Calcium pumps: Structural basis for and mechanism of calcium transmembrane transport

Current Opinion in Chemical Biology

Volumn 4, Issue 2, 2000, Pages 152-161

  Carafoli, Ernesto ^a   Brini, Marisa ^a  

^a UNIVERSITY OF PADOVA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE (CALCIUM);

CALCIUM TRANSPORT; CELL MEMBRANE; CELL MEMBRANE TRANSPORT; ENDOPLASMIC RETICULUM; PROTEIN STRUCTURE; REGULATORY MECHANISM; REVIEW;

EUKARYOTA;

EID: 0034124717     PISSN: 13675931     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1367-5931(99)00069-1     Document Type: Review

References (67)

1. Pedersen P.L., Carafoli E. Ion motive ATPases. II. Energy coupling and work output. Trends Biochem Sci. 12:1987;186-189.
2. Pedersen P.L., Carafoli E. Ion motive ATPases. I. Ubiquity, properties, and significance for cell function. Trends Biochem Sci. 12:1987;146-150.
3. Guerini D., Carafoli E. The Calcium Pumps. Carafoli E., Klee C.B. Calcium as a Cellular Regulator. 1999;249-278 Oxford University Press, Oxford.
4. 2+ extrusion from human red cells. Experientia Basel. 22:1966;364-368.
5. 2+)-ATPase from human erythrocyte membranes using a calmodulin affinity column. J Biol Chem. 254:1979;9955-9958.
6. 2+) ATPase of the erythrocyte membrane: reconstruction and effect of calmodulin and phospholipids. J Biol Chem. 256:1981;395-401.
7. Carafoli E. Calcium pump of the plasma membrane. Physiol Rev. 71:1991;129-153.
8. Carafoli E. Plasma membrane calcium ATPase: 15 years of work on the purified enzyme. FASEB J. 8:1994;993-1002.
9. Szasz I., Sarkadi B., Schubert A., Gardos E. Effects of lanthanum on calcium-dependent phenomena in human red cell. Biochim Biophys Acta. 512:1978;331-340.
10. 2+ pump of human erythrocytes. J Biol Chem. 263:1988;2905-2910.
11. 2+ binding sites. J Biol Chem. 268:1993;10252-10259.
12. 2+ pump using trypsin proteolysis. Biochemistry. 29:1990;8070-8076.
13. 2+ pump. Eur J Biochem. 204:1992;939-946.
14. 2+ path.
15. 2+ Atpase gene cause deafness in deafwaddler mice. Nat Genet. 19:1998;390-394. The deaf waddler mouse mutant is deaf and displays vestibular/motor imbalance. Mutations have been detected in the gene encoding PMCA2: in one of the mutants, an A→G transition causes a Gly→Ser substitution at the highly conserved position in the pump sequence. In another mutant, a 2 bp deletion causes a frameshift that produces a truncated pump. PMCA2 is localised to stereocilia and the basolateral wall of hair cells of the cochlea in wild-type mice, but is not detected in mice with the mutation producing the truncated pump.
16. 2+-ATPase isoform 2. J Biol Chem. 273:1998;18693-18696. PMCA2-null mice grow more slowly than heterozygous and wild-type mice, have difficulties in maintaining balance, and are deaf. Histological analysis of the cerebellum and inner ear shows an increased number of Purkinje neurons, a decreased thickness of the molecular layer, and a range of abnormalities in the inner ear (vestibular system and the organ of Corti).
17. Heim R., Hug M., Iwata T., Strehler E.E., Carafoli E. Microdiversity of human-plasma-membrane calcium-pump isoform 2 generated by alternative RNA splicing in the N-terminal coding region. Eur J Biochem. 205:1992;333-340.
18. Strehler E.E., Strehler-Page M.A., Vogel G., Carafoli E. mRNAs for plasma membrane calcium pump isoforms differing in their regulatory domain are generated by alternative splicing involving two internal donor sites in a single exon. Proc Natl Acad Sci USA. 86:1989;6908-6912.
19. 2+ ATPase. J Biol Chem. 268:1994;19717-19725.
20. 2+ pump. Biochemistry. 31:1992;11785-11792.
21. 2+ ATPase by selective calpain cleavage of the calmodulin binding domain. J Biol Chem. 264:1989;8289-8296.
22. 2+ pump. Biochemistry. 35:1996;3290-3296.
23. 2+ pump contains a site that interacts with its calmodulin binding domain. J Biol Chem. 266:1991;2930-2936.
24. 2+ pump interacts with the transduction domain of the enzyme. Protein Sci. 1:1992;1613-1621.
25. 2+ pump of the sarcoplasmic reticulum. Nature. 342:1989;90-92.
26. 2+ pump by protein kinase C reduces its interaction with calmodulin and with its pump receptor site. J Biol Chem. 269:1994;24298-24303.
27. 2+ increase within the limits necessary to block the apoptosis program, without reaching the overload levels that would otherwise cause toxic cell death.
