Deficiency of natural anticoagulant proteins C, S, and antithrombin in portal vein thrombosis: A secondary phenomenon?

Gut

Volumn 46, Issue 4, 2000, Pages 534-539

  Fisher, N C ^a   Wilde, J T ^a   Roper, J ^a   Elias, E ^a  

^a QUEEN ELIZABETH HOSPITAL   (United Kingdom)

Author keywords

Antithrombin; Extrahepatic portal hypertension; Natural anticoagulant protein; Portal vein thrombosis; Protein C; Protein S

Indexed keywords

ANTICOAGULANT PROTEIN; ANTITHROMBIN; PROTEIN C; PROTEIN S;

ADOLESCENT; ADULT; ARTICLE; BLOOD CLOTTING; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; HUMAN; LIVER BLOOD FLOW; PARTIAL THROMBOPLASTIN TIME; PORTAL HYPERTENSION; PORTAL VEIN THROMBOSIS; PORTOSYSTEMIC ANASTOMOSIS; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTHROMBIN TIME;

ADULT; AGED; ANTITHROMBINS; COAGULATION PROTEIN DISORDERS; FEMALE; HUMANS; MALE; MIDDLE AGED; PORTAL VEIN; PROTEIN C DEFICIENCY; PROTEIN S DEFICIENCY; VENOUS THROMBOSIS;

EID: 0034122438     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.46.4.534     Document Type: Article

References (18)

1. 1 Valla D, Denninger M, Delvigne J, et al. Portal vein thrombosis with ruptured oesophageal varices as presenting manifestation of hereditary protein C deficiency. Gut 1988;29:856-9.
2. 2 Valla D, Casedevall N, Huisse MG, et al. Etiology of portal vein thrombosis in adults. Gastroenterology 1988;94:10639.
3. 3 Levoir D, Emmerich J, Alhenc-Gelas M, et al. Portal vein thrombosis and factor V Arg 506 to G1n mutation. Thromb Haemost 1995;73:550-1.
4. 4 Valla D, Chait Y, Denninger MH, et al. Portal and hepatic vein thromboses: concurrence of multiple prothrombotic states and focal factors. Hepatology 1997;26:203A.
5. 5 Chamouard P, Pencreach E, Maloisel F, et al. Frequent factor II G20210A mutation in idiopathic portal vein thrombosis. Gastroenterology 1990;116:144-8.
6. 6 Robson SC, Kahn D, Kruskal J, et al. Disorded hemostasis in extrahepatic portal hypertension. Hepatolagy 1993;18: 853-7.
7. 7 Dubuisson C, Boyer-Neumann C, Wolf M, et al. Protein C, protein S and antithrombin III in children with portal vein obstruction. J Hepatol 1997;27:132-5.
8. 8 Willner IR, Waters B, Payton JD, et al. Hepatoportal sclerosis: clinical features and association with hypercoagulable states. Hepatology 1997;26:204A.
9. 9 Hillaire S, Degott C, Lebrec D, et al. Idiopathic noncirrhotic intrahepatic portal hypertension: a re-evaluation of aetiology and outcome. Hepatology 1997;26:207A.
10. 10 Lane DA, Mannucci PM, Bauer KA, et al. Inherited thrombophilia: part 2 (review article). Thromb Haemost 1996;76:824-34.
11. 11 Aiach M, Borgel D, Gaussem P, et al. Protein C and S deficiencies (review article). Sem Haematol 1997;34:205-16.
12. 12 Tran S, Yeo E, Heathcote EJ. Coagulation profile in non-cirrhotic portal vein thrombosis: evidence for ongoing thrombin generation. Hepatology 1997;26:395A.
13. 13 Robson SC, Jaskiewicz K, Engelbrecht G, et al. Haemostatic and immunological sequelae of portacaval shunt in rats. Liver 1995;15:293-9.
14. 14 Jamieson CS, McDowell SA, Marlar RA, et al. Developmental expression of protein C and protein S in the rat. Thromb Res 1995;78:407-19.
15. 15 Tanabe S, Sugo T, Matsuda M. Synthesis of protein C in human umbilical vein endothelial cells. J Biochem 1991; 109:924-8.
16. 16 Orloff MH, Orloff MS, Rambotti M. Treatment of bleeding oesophageal varices due to extrahepatic portal hypertension: results of portal-systemic shunting during 35 years. J Paed Surg 1994;29:142-51.
17. 17 Khan D, Krige E, Terblanche J, et al. A 15-year experience of injection sclerotherapy in adult patients with extrahepatic portal venous obstruction. Ann Surg 1994;219:34-9.
18. 18 Condat B, Pessione F, Erlinger S, Valla D. Portal vein thrombosis: outcome in 94 adult patients [abstract]. Hepatology 1997;26:204A.