The clinical significance of thymidine kinase 1 measurement in serum of breast cancer patients using anti-TK1 antibody

International Journal of Biological Markers

Volumn 15, Issue 2, 2000, Pages 139-146

  He, Q ^a   Zou, L ^b   Zhang, P A ^b   Lui, J X ^b   Skog, S ^a   Fornander, T ^c  

^a KAROLINSKA INSTITUTE   (Sweden)

^b WUHAN UNIVERSITY   (China)

^c STOCKHOLM SÖDER HOSPITAL   (Sweden)

Author keywords

Breast cancer; Mono polyclonal antibody against TK1; S TK1; TK activity; TK1; Tumor marker; Tumor therapy

Indexed keywords

IDOXURIDINE; IODINE 125; MONOCLONAL ANTIBODY; POLYCLONAL ANTIBODY; THYMIDINE KINASE; TUMOR MARKER;

ARTICLE; BREAST CANCER; CONTROLLED STUDY; CYTOPLASM; DOT HYBRIDIZATION; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME BLOOD LEVEL; ENZYME SUBSTRATE; HUMAN; HUMAN CELL; HUMAN TISSUE; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY;

EID: 0034123681     PISSN: 03936155     EISSN: None     Source Type: Journal    
DOI: 10.1177/172460080001500203     Document Type: Article

References (33)

1. Kid S, Leung WC, Kaplan A. Distinctive molecular form of thymidine kinase in mitochondria of normal and bromodeoxyuridine resistant HeLa cells. Eur J Biochem 1973; 39: 43-8.
2. Kid S. Thymidine kinase. Microbiol Sci 1985; 2: 369-75.
3. Brent TP. Periodicity of DNA synthetic enzymes during the HeLa cell cycle. Cell Tissue Kinet 1971; 4: 297-305.
4. Stuart P, Ito O, Conrad SE. Induction of cellular thymidine kinase occurs at the mRNA level. Mol Cell Biol 1985; 5: 1490-7.
5. Sherley JL, Kelly TJ. Regulation of human thymidine kinase during the cell cycle. J Biol Chem 1988; 263: 8350-8.
6. He Q, Skog S, Tribukait B. Cell cycle related studies on thymidine kinase and its isoenzymes in Ehrlich ascites tumours. Cell Prolif 1991; 24: 3-14.
7. Kauffman MG, Kelly TJ. Cell cycle regulation of thymidine kinase: residues near the carboxyl terminus are essential for the specific degradation of the enzyme at mitosis. Mol Cell Biol 1991; 11: 2538-46.
8. Hengstschläger M, Knöfler M, Müllner EW, et al. Different regulation of thymidine kinase during the cell cycle of normal versus DNA tumor virus-transformed cells. J Biol Chem 1994; 19: 13836-42.
9. Weissman SM, Smellie RMS, Paul J. Studies on the biosynthesis of deoxyribonucleic acid by extracts of mammalian cells. IV. The phosphorylation of thymidine. BBA 1960; 45: 101-10.
10. Ellimes PH, Hayman RJ, Van der Weyden MB. Plasma thymidine kinase in megaloblastic anaemia. Br J Haematol 1980; 44: 167-8.
11. Gronowitz JS, Källander CFR. Optimized assay for thymidine kinase and its application to the detection of antibodies against herpes simplex virus type-1 and 2-induced thymidine kinase. Infect Immun 1980; 29: 425-34.
12. Gronowitz SJ, Hagberg H, Källander CFR, et al. The use of serum deoxythymidine kinase as a prognosis marker, and in the monitoring of patients with non-Hodgkin's lymphoma. Br J Cancer 1983; 47: 487-95.
13. Gronowitz SJ, Källander CFR, Diderholm H, et al. Application of an in vitro assay for serum thymidine kinase: results on viral disease and malignancies in humans. Int J Cancer 1984; 33: 5-12.
14. Musto P, Bodenizza C, Falcone A, et al. Prognostic relevance of serum thymidine kinase in primary myelodysplastic syndromes: relationship to development of acute myeloid leukaemia. Br J Haematol 1995; 90: 125-30.
15. 5. Sadamori N, Ichiba M, Mine M, et al. Clinical significance of serum thymidine kinase in adult T-cell leukaemia and acute myeloid leukaemia. Br J Haematol 1995; 90: 100-5.
16. Suki S, Swan F Jr, Tucker S, et al. Risk classification for large cell lymphoma using lactate dehydrogenase, beta-2 microglobulin, and thymidine kinase. Leuk Lymphoma 1995; 18: 87-92.
17. Sadamori N. Clinical and biological significance of serum tumor markers in adult T-cell leukemia. Leuk Lymphoma 1996; 2285: 415-19.
18. Hallek M, Langenmayer I, Nerl C, et al. Elevated serum thymidine kinase levels identify a subgroup at high risk of disease progression in early, nonsmoldering chronic lymphocytic leukemia. Blood 1999; 93: 1732-7
19. Poley S, Stieber P, Nussler V, et al. Serum thymidine kinase in non-Hodgkin lymphomas with special regard to multiple myeloma. Anticancer Res 1997; 17: 3025-9.
20. Micke O, Schafer U, Wormann B, et al. Circadian variations of interleukin-2 receptors, serum thymidine kinase and beta-2 microglobulin in patients with non-Hodgkin's lymphoma and normal controls. Anticancer Res 1997; 17: 3007-10.
21. O'Neill KL, Hoper M, Odling-Smee GM. Can thymidine kinase levels in breast tumors predict disease recurrence? J Natl Cancer Inst 1992; 84: 1825-8.
22. Peley G, Bezzegh A, Besznyak I, et al. Correlation of biochemical tumor markers with conventional pathological features in primary breast cancer. Int J Markers 1999; 14: 49-51.
23. Walther EK, Dahlmann N, Gorgulla HT. Tumor markers in the diagnosis and follow-up of head and neck cancer: role of CEA, CA19-9, SCC, TK, and dTTPase. Head Neck 1993; 15: 230-5.
24. Hallek M, Touitou Y, Levi F, et al. Serum thymidine kinase levels are elevated and exhibit diurnal variations in patients with advanced ovarian cancer. Clin Chem Acta 1997; 267: 155-66.
25. He Q, Skog S, Wang N, et al. Characterization of a peptide antibody against a C-terminal part of human and mouse cytosolic thymidine kinase, which is a marker for cell proliferation. Eur J Cell Biol 1996; 70: 11 7-24.
26. He Q, Skog S, Wu C, et al. Existence of phosphorylated and dephosphorylated forms of cytosolic thymidine kinase (TK1). BBA 1996; 1298: 25-30.
27. Skog S, He Q, Tribukait B. Lack of correlation between thymidine kinase activity and changes of DNA synthesis with tumour age: an in vivo study in Ehrlich ascites tumour. Cell Tissue Kinet 1990; 23: 603-17.
28. Pedersen C, Ingeberg S. Serum thymidine kinase in Aids patients treated with zidovudine (Letter). Lancet 1988; 22: 460-2.
29. Jacobsson B, Britton S, He Q, et al. Decreased thymidine kinase levels in peripheral blood cells from HIV-seropositive individuals: Implication for zidovudine metabolism. Aids Res Human Retroviruses 1995; 11: 805-11.
30. Bronzert DA, Monaco ME, Pinkus L, et al. Purification and properties of estrogen-responsive cytoplasmic thymidine from human breast cancer. Cancer Res 1981; 41: 604-10.
31. Karlström A, Neumuller M, Gronowitz SJ, et al. Molecular forms in human serum of enzymes synthesizing DNA-precursors and DNA. Mol Cell Biochem 1990; 92: 23-5.
32. Gröbner P, Mohberg J. Thymidine kinase enzyme variants in the life cycle of Physarum polycephalum. Exp Cell Res 1980; 126: 137-42.
33. Chang ZF, Huang DY, Husue NC. Differential phosphorylation of human thymidine kinase in proliferating and M phase-arrested human cells. J Biol Chem 1994; 33: 21249-54.