The combined pituitary function test in children: An evaluation of the clinical usefulness of TRH and LHRH stimulation tests through a retrospective analysis of one hundred and twenty six cases

Clinical Endocrinology

Volumn 52, Issue 6, 2000, Pages 727-733

  Westwood, Marie E ^a   Butler, G E ^a   McLellan, A C ^a   Barth, J H ^a  

^a LEEDS GENERAL INFIRMARY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCAGON; GONADORELIN; GONADOTROPIN; PROTIRELIN; THYROTROPIN; THYROXINE;

ADOLESCENT; ARTICLE; CHILD; CHILDHOOD DISEASE; DIAGNOSTIC VALUE; ENDOCRINE FUNCTION TEST; FEMALE; GONADORELIN TEST; GONADOTROPIN BLOOD LEVEL; GROWTH RETARDATION; HUMAN; HYPOPITUITARISM; HYPOTHALAMUS HYPOPHYSIS GONAD SYSTEM; HYPOTHALAMUS HYPOPHYSIS THYROID SYSTEM; LUTEINIZING HORMONE RELEASE; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTIRELIN TEST; SHORT STATURE; THYROTROPIN RELEASE; THYROXINE BLOOD LEVEL;

ADOLESCENT; AREA UNDER CURVE; CHILD; CHILD, PRESCHOOL; EVALUATION STUDIES; FEMALE; GONADOTROPIN-RELEASING HORMONE; GROWTH DISORDERS; HUMANS; HYPOPITUITARISM; MALE; PITUITARY FUNCTION TESTS; PREDICTIVE VALUE OF TESTS; RETROSPECTIVE STUDIES; STATISTICS, NONPARAMETRIC; STIMULATION, CHEMICAL; THYROTROPIN; THYROTROPIN-RELEASING HORMONE; THYROXINE;

EID: 0034126710     PISSN: 03000664     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2265.2000.00996.x     Document Type: Article

References (23)

