Functional analyses of the EBNA1 origin DNA binding protein of Epstein- Barr virus

Journal of Virology

Volumn 74, Issue 11, 2000, Pages 4939-4948

  Ceccarelli, Derek F J ^a   Frappier, Lori ^b  

^a MCMASTER UNIVERSITY   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

DNA BINDING PROTEIN; EPSTEIN BARR VIRUS ANTIGEN; VIRUS PROTEIN;

ARTICLE; DIMERIZATION; DNA REPLICATION ORIGIN; DNA SEQUENCE; EPISOME; EPSTEIN BARR VIRUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DNA BINDING; PROTEIN DOMAIN; TRANSACTIVATION; VIRUS LATENCY;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; DNA, VIRAL; EPSTEIN-BARR VIRUS NUCLEAR ANTIGENS; HERPESVIRUS 4, HUMAN; HUMANS; MOLECULAR SEQUENCE DATA; PROLINE; REPLICATION ORIGIN;

EID: 0034122511     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.74.11.4939-4948.2000     Document Type: Article

References (53)

1. Adams, A. 1987. Replication of latent Epstein-Barr virus genomes. J. Virol. 61:1743-1746.
2. Ambinder, R. F., M. Mullen, Y. Chang, G. S. Hayward, and S. D. Hayward. 1991. Functional domains of Epstein-Barr nuclear antigen EBNA-1. J. Virol. 65:1466-1478.
3. Ambinder, R. F., W. A. Shah, D. R. Rawlins, G. S. Hayward, and S. D. Hayward. 1990. Definition of the sequence requirements for binding of the EBNA-1 protein to its palindromic target sites in Epstein-Barr virus DNA. J. Virol. 64:2369-2379.
4. Ausubel, F. M., R. Brent, R. E. Kingston, D. D. Moore, J. G. Seidman, J. A. Smith, and K. Struhl. 1991. Current protocols in molecular biology, vol. 1. John Wiley and Sons, New York, N.Y.
5. Avolio-Hunter, T. M., and L. Frappier. 1998. Mechanistic studies on the DNA linking activity of the Epstein-Barr nuclear antigen 1. Nucleic Acids Res. 26:4462-1470.
6. Barwell, J., A. Bochkarev, R. Pfuetzner, H. Tong, D. Yang, L. Frappier, and A. Edwards. 1995. Purification and crystallization of the DNA-binding and dimerization domain of the Epstein-Barr virus nuclear antigen 1. J. Biol. Chem. 270:20556-20559.
7. Blake, N., S. Lee, I. Redchenko, W. Thomas, N. Steven, A. Leese, P. Steigerwald-Mullen, M. G. Kurilla, L. Frappier, and A. Rickinson. 1997. Human CDS+ T cell responses to EBV EBNA1: HLA class I presentation of the (GLY-ALA) containing protein requires exogenous processing. Immunity 7:791-802.
8. Bochkarev, A., J. Barwell, R. Pfuetzner, E. Bochkareva, L. Frappier, and A. M. Edwards. 1996. Crystal structure of the DNA-binding domain of the Epstein-Barr virus origin binding protein. EBNA1, bound to DNA. Cell 84:791-800.
9. Bochkarev, A., J. Barwell, R. Pfuetzner, W. Furey, A. Edwards, and L. Frappier. 1995. Crystal structure of the DNA binding domain of the Epstein-Barr virus origin binding protein EBNA1. Cell 83:39-46.
10. Chen, M.-R., J. M. Middeldorp, and S. D. Hayward. 1993. Separation of the complex DNA binding domain of EBNA-1 into DNA recognition and dimerization subdomains of novel structure. J. Virol. 67:4875-4885.
11. Delecluse, H.-J., S. Bartnizke, W. Hammerschmidt, J. Bullerdiek, and G. W. Bornkamm. 1993. Episomal and integrated copies of Epstein-Barr virus coexist in Burkitt's lymphoma cell lines. J. Virol. 67:1292-1299.
12. Fischer, N., E. Kremmer, G. Lautscham, N. Mueller-Lantzsch, and F. A. Grasser. 1997. Epstein-Barr virus nuclear antigen 1 forms a complex with the nuclear transporter karyopherin α2. J. Biol. Chem. 272:3999-4005.
13. Frappier, L., and M. O'Donnell. 1991. Overproduction, purification and characterization of EBNA1, the origin binding protein of Epstein-Barr virus. J. Biol. Chem. 266:7819-7826.
14. Gahn, T., and B. Sugden. 1995. An EBNA1-dependent enhancer acts from a distance of 10 kilobase pairs to increase expression of the Epstein-Barr virus LMP gene. J. Virol. 69:2633-2636.