28. 2+-mediated control of gene expression. It might act by mediating the transfer of transcription factors to the nucleus, or by controlling the phosphorylation state of other transcription factors directly within the nucleus.
29. Ebashi S., Lipmann F. Adenosine-triphosphate-linked concentration of calcium ions in a particular fraction of rabbit muscle. J Cell Biol. 14:1962;389-400.
30. Hasselbach W., Makinose M. Die Calcium Pumpe der 'Erschlaffungsgrana' des Muskles und ihre Abhangigkeitvon der ATP-Spaltung. Biochem Z. 333:1961;518-528. Title translation: The calcium pump of the "relaxing granules" of muscle and its dependence on ATP hydrolysis.
31. Marsh B.B. A factor modifying muscle fibre synaeresis. Nature. 167:1951;1065-1066.
32. MacLennan D.H. Purification and properties of an adenosine trisphosphatase from sarcoplasmic reticulum. J Biol Chem. 245:1970;4508-4518.
33. Heilmann C., Spamer C., Gerok W. The calcium pump in rat liver endoplasmic reticulum. J Biol Chem. 259:1984;11139-11144.
34. Heilmann C., Spamer C., Gerok W. Reaction mechanism of the calcium-transport ATPase in endoplasmic reticulum of rat liver. J Biol Chem. 260:1985;788-794.
35. 2+-activated ATPases in microsomes from human liver. J Biol Chem. 262:1987;7782-7789.
36. 2+-ATPase. J Biol Chem. 272:1997;28815-28818.
37. Inesi G. Sequential mechanism of calcium binding and traslocation in sarcoplasmic reticulum adenosine triphosphatase. J Biol Chem. 262:1987;16338-16342.
38. 2+ pump in reconstituted proteoliposomes. Biophys J. 64:1993;1232-1242.
39. 2+-ATPase and exogenous lipids. J Biol Chem. 269:1994;14268-14275.
40. 2+-ATPase from muscle sarcoplasmic reticulum. J Mol Biol. 187:1986;417-427.
41. Toyoshima C., Sasabe H., Stokes L.S. Three-dimensional cryo-electron microscopy of the calcium ion pump in the sarcoplasmic reticulum membrane. Nature. 362:1993;469-471.
42. 2+ from the lumen (the release site) with the cytoplasmic surface.
43. 2+ might induce a rearrangement of the TMSs, and is subsequently transmitted to the cytoplasmic domain through a structural change in the stalk. (However, see the text for the alternative possibility that the structural change reflects the binding of vanadate instead.) Significant changes around the putative ATP-binding site might be explained by the segmental movement of the cytoplasmic domains.
44. 2+ ATPase revealed by electron image analysis. Biophys J. 72:1997;997-1005.
45. 2+ATPase of the sarcoplasmic reticulum. Cell Motil Cytoskeleton. 14:1989;26-34.
46. 2+-ATPases expressed in COS-1 cells. Proc Natl Acad Sci USA. 85:1988;3314-3318.
47. 2+-ATPase of sarcoplasmic reticulum. J Biol Chem. 264:1989;13038-13042.
48. 2+-ATPase. Nature. 339:1989;476-478.
49. 2+-ATPase of sarcoplasmic reticulum. J Biol Chem. 265:1990;22223-22227.
50. 2+-ATPase of sarcoplasmic reticulum. J Biol Chem. 264:1989;21018-21023.
51. 2+-ATPase of sarcoplasmic reticulum. J Biol Chem. 265:1990;14088-14092.
52. Tada M., Kirchberger M.A., Katz A.M. Phosphorylation of a 22,000-dalton component of the cardiac sarcoplasmic reticulum by adenosine 3′:5′-monophosphate-dependent protein kinase. J Biol Chem. 250:1975;2640-2647.
53. 2+-ATPase of sarcoplasmic reticulum that affect functional association with phospholamban. J Biol Chem. 268:1993;2809-2815.
54. 2+-ATPase forms a functional interaction site with phospholamban. J Biol Chem. 274:1999;32855-32862.
55. + transport ATPase. J Membr Biol. 141:1994;1-6.
56. 2+ homeostasis in cardiac cells. Biosci Rep. 15:1995;341-349.
57. 2+ and thapsigargin. FEBS Lett. 336:1993;248-254.
58. 2+ ATPase inhibition. J Biol Chem. 273:1998;12994-12998.
59. 2+ transport ATPases by thapsigargin. J Biol Chem. 267:1992;12606-12613.
60. 2+-dependent ATPase from rabbit muscle sarcoplasmic reticulum, deduced from its complementary DNA sequence. Nature. 316:1985;396-400.
61. 2+-ATPase gene. J Biol Chem. 263:1988;15024-15031.
62. 2+-pump. J Biol Chem. 264:1989;18561-18568.
63. 2+-ATPase 3 gene. Biochem J. 318:1996;689-699.
64. Poch E., Leach S., Snape S., Cacic T., MacLennan D.H., Lytton J. Functional characterization of alternatively spliced human SERCA3 transcripts. Am J Physiol 275:C1449-C1458. 1998.
65. 2+ ATPase, are associated with Brody disease. Nat Genet. 14:1996;191-194.
66. 2+ signalling in epidermal cells.
67. Lytton J., Westlin M., Burk S.E., Shull G.E., MacLennan D.H. Functional comparison between isoforms of the sarcoplasmic or endoplasmic reticulum family of calcium pumps. J Biol Chem. 267:1992;14483-14489.