: a closer study with analogue-resistant mutants. J Gen Microbiol 137: 685-691
10. Chiang PK, Gordon RK, Tal J, Zeng GC, Doctor BP, Pardhasaradhi K, McCann PP (1996) S-Adenosyl-methionine and methylation. FASEB J 10: 471-480
11. Chiba Y, Ishikawa M, Kijima F, Tyson RH, Kim J, Yamamoto A, Nambara E, Leustek T, Wallsgrove RM, Naito S (1999) Evidence for autoregulation of cystathionine γ-synthase mRNA stability in Arabidopsis. Science 286: 1371-1374
12. Creason GL, Madison JT, Thompson JF (1985) Soybeans and radish leaves contain only one of the sulfonium diastereoisomers of S-adenosylmethionine. Phytochemistry 24: 1151-1155
13. Curien G, Dumas R, Ravanel S, Douce R (1996) Characterization of an Arabidopsis thaliana cDNA encoding an S-adenosylmethionine-sensitive threonine synthase: threonine synthase from higher plants. FEBS Lett 390: 85-90
14. Curien G, Job D, Douce R, Dunas R (1998) Allosteric activation of Arabidopsis threonine synthase by S-adenosylmethionine. Biochemistry 37:13212-13221
15. Davis RW, Botsein D, Roth JR (1980) Advanced Bacterial Genetics. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY
16. Feinberg AP, Vogelstein B (1984) A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. Anal Biochem 137: 266-267
17. Feldmann KA, Marks MD (1987) Agrobacterium mediated-transformation of germinating seeds of Arabidopsis thaliana: a non-tissue-culture approach. Mol Gen Genet 208: 1-9
18. Fujiwara T, Hirai MY, Chino M, Komeda Y, Naito S (1992) Effects of sulfur nutrition on expression of the soybean seed storage protein genes in transgenic petunia. Plant Physiol 99: 263-268
19. Giovanelli J, Mudd SH, Datko AH (1980) Sulfur amino acids in plants. In BJ Miflin, ed, The Biochemistry of Plants: A Comprehensive Treatise, Vol 5. Academic Press, London, pp 453-505
20. Giovanelli J, Mudd SH, Datko AH (1985) Quantitative analysis of pathways of methionine metabolism and their regulation in Lemna. Plant Physiol 78: 555-560
21. Giovanelli J, Mudd SH, Datko AH (1988) In vivo regulation of threonine and isoleucine biosynthesis in Lemna paucicostata Hegelm. 6746. Plant Physiol 86: 369-377
22. Giovanelli J, Veluthambi K, Thompson GA, Mudd SH, Datko AH (1984) Threonine synthase of Lemna paucicostata Hegelm. 6746. Plant Physiol 76: 285-292
23. Hofmann K, Bucher P, Falquet L, Bairoch A (1999) The PROSITE database, its status in 1999. Nucleic Acids Res 27: 215-219
24. Inaba K, Fujiwara T, Hayashi H, Chino M, Komeda Y, Naito S (1994) Isolation of an Arabidopsis thaliana mutant mto1 that overaccumulates soluble methionine: temporal and spatial patterns of soluble methionine accumulation. Plant Physiol 104: 881-887
25. Ishikawa M, Obata F, Kumagai T, Ohno T (1991) Isolation of mutants of Arabidopsis thaliana in which accumulation of tobacco mosaic virus coat protein is reduced to low levels. Mol Gen Genet 230: 33-38
26. Kim J, Leustek T (2000) Repression of cystathionine γ-synthase in Arabidopsis thaliana produces partial methionine auxotrophy and developmental abnormalities. Plant Sci 151: 9-18
27. Konieczny A, Ausubel FM (1993) A procedure for mapping Arabidopsis mutations using co-dominant ecotype-specific PCR-based markers. Plant J 4: 403-410
28. Laber B, Maurer W, Hanke C, Grafe S, Ehlert S, Messerschmidt A, Clausen T (1999) Characterization of recombinant Arabidopsis thaliana threonine synthase. Eur J Biochem 263: 212-221
29. Laemmli UK (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227: 680-685
30. Lister C, Dean C (1993) Recombinant inbred lines for mapping RFLP and phenotypic markers in A. thaliana. Plant J 4: 745-750
31. Madison JT, Thompson JF (1976) Threonine synthetase from higher plants: stimulation by S-adenosylmethionine and inhibition by cysteine. Biochem Biophys Res Commun 71: 684-691
32. Madison JT, Thompson JF (1988) Characterization of soybean tissue culture cell lines resistant to methionine analogs. Plant Cell Rep 7: 473-476
33. Malumbres M, Mateos LM, Lumbreras MA, Guerrero C, Martin JF (1994) Analysis and expression of the thrC gene of Brevibacterium lactofermentum and characterization of the encoded threonine synthase. Appl Environ Microbiol 60: 2209-2219
34. Matthews BF (1999) Lysine, threonine and methionine biosynthesis. In BK Singh, ed, Plant Amino Acids: Biochemistry and Biotechnology. Marcel Dekker, New York, pp 205-225
35. Murray MG, Thompson WF (1980) Rapid isolation of high molecular weight plant DNA. Nucleic Acids Res 8: 4321-4325
36. Peleman J, Saito K, Cottyn B, Engler G, Seurinck J, Van Montagu M, Inze D (1989) Structure and expression analyses of the S-adenosylmethionine synthetase gene family in Arabidopsis thaliana. Gene 84: 359-269
37. Ravanel S, Gakiere B, Job D, Douce R (1998a) The specific features of methionine biosynthesis and metabolism in plants. Proc Natl Acad Sci USA 95: 7805-7812
38. Ravanel S, Gakiere B, Job D, Douce R (1998b) Cystathionine γ-synthase from Arabidopsis thaliana: purification and biochemical characterization of the recombinant enzyme overexpressed in Escherichia coli. Biochem J 331: 639-648
39. Rogers EE, Ausubel FM (1997) Arabidopsis enhanced disease susceptibility mutants exhibit enhanced susceptibility to several bacterial pathogens and alterations in PR-1 gene expression. Plant Cell 9: 305-316
40. Rognes SE, Wallsgrove RM, Kueh JSH, Bright SWJ (1986) Effects of exogenous amino acids on growth and activity of four aspartate pathway enzymes in barley. Plant Sci 43: 45-50
41. Sambrook J, Fritsch EF, Maniatis T (1989) Molecular Cloning: A Laboratory Manual, Ed 2. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY
42. Singh BK (1999) Biosynthesis of valine, lysine and isoleucine. In BK Singh, ed, Plant Amino Acids: Biochemistry and Biotechnology. Marcel Dekker, New York, pp 227-247
43. Tabe L, Higgins TJV (1998) Engineering plant protein composition for improved nutrition. Trends Plant Sci 3: 282-286
44. Thoen A, Rognes SE, Aarnes H (1978) Biosynthesis of threonine from homoserine in pea seedlings: II. Threonine synthase. Plant Sci Lett 13: 113-119
45. Thompson GA, Datko AH, Mudd SH (1982a) Methionine synthesis in Lemna: studies on the regulation of cystathionine γ-synthase, O-phosphohomoserine sulhydrylase, and O-acetylserine sulfhydrylase. Plant Physiol 69: 1077-1083
46. Thompson GA, Datko AH, Mudd SH (1982b) Methionine synthesis in Lemna: inhibition of cystathionine γ-synthase by propargylglycine. Plant Physiol 70: 1347-1352