15. Gahn, T. A., and C. L. Schildkraut. 1989. The Epstein-Barr virus origin of plasmid replication, oriP, contains both the initiation and termination sites of DNA replication. Cell 58:527-535.
16. Goldsmith, K., L. Bendell, and L. Frappier. 1993. Identification of EBNA1 amino acid sequences required for the interaction of the functional elements of the Epstein-Barr virus latent origin of DNA replication. J. Virol. 67:3418-3426.
17. Graham, F. L., and A. J. van der Eb. 1973. A new technique for the assay of infectivity of human adenovirus 5 DNA. Virology 5:456-467.
18. Harris, A., B. D. Young, and B. E. Griffin. 1985. Random association of Epstein-Barr virus genomes with host cell metaphase chromosomes in Burkitt's lymphoma-derived cell lines. J. Virol. 56:328-332.
19. Harrison, S., K. Fisenne, and J. Hearing. 1994. Sequence requirements of the Epstein-Barr virus latent origin of DNA replication. J. Virol. 68:1913-1925.
20. Hegde, R. S., S. R. Grossman, L. A. Laimins, and P. B. Sigler. 1992. Crystal structure at 1.7Å of the bovine papillomavirus-1 E2 DNA-binding protein bound to its DNA target. Nature 359:505-512.
21. Hirt, B. 1967. Selective extraction of polyoma DNA from infected mouse cell culture. J. Mol. Biol. 26:365-369.
22. Kim, A. L., M. Maher, J. B. Hayman, J. Ozer, D. Zerby, J. L. Yates, and P. M. Lieberman. 1997. An imperfect correlation between DNA replication activity of Epstein-Barr virus nuclear antigen 1 (EBNA1) and binding to the nuclear import receptor. Rch1/importin α. Virology 239:340-351.
23. Kirchmaier, A. L., and B. Sugden, 1997. Dominant-negative inhibitors of EBNA1 of Epstein-Barr virus. J. Virol. 71:1766-1775.
24. Laine, A., and L. Frappier. 1995. Identification of Epstein-Barr nuclear antigen 1 protein domains that direct interactions at a distance between DNA-bound proteins. J. Biol. Chem. 270:30914-30918.
25. Langle-Rouault, F., V. Patzel, A. Benavente, M. Taillez, N. Silvestre, A. Bompard, G. Sczakiel, E. Jacobs, and K. Rittner. 1998. Up to 100-fold increase of apparent gene expression in the presence of Epstein-Barr virus oriP sequences and EBNA1: implications of the nuclear import of plasmids. J. Virol. 72:6181-6185.
26. Levitskaya, J., M. Coram, V. Levitsky, S. Imreh, P. Steigerwald-Mullen, G. Klein, M. G. Kurilla, and M. G. Masucci. 1995. Inhibition of antigen processing by the internal repeat region of the Epstein-Barr virus nuclear antigen-1. Nature 375:685-688.
27. Lupton, S., and A. J. Levine. 1985. Mapping of genetic elements of Epstein-Barr virus that facilitate extrachromosomal persistence of Epstein-Barr virus-derived plasmids in human cells. Mol. Cell. Biol. 5:2533-2542.
28. Mackey, D., T. Middleton, and B. Sugden. 1995. Multiple regions within EBNA1 can link DNAs. J. Virol. 69:6199-6208.
29. Mackey, D., and B. Sugden. 1999. The linking regions of EBNA1 are essential for its support of replication and transcription. Mol. Cell. Biol. 19:3349-3359.
30. Mackey, D., and B. Sugden. 1997. Studies on the mechanism of DNA linking by Epstein-Barr virus nuclear antigen 1. J. Biol. Chem. 272:29873-29879.
31. Marechal, V., A. Dehee, R. Chikhi-Brachet, T. Piolot, M. Coppey-Moisan, and J. Nicolas. 1999. Mapping EBNA1 domains involved in binding to metaphase chromosomes. J. Virol. 73:4385-4392.
32. Middleton, T., and B. Sugden. 1992. EBNA1 can link the enhancer element to the initiator element of the Epstein-Barr virus plasmid origin of DNA replication. J. Virol. 66:489-495.
33. Niller, H. H., G. Glaser, R. Knuchel, and H. Wolf. 1995. Nucleoprotein complexes and DNA 5′-ends at oriP of Epstein-Barr virus. J. Biol. Chem. 270:12864-12858.
34. Nonkwelo, C., J. Skinner, A. Bell, A. Rickinson, and J. Sample. 1996. Transcription start site downstream of the Epstein-Barr virus (EBV) Fp promoter in early-passage Burkitt lymphoma cells define a fourth promoter for expression of the EBV EBNA1 protein. J. Virol. 70:623-627.
35. Petti, L., C. Sample, and E. Kieff. 1990. Subnuclear localization and phosphorylation of Epstein-Barr virus latent infection nuclear proteins. Virology 176:563-574.
36. Polvino-Bodnar, M., and P. A. Schaffer. 1992. DNA binding activity is required for EBNA1-dependent transcriptional activation and DNA replication. Virology 187:591-603.
37. Rawlins, D. R., G. Milman, S. D. Hayward, and G. S. Hayward. 1985. Sequence-specific DNA binding of the Epstein-Barr virus nuclear antigen (EBNA1) to clustered sites in the plasmid maintenance region. Cell 42:859-868.
38. Reisman, D., and B. Sugden. 1986. trans activation of an Epstein-Barr viral transcriptional enhancer by the Epstein-Barr viral nuclear antigen 1. Mol. Cell. Biol. 6:3838-3846.
39. Reisman, D., J. Yates, and B. Sugden. 1985. A putative origin of replication of plasmids derived from Epstein-Barr virus is composed of two cis-acting components. Mol. Cell. Biol. 5:1822-1832.
40. Rickinson, A. B., and E. Kieff. 1996. Epstein-Barr virus, p. 2397-2446. In B. N. Fields, D. M. Knipe, and P. M. Howley (ed.), Fields virology, 3rd ed. Lippincott-Raven Publishers, Philadelphia, Pa.
41. Sample, J., E. B. D. Henson, and C. Sample. 1992. The Epstein-Barr virus nuclear protein 1 promoter active in type I latency is autoregulated. J. Virol. 66:465-4661.
42. Shire, K., D. F. J. Ceccarelli, T. M. Avolio-Hunter, and L. Frappier. 1999. EBP2, a human protein that interacts with sequences of the Epstein-Barr nuclear antigen 1 important for plasmid maintenance. J. Virol. 73:2587-2595.
43. Snudden, D. K., J. Hearing, P. R. Smith, F. A. Grasser, and B. E. Griffin. 1994. EBNA1, the major nuclear antigen of Epstein-Barr virus, resembles 'RGG' RNA binding proteins. EMBO J. 13:4840-4847.
44. Studier, F. W., A. H. Rosenberg, J. J. Dunn, and J. W. Dubendorff. 1990. Use of T7 RNA polymerase to direct expression of cloned genes. Methods Enzymol. 185:60-89.
45. Sugden, B., and N. Warren. 1989. A promoter of Epstein-Barr virus that can function during latent infection can be transactivated by EBNA-1, a viral protein required for viral DNA replication during latent infection. J. Virol. 63:2644-2649.
46. Summers, H., J. A. Barwell, R. A. Pfuetzner, A. M. Edwards, and L. Frappier. 1996. Cooperative assembly of EBNA1 on the Epstein-Barr virus latent origin of replication. J. Virol. 70:1228-1231.
47. Summers, H., A. Fleming, and L. Frappier. 1997. Requirements for EBNA1-induced permanganate sensitivity of the Epstein-Barr virus latent origin of DNA replication. J. Biol. Chem. 272:26434-26440.
48. Wang, Y., J. E. Finan, J. M. Middeldorp, and S. D. Hayward. 1997. P32/TAP, a cellular protein that interacts with EBNA-1 of Epstein-Barr virus. Virology 236:18-29.
49. Wysokenski, D. A., and J. L. Yates. 1989. Multiple EBNA1-binding sites are required to form an EBNA1-dependent enhancer and to activate a minimal replicative origin within oriP of Epstein-Barr virus. J. Virol. 63:2657-2666.
50. Yates, J. L. 1996. Epstein-Barr virus DNA replication, p. 751-773. In M. DePamphilis (ed.). DNA replication in eukaryotic cells. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
51. Yates, J. L., and S. M. Camiolo. 1988. Dissection of DNA replication and enhancer activation functions of Epstein-Barr virus nuclear antigen 1. Cancer Cells 6:197-205.
52. Yates, J. L., and N. Guan. 1991. Epstein-Barr virus-derived plasmids replicate only once per cell cycle and are not amplified after entry into cells. J. Virol. 65:483-488.
53. Yates, J. L., N. Warren, and B. Sugden. 1985. Stable replication of plasmids derived from Epstein-Barr virus in various mammalian cells. Nature 313: 812-815.