Changes in benzodiazepine binding in a subkindling situation

Epilepsia

Volumn 41, Issue 6, 2000, Pages 651-654

  Rössler, Anne Sophie ^a,d   Launay, Jean Marie ^b   Venault, Patrice ^a   Dodd, Robert H ^c   Chapouthier, Georges ^a  

^a CNRS UMR 7593 Vulnerabilite Adaptation et Psychopathologie   (France)

^b HÔPITAL LARIBOISIÈRE   (France)

^c CNRS   (France)

^d PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

Author keywords

Benzodiazepine receptors; Carbolines; Convulsions; GABA inhibition; Kindling;

Indexed keywords

4 AMINOBUTYRIC ACID; BENZODIAZEPINE; BENZODIAZEPINE RECEPTOR STIMULATING AGENT; BETA CARBOLINE 3 CARBOXYLIC ACID METHYL ESTER; FLUMAZENIL;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG RECEPTOR BINDING; GABAERGIC SYSTEM; KINDLING; MOUSE; NONHUMAN; PRIORITY JOURNAL; TONIC CLONIC SEIZURE;

EID: 0034121128     PISSN: 00139580     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1528-1157.2000.tb00224.x     Document Type: Article

References (15)

1. Goddard GV. Development of epileptic seizures through brain stimulation at low intensity. Nature 1967;214:1020-1.
2. Sacks J, Glaser NM. Changes in susceptibility to the convulsant action of metrazol. J Pharmacol 1941;73:289-95.
3. Pinel JPJ, Cheung KF