Glyceryl trinitrate treatment of chronic fissure in ano: One year's experience with 0.5% GTN paste

Journal of the Royal College of Surgeons of Edinburgh

Volumn 45, Issue 3, 2000, Pages 168-170

  Palazzo, F F ^a,b   Kapur, S ^a   Steward, M ^a   Cullen, P T ^a  

^a QUEEN ELIZABETH HOSPITAL   (United Kingdom)

^b ST BARTHOLOMEW S HOSPITAL   (United Kingdom)

Author keywords

Anal fissure; Glyceryl trinitrate (GTN)

Indexed keywords

GLYCERYL TRINITRATE;

ADOLESCENT; ADULT; AGED; ANUS FISSURE; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; FOLLOW UP; HEADACHE; HEALING; HUMAN; PATIENT COMPLIANCE;

ADMINISTRATION, TOPICAL; ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; CHRONIC DISEASE; DRUG ADMINISTRATION SCHEDULE; FEMALE; FISSURE IN ANO; FOLLOW-UP STUDIES; HUMANS; MALE; MIDDLE AGED; NITROGLYCERIN; TREATMENT OUTCOME;

EID: 0034124968     PISSN: 00358835     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (7)

1. Watson SJ, Kamm MA, Nicholls RJ, Phillips RKS. Topical glyceryl trinitrate in the treatment of chronic anal fissure. British Journal of Surgery 1996 83; 771-5
2. Khubchandani IT, Reed JF. Sequelae of internal sphincterotomy for chronic fissure in ano. British Journal of Surgery 1989 76; 431-4
3. Schouten WR, Briel JW, Auwerda JJA. Relationship between anal pressure and anodermal blood flow: the vascular pathogenesis of anal fissure. Gut 1994 34; S25
4. Lund JN, Scholefield JH. A randomised, prospective, double blind, placebo controlled trial of glyceryl trinitrate ointment in treatment of anal fissure. Lancet 1997 349; 11-4
5. Carapeti EA, Kamm MA, McDonald PJ, Chadwick SJD, Melville D, Phillips RKS. Randomised controlled trial shows that glyceryl trinitrate heals anal fissures, higher doses are not more effective, and there is a high recurrence rate. 1999 Gut 44; 727-30
6. Gorfine SR. Treatment of benign anal disease with topical nitroglycerin. Diseases of the Colon & Rectum 1995 38; 453-7
7. Lund JN, Scholefield JH. Follow-up of patients with chronic anal fissure treated with topical glyceryl trinitrate. Lancet 1998 352; 1681