Comparison of the acute hematotoxicity of 2-butoxyethanol in male and female F344 rats

Human and Experimental Toxicology

Volumn 19, Issue 3, 2000, Pages 185-192

  Ghanayem, B I ^a   Ward, S M ^a   Chanas, B ^a   Nyska, A ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

2 butoxyethanol; Erythrocytes morphology; Hematotoxicity; Male and female F344 rats

Indexed keywords

2 BUTOXYETHANOL; HEMOGLOBIN BETA CHAIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD ANALYSIS; BLOOD TOXICITY; BODY WEIGHT; CELL STRUCTURE; CELL SWELLING; CONTROLLED STUDY; DISEASE SEVERITY; ERYTHROCYTE; ERYTHROCYTE AGGREGATION; ERYTHROCYTE VOLUME; FEMALE; HEMATOCRIT; HEMOLYSIS; MALE; MICROSCOPY; NONHUMAN; PRIORITY JOURNAL; RAT; SEX DIFFERENCE; SPHEROCYTOSIS; SPLEEN WEIGHT; THROMBOSIS;

ANIMALIA; RODENTIA;

EID: 0034125362     PISSN: 09603271     EISSN: None     Source Type: Journal    
DOI: 10.1191/096032700678827744     Document Type: Article

References (30)

1. United States International Trade Commission (USITC). Organic Chemicals: United States Production and Sales, 1992. USITC Pub. No 2720. US International Trade Commission, Washington, DC, USA.
2. Bartnik FG et al. Percutaneous absorption, metabolism, and hemolytic activity of n-butoxyethanol. Fund Appl Toxicol 1987; 8: 59-70.
3. Carpenter PC et al. The toxicity of butyl cellosolve solvent. Arch Ind Health 1995; 14: 114-131.
4. Ghanayem BI, Burka LT, Matthews HB. Metabolic basis of ethylene glycol monobutyl ether (2-butoxyethanol) toxicity: Role of alcohol and aldehyde dehydrogenases. The Journal of Pharmacology and Experimental Therapeutics 1987; 242: 222-231.
5. Ghanayem BI. An overview of the hematotoxicity of ethylene glycol ethers. Occupational Medicine 1996; 2: 253-268.
6. Udden MM, Paton CS. Hemolysis and deformability of erythrocytes exposed to butoxyacetic acid, a metabolite of 2-butoxyethanol: I. Sensitivity in rats and resistance in normal humans. J Appl Toxicol 1994; 14: 91-96.
7. Rambourg-Schepens MO et al. Severe ethylene glycol butyl ether poisoning: Kinetics and metabolism pattern. Human Toxicol 1988; 7: 187-189.
8. Gijsenbergh FP, Jenco M, Veulemans H. Acute butylglycol intoxication: A case report. Human Toxicology 1989; 8: 243-245.
9. Corley RA et al. Physiologically based pharmacokinetics and the dermal absorption of 2-butoxyethanol vapor by humans. Toxicol Appl Pharmacol 1997; 39: 120-130.
10. Johanson G. Physiologically based pharmacokinetics modeling of inhaled 2-butoxyethanol in man. Toxicol Lett 1986; 34: 23-31.
11. Haufroid V et al. Biological monitoring of workers exposed to low levels of 2-butoxyethanol. Int Arch Occup Environ Health 1997; 70: 232-236.
12. Angerer et al. Occupational chronic exposure to organic solvents. XIII. Glycolether exposure during the production of varnishes. Occup Environ Health 1990; 62: 123-126.
13. Sohnlein B et al. Occupational chronic exposure to organic solvents. XIV. Examinations concerning the evaluation of a limit value for 2-ethoxyethanol and 2-ethoxyethyl acetate and the genotoxic effects of these glycol ethers. Int Arch Occup Environ Health 1993; 64; 479-484.
14. Ghanayem BI, Sullivan CA. Assessment of the hemolytic activity of 2-butoxyethanol and its major metabolite, butoxyacetic acid, in various mammals including humans. Hum Exp Toxicol 1993; 12: 305-311.
15. National Toxicology Program Toxicology and carcinogenesis studies of 2-Butoxyethanol (CAS No. 111-76-2) in F344/N rats and B6C3F1 mice (inhalation studies). Technical Report Series 484, Department of Health and Human Services, Public Health Service, Bethesda, MD 1999.
16. Nyska A et al. Disseminated thrombosis and bone infarction in female rats following inhalation exposure to 2-Butoxyethanol. Toxicol Pathol 1999; 27: 287-194.
17. Nyska A, Maronpot RR, Ghanayem BI. Ocular thrombosis and retinal degeneration induced in female F334 rats by 2-butoxyethanol. Hum Exp Toxicol 1999; 18: 577-582.
18. NIH Guide for the Care and Use of Laboratory Animals 1985; U.S. Department of Health and Human Services; Animal Resources Program, Division of Research Resources, National Institutes of Health, Bethesda, Maryland.
19. Udden MM. Hemolysis and deformability of erythrocytes exposed to butoxyacetic acid, a metabolite of 2-butoxyethanol II. Resistance in red blood cells from humans with potential susceptibility. J Appl Toxicol 1994; 14: 97-102.
20. Dill AJ et al. Toxicokinetics of inhaled 2-butoxyethanol and its major metabolite, 2-butoxyacetic acid, in F344 rats and B6C3F1 mice. Toxicol Appl Pharmacol 1998; 153: 227-242.
21. Aasmoe L, Winberg JO, Aarbakke J. The role of liver alcohol dehydrogenase isoenzymes in the oxidation of glycolethers in male and female rats. Toxicol Appl Pharmacol 1998; 150: 86-90.
22. Bessis M (Ed.). Blood Smears Reinterpreted. Springer International, PP 100; 1977.
23. Nathan DG, Shohet SB. Erythrocyte ion transport defects and hemolytic anemia: 'hydrocytosis' and 'descocytosis'. In: Weed RI, Jaffe RE, Miescher PA (eds): The red cell membrane. Grune and Stratton: New York 1971, P 133.
24. Wintrobe MM et al. Acquired coagulation disorders. In: Wintrobe, MM (ed.) Clinical hematology, 8th ed., Lea and Febiger, Philadelphia, 1981 pp. 1206.
25. Nikol S, Huehns TY, Keifmann R and Hofling B, Excessive Arterial Thrombi in Spherocytosis: A Case Report. Angiology 1997; 48: 743-748.
26. Hayag-Barin JE, Smith RE, Tucker Jr FC. Hereditary spherocytosis, thrombosis, and chronic pulmonary emboli: A case Report and Review of the Literature. Am J Hematology 1998; 57: 82-84.
27. Kaysser TM, Wandersee NJ, Bronson RT and Barker JE. Thrombosis and secondary hemochromatosis play major roles in the pathogenesis of jaundiced and spherocytic mice, murine models for hereditary spherocytosis. Blood 1997; 90: 4610-4619.
28. Obeifuna PC. Rouleax formation in sickle cell traits. J Trop Med Hyg 1991; 94: 42-44.
29. Morris CL, Rucknagel DL, Joiner CH. Deoxygenation-induced changes in sickle cell-sickle cell adhesion. Blood 1993; 81: 3138-3145.
30. Obeifuna PC, Photiades DP. Sickle discocytes form more rouleaux in vitro than normal erythrocytos. J Trop Med Hyg 1990; 3: 210-214.