Sensitivity to ethanol-induced motor incoordination in FAST and SLOW selectively bred mice

Pharmacology Biochemistry and Behavior

Volumn 66, Issue 2, 2000, Pages 241-247

  Boehm II, Stephen L ^a   Crabbe, John C ^a   Phillips, Tamara J ^a  

^a PORTLAND VA MEDICAL CENTER   (United States)

Author keywords

Correlated trait; Ethanol; Genetics; Locomotor stimulation; Motor incoordination; Rotarod; Selected mouse line; Stationary dowel

Indexed keywords

ALCOHOL;

ANIMAL EXPERIMENT; ARTICLE; ATAXIA; CONTROLLED STUDY; FEMALE; HEREDITY; INBRED STRAIN; LOCOMOTION; MALE; MOTOR COORDINATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SEX DIFFERENCE;

ANIMALS; ATAXIA; DRUG RESISTANCE; ETHANOL; FEMALE; LOCOMOTION; MALE; MICE; SPECIES SPECIFICITY;

EID: 0034125016     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0091-3057(00)00264-1     Document Type: Article

References (19)

1. 1B receptor null mutant mice is task-dependent: Implications for behavioral assessment of genetically altered mice. Behav. Neurosci. (in press).
2. Crabbe J.C. Sensitivity to ethanol in inbred mice. Genotypic correlations among several behavioral responses Behav. Neurosci. 97:1983;280-289.
3. Crabbe J.C., Gallaher E.J., Phillips T.J., Belknap J.K. Genetic determinants of sensitivity to ethanol in inbred mice. Behav. Neurosci. 108:1994;186-195.
4. Crabbe J.C., Kosobud A., Tam B.R., Young E.R., Deutsch C.M. Genetic selection of mouse lines sensitive (COLD) and resistant (HOT) to acute ethanol hypothermia. Alcohol Drug Res. 7:1987;163-174.
5. 1B serotonin receptors. Nat. Genet. 14:1996;98-101.
6. Crabbe J.C., Phillips T.J., Gallaher E.J., Crawshaw L.I., Mitchell S.R. Common genetic determinants of the ataxic and hypothermic effects of ethanol in BXD/Ty recombinant inbred inbred mice. Genetic correlations and quantitative trait loci J. Pharmacol. Exp. Ther. 277:1996;624-632.
7. Crabbe J.C., Phillips T.J., Kosobud A., Belknap J.K. Estimation of genetic correlation. Interpretation of experiments using selectively bred and inbred animals Alcohol Clin. Exp. Res. 14:1990;141-151.
8. Crabbe J.C., Young E.R., Deutsch C.M., Tam B.R., Kosobud A. Mice genetically selected for differences in open-field activity after ethanol. Pharmacol. Biochem. Behav. 27:1987;577-581.
9. Dudek B.C., Phillips T.J. Distinctions among sedative, disinhibitory, and ataxic properties of ethanol in inbred and selectivity bred mice. Psychopharmacology (Berlin). 101:1990;93-99.
10. Dudek B.C., Phillips T.J. Locomotor stimulant and intoxicant properties of methanol, ethanol, tertiary butanol and pentobarbital in long-sleep and short-sleep mice. Subst. Alcohol Actions/Misuse. 4:1983;31-36.
11. Dudek B.C., Phillips T.J., Hahn M.E. Genetic analyses of the biphasic nature of the alcohol dose-response curve. Alcohol Clin. Exp. Res. 15:1991;161-169.
12. Dunham N.W., Miya T.S. A note on a simple apparatus for detecting neurological deficit in rats and mice. J. Am. Pharm. Assoc. 46:1957;208-209.
13. Gallaher E.J., Parsons L.M., Goldstein D.B. The rapid onset of tolerance to ataxic effects of ethanol in mice. Psychopharmacology (Berlin). 78:1982;67-70.
14. Jones B.J., Roberts D.J. The quantitative measurement of motor inco-ordination in naive mice using an accelerating rotarod. J. Pharm. Pharmacol. 20:1967;302-304.
15. Phillips T.J., Lessov C.N., Harland R.D., Mitchell S.R. Evaluation of potential genetic associates between ethanol tolerance and sensitization in BXD/Ty Recombinant inbred Mice. J. Pharmacol. Exp. Ther. 277:1996;613-623.
16. Schafer G.L., Crabbe J.C. Sensitivity to ethanol-induced ataxia in HOT and COLD selected lines of mice. Alcohol Clin. Exp. Res. 20:1996;1604-1612.
17. Shen E.H., Dorow J.D., Huson M., Phillips T.J. Correlated responses to selection in FAST and SLOW mice. Effects of ethanol on ataxia, temperature, sedation, and withdrawal Alcohol Clin. Exp. Res. 20:1996;688-696.
18. Shen E.H., Harland R.D., Crabbe J.C., Phillips T.J. Bidirectional selective breeding for ethanol effects on locomotor activity. Characterization of FAST and SLOW Mice through selection generation 35 Alcohol Clin. Exp. Res. 19:1995;1234-1245.
19. Shen E.H., Phillips T.J. MK-801 potentiates ethanol's effects on locomotor activity in mice. Pharmacol. Biochem. Behav. 59:1998;135-143.