1. Barth, J.H., Seth, J., Howlett, T.A. & Freedman D.B. (1995) A survey of endocrine function testing by clinical biochemistry laboratories in the UK. Annals of Clinical Biochemistry, 32, 442-449.
2. Bevan, J.S., Burke, C.W., Esiri, M.M., Adams, C.B.T., Ballabio, M., Nissim, M. & Faglia, G. (1989) Studies of two thyrotrophin secreting pituitary adenomas: evidence for dopamine receptor deficiency. Clinical Endocrinology, 31, 59-70.
3. Burke, C.W. (1992) The pituitary megatest: Outdated? Clinical Endocrinology, 36, 133-134.
4. Chaussain, J.L., Garnier, P.E., Binet, E., Vassal, J., Scholler, R. & Job, J.C. (1974) Effect of synthetic luteinizing hormone-releasing hormone (LH-RH) on the release of gonadotrophins in hypophso-gonadal disorders of children and adolescents. III. Hypopituitarism. Journal of Clinical Endocrinology and Metabolism, 38, 58-63.
5. Davies, M.J. & Hewlett, T.A. (1996) A survey of the current methods used in the UK to assess pituitary function. Journal of the Royal Society of Medicine, 89, 159P-164P.
6. Donald, R.A. (1990) The assessment of pituitary function. Clinical Biochemistry, 23, 23-30.
7. Faglia, G., Bitensky, L., Pinchera, A., Ferrari, C., Paracchi, A., Beck-Peccoz, P., Ambrosi, B. & Spada, A. (1979) Thyrotrophin secretion in patients with central hypothyroidism: Evidence for reduced biological activity of immunoreactive thyrotrophin. Journal of Clinical Endocrinology and Metabolism, 48, 989-998.
8. Foster, C.M., Hopwood, N.J., Beitins, I.Z., Mendes, T.M., Kletter, G.B. & Kelch, R.P. (1992) Evaluation of gonadotropin responses to synthetic gonadotropin-releasing hormone in girls with idiopathic hypopituitarism. The Journal of Pediatrics, 121, 528-532.
9. Ghai, K., Cara, J.F. & Rosenfield, R.L. (1995) Gonadotropin releasing hormone agonist (Nafarelin) test to differentiate gonadotropin deficiency from constitutionally delayed puberty in teenage boys - a clinical research center study. Journal of Clinical Endocrinology and Metabolism, 80, 2980-2986.
10. Gruneiro-Papendieck, L., Iorcansky, S., Rivarola, M.A., Heinrich, J.J., Martinez, A. & Bergada, C. (1982) Patterns of TSH response to TRH in children with hypopituitarism. The Journal of Pediatrics, 100, 387-392.
11. Gruneiro-Papendieck, L., Chiesa, A., Martinez, A., Heinrich, J.J. & Bergada, C. (1997) Nocturnal TSH surge and TRH test response in the evaluation of thyroid axis in hypothalamic pituitary disorders in childhood. Hormone Research, 50, 252-257.
12. Hagen, C., Hangaard, J., Bjerre, P., Schroder, H.D. & Rasmussen, J.N. (1990) Diagnosis of pituitary adenomas and pituitary insufficiency. Scandinavian Journal of Clinical Laboratory Investigation, Suppl. 202, 99-102.
13. Hall, R. (1989) Thyroid. In Fundamentals of Clinical Endocrinology (ed. R. Hall & M. Besser), pp. 82. Churchill Livingston, Edinburgh.
14. Harsoulis, P., Marshall, J.C., Kuku, S.F., Burke, C.W., London, D.R. & Fraser, T.R. (1973) Combined test for assessment of anterior pituitary function. British Medical Journal, 4, 326-329.
15. Job, J.C., Chaussain, J.L., Garnier, P.E. & Toublanc, J.E. (1976) Effects of synthetic luteinizing hormone-releasing hormone on the release of gonadotrophins in hypophyso-gonadal disorders of children and adolescents. VII. Constitutional delay of puberty in males. The Journal of Pediatrics, 88, 494-498.
16. Job, J.C., Chaussain, J.L. & Garnier, P.E. (1977) The use of luteinizing hormone-releasing hormone in paediatric patients. Hormone Research, 8, 171-187.
17. Ning, C., Jiang, Q., Wei, H., Wang, S. & Wang, M. (1992) Hypothalamic-pituitary function assessment in children by a combined stimulation test. Journal of Tongji Medical University, 12, 219-222.
18. Pavord, S.R., Girach, A., Price, D.E., Absalom, S.R., Falconer-Smith, J. & Howlett, T.A. (1992) A retrospective audit of the combined pituitary function test, using the insulin stress test, TRH and GnRH in a district laboratory. Clinical Endocrinology, 36, 135-139.
19. Savage, M.O., Preece, M.A., Cameron, N., Jones, J., Theintz, G., Penfold, J.L. & Tanner, J.M. (1981) Gonadotrophin response to LH-RH in boys with delayed growth and adolescence. Archives of Disease in Childhood, 56, 552-556.
20. Schmidt, D.N. & Wallace, K. (1998) How to diagnose hypopituitarism. Postgraduate Medicine, 104, 77-87.
21. Wu, F.C.W., Butler, G.E., Kelnar, C.J.H., Stirling, H.F. & Huhtaniemi, I. (1991) Patterns of pulsatile luteinising hormone and follicle stimulating hormone secretion in prepubertal (mid-childhood) boys and girls and patients with idiopathic hypogonadotrophic hypogonadism (Kallmann's Syndrome): A study using an ultrasensitive time-resolved immunofluorimetric assay. Journal of Clinical Endocrinology, 72, 1229-1237.
22. Wu, F.C.W., Brown, D.C., Butler, G.E., Stirling, H.F. & Kelnar, C.J.H. (1993) Early morning plasma testosterone is an accurate predictor of imminent pubertal development in prepubertal boys. Journal of Clinical Endocrinology and Metabolism, 76, 26-31.
23. Yeh, J., Rebar, R.W., Liu, J.L. & Yen, S.S.C. (1989) Pituitary function in isolated gonadotrophin deficiency. Clinical Endocrinology, 31, 375-387.