Combined segregation and linkage analysis of 59 Hodgkin's disease families indicates the role of HLA determinants

European Journal of Human Genetics

Volumn 8, Issue 6, 2000, Pages 460-463

  Shugart, Yin Yao ^a,b   Collins, Andrew ^c  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

Author keywords

EBV; HLA; Hodgkin's disease; Linkage; Sib pairs

Indexed keywords

ARTICLE; ENVIRONMENTAL FACTOR; FAMILIAL CANCER; FEMALE; GENE SEGREGATION; GENETIC LINKAGE; HAPLOTYPE; HLA SYSTEM; HODGKIN DISEASE; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL;

HAPLOTYPES; HLA ANTIGENS; HODGKIN DISEASE; HUMANS; LIKELIHOOD FUNCTIONS; LINKAGE DISEQUILIBRIUM; NUCLEAR FAMILY;

EID: 0034123514     PISSN: 10184813     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.ejhg.5200419     Document Type: Article

References (20)

1. Mueller NE: Hodgkin's disease. In: Scottenfeld D, Fraumeni JF Jr. Cancer Epidemiology and Prevention. 2nd edn. Oxford University Press: New York, 1996.
2. Razis DV, Dimond HD, Craver LF: Familial Hodgkin's disease: its significance and implications. Ann Intern Mad 1959; 51: 933-971.
3. Grufferman S et al: Hodgkin's disease in siblings. N Engl J Med 1977; 296: 248-253.
4. Robertson SJ, Lowman JT, Grufferman S et al: Familial Hodgkin's disease, a clinical and laboratory investigation. Cancer 1987; 59: 1314-1319.
5. Mack et al: Concordance for Hodgkin's disease in identical twins suggesting genetic susceptibility to the young-adult form of the disease. N Engl J Med 1995; 16: 332; 413-418.
6. Hors J, Dausset J: HLA and susceptibiity to Hodgkin's disease. Immunol Rev 1983; 70: 167-192.
7. Risch N: Assessing the role of HLA-linked and unlinked determinants of disease. Am J Hum Genet 1987; 40: 1-14
8. Morton NE: Logarithm of odds (lods) for linkage in complex inheritance. Proc Natl Acad Sci USA 1996; 93: 3471-3476.
9. Conte R, Laria F, Zucchelli: HLA in familial Hodgkin's disease. J Immunogenet 1983; 10: 251-255.
10. Hafez M, El-Tahau H, El-Moris Z et al: Genetic susceptibility in Hodgkin's lymphoma. In: Muller JH, Weber W (eds). Familial Cancer. Karger: Basel, 1985; pp 175-179.
11. Lynch HT, Saldivar VA, Guirgis HA et al: Familial Hodgkin's disease and associated cancer, a clinical-pathologic study. Cancer 1976; 38: 2033-2041.
12. Kalidi I, Masset M, Gony J et al: MHC related genetic susceptibility to Hodgkin's disease. Hématologie 1989; 31: 149-152.
13. Morton NE, Shields DC, Collins A: Genetic epidemiology of complex phenotypes. Ann Hum Genet 1991; 55: 301-314.
14. Clerget-Darpoux F, Bonaiti-Pellie C, Hochez J: Effects of misspecifying genetic parameters in lod score analysis. Biometrics 1986; 42: 393-399.
15. Holmans P: Asymptotic properties of affected sib-pair linkage analysis. Am J Hum Genet 1993; 52: 362-374.
16. Harris EI, Bale SJ, Tucker MA, Greene MH: Complex segregation analysis of multiple case Hodgkin's disease families. Am J Hum Genet 1985; 37: A197.
17. Morton NE: Sequential tests for the detection of linkage. Am J Hum Genet 1955; 7: 277-318.
18. Ott J: Analysis of Human Genetic Linkage (rev. edn) Johns Hopkins University Press: Baltimore and London, 1991.
19. Lio P, Morton NE: Comparison of parametric and nonparametric methods to map oligogenes by linkage. Proc Natl Acad Sci USA 1997; 94: 5344-5348.
20. Davies JL, Kawaguchi Y, Bennet JT et al: A genome-wide search for human type I diabetes susceptibility genes. Nature 1994; 371: 130-135.