Steroidogenic alterations in testes and sera of rats exposed to trichloroethylene (TCE) by inhalation

Human and Experimental Toxicology

Volumn 19, Issue 2, 2000, Pages 117-121

  Kumar, P ^a   Prasad, A K ^a   Dutta, K K ^a  

^a CSIR INDIAN INSTITUTE OF TOXICOLOGY RESEARCH   (India)

Author keywords

17 hydroxy steroid dehydrogenase; Inhalation; Rat; Testes; Testosterone; Trichloroethylene

Indexed keywords

ANESTHETIC AGENT; ASCORBIC ACID; CHOLESTEROL; GLUCOSE 6 PHOSPHATE DEHYDROGENASE; ORGANIC SOLVENT; TESTOSTERONE; TESTOSTERONE 17BETA DEHYDROGENASE; TRICHLOROETHYLENE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CLEANING; CONTROLLED STUDY; ENZYME ACTIVITY; HORMONE SYNTHESIS; MALE; MALE GENITAL SYSTEM; NONHUMAN; PRIORITY JOURNAL; RAT; SPERMATOZOON COUNT; SPERMATOZOON MOTILITY; STEROIDOGENESIS; TESTIS; TESTOSTERONE BLOOD LEVEL; TESTOSTERONE SYNTHESIS;

ANIMALIA;

EID: 0034126247     PISSN: 09603271     EISSN: None     Source Type: Journal    
DOI: 10.1191/096032700678815657     Document Type: Article

References (21)

1. Toxicology profile for Trichloroethylene. U.S. Department of Public and Human Health Services. Agency for Toxicity Substances Disease Registry (1995) Atlanta, Georgia, USA.
2. Laham S. Studies on placental transfer of TCE. Ind Med 1970; 39: 46-49.
3. Goldberg SJ et al. An association of human congenital cardiac malformations and drinking water TCE contamination. Am J Cardiol 1990; 16: 155-164.
4. Tola S et al. A cohort study on occupational workers exposed to TCE. J Occup Med 1980; 22: 737-740.
5. Pradeep Kumar et al. Fertility and general reproductive studies in TCE exposed male rats. Fertility and Reproduction 1998. Communicated.
6. Dutta KK et al. Inhalation toxicity studies of Methyl isocyanate (MIC) in rats: Part-1 Pulmonary, pathological and genotoxicity evaluation. Ind J Exp Biol 1988; 26: 177-182.
7. Prasad AK et al. Effect of dermal application of Hexachloro-cyclohexane on male reproductive system of rat. Human & Experimental Toxicology 1995; 14: 484-488.
8. Freund M, Carol B. Factors affecting hemocytometer counts of sperm concentration in human semen. J Toxicol Environ Hlth 1993; 38: 393-398.
9. Srivastava S, Srivastava SP. Effect of di(2-ethylhexyl) pthalate on 17 β-hydroxy steroid dehydrogenase. Toxicol Lett 1991; 57: 235-239.
10. Lowry OH et al. Protein measurement with the Folin Phenol reagent. J Biol Chem 1951; 193: 265-275.
11. Zlatkis A et al. A new method for the direct determination of serum cholesterol. J Lab Clin Med 1953; 41: 436-492.
12. Sikic P et al. Effect of Ascorbic acid on the toxicity of L-tryptophan. Arch Biochem Biophys 1977; 179: 663-671.
13. Lohr GW, Walter HD. Glucose-6-P dehydrogenase. In: Bergmeyer HU (ed), Methods of Enzymatic Analysis 1974. 642-643.
14. Fischer RA. In Fischer (ed), Statistical Methods for Research Workers 11th edition, London: Oliver and Boyd, 1950.
15. Mckern K. The pentose-phosphate pathway, steroidogenesis and protein synthesis. Biochem Biophys Acta 1965; 100: 612-615.
16. Perlman PL. The functional significance of testis cholesterol and androgen biosynthesis following hypophysectomy and cryptorchidism. Endocrinology 1950; 46: 341-343.
17. Saxena DK et al. The effect of lead exposure on the testes of growing rats. Exp Pathol 1987; 31: 249-252.
18. Johnson AD et al. The effect of antispermatogenic and hormone treatments on testicular cholesterol. Fed Proc 1967; 26: 645-646.
19. Davis JT and Coniglio JG. The effect of cryptorchidism, cadmium and antispermatogenic drugs on fatty acid composition of rat testes. J Reprod Fertility 1967; 14: 407-410.
20. Ray A et al. Effect of Quinalphos on testicular steroidogenesis in rats. Andrologia 1988; 20: 163-168.
21. Donell L et al. Testosterone promotes the conversion of round spermatids between stages VII and VIII of the rat spermatogenic cycle. Endocrinology 1994; 135: 2608-2614.