Role of the input/output relation of sinoatrial myocytes in cholinergic modulation of heart rate variability

Journal of Cardiovascular Electrophysiology

Volumn 11, Issue 5, 2000, Pages 522-530

  Rocchetti, Marcella ^d   Malfatto, Gabriella ^a   Lombardi, Federico ^b   Zaza, Antonio ^c  

^a ISTITUTO AUXOLOGICO ITALIANO   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

^c UNIVERSITY OF MILANO BICOCCA   (Italy)

^d NONE

Author keywords

Acetylcholine; Autonomic nervous system; Heart rate variability; Sinus node

Indexed keywords

ACETYLCHOLINE;

ACTION POTENTIAL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTONOMIC NERVOUS SYSTEM; CHOLINERGIC TRANSMISSION; DEPOLARIZATION; HEART RATE; HEART RATE VARIABILITY; MUSCLE CELL; NONHUMAN; PACEMAKER; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SINOATRIAL CONDUCTION; SINUS NODE;

EID: 0034125444     PISSN: 10453873     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1540-8167.2000.tb00005.x     Document Type: Article

References (15)

1. 1. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology: Heart rate variability. Standards of measurement, physiological interpretation and clinical use. Circulation 1996;93:1043-1065.
2. 2. DiFrancesco D, Ducouret P, Robinson RB: Muscarinic modulation of cardiac rate at low acetylcholine concentrations. Science 1989; 243:669-671.
3. 2+ and hyperpolarization-activated currents to autonomic agonists in the rabbit sinoatrial node. J Physiol 1996;491: 347-355.
4. 4. Wilders R, Jongsma HJ: Beating irregularity of single pacemaker cells isolated from the rabbit sinoatrial node. Biophys J 1993;65: 2601-2613.
5. r) by adenosine in rabbit sinoatrial myocytes. Circulation 1996;94:734-741.
6. 6. Campbell GD, Edwards FR, Hirst GDS, O'Shea JE: Effects of vagal stimulation and applied acetylcholine on pacemaker potentials in the guinea-pig heart. J Physiol 1989;415:57-68.
7. 7. Wickman K, Nemec J, Gendler SJ, Clapham DE: Abnormal heart rate regulation in GIRK4 knockout mice. Neuron 1998;20:103-114.
8. 8. Tsuji H, Venditti FJJ, Manders ES, Evans JC, Larson MG, Feldman CL, Levy D: Determinants of heart rate variability. J Am Coll Cardiol 1996;28:1539-1546.
9. 9. Binkley PF, Haas GJ, Starling RC, Nunziata E, Hatton PA, Leier CV, Cody RJ: Sustained augmentation of parasympathetic tone with angiotensin-converting enzyme inhibition in patients with congestive heart failure. J Am Coll Cardiol 1993;21:655-661.
10. 10. Coumel P, Maison-Blanche P, Catuli D: Heart rate and heart rate variability. In Malik M, Camm AJ, eds: Heart Rate Variability. Futura Publishing Co., Armonk, NY, 1995, pp. 207-222.
11. 11. Zaza A, Micheletti M, Brioschi A, Rocchetti M: Ionic currents during sustained pacemaker activity in rabbit sino-atrial myocytes. J Physiol 1997;505:677-688.
12. 12. Lombardi F, Malliani A, Pagani M, Cerutti S: Heart rate variability and its sympatho-vagal modulation. Cardiovasc Res 1996;32:208-216.
13. 13. MacKaay AJC, Opthof T, Bleeker WK, Jongsma HJ, Bouman LN: Interaction of adrenaline and acetylcholine on cardiac pacemaker function. J Pharmacol Exp Ther 1980;214:417-422.
14. 14. Jalife J: Mutual entrainment and electrical coupling as mechanisms for synchronous firing of rabbit sino-atrial pace-maker cells. J Physiol 1984;356:221-243.
15. 15. Verheijck EE, Wilders R, Joyner RW, Golod DA, Kumar R, Jongsma HJ, Bouman LN, van Ginneken A: Pacemaker synchronization of electrically coupled rabbit sinoatrial node cells. J Gen Physiol 1998;111:95-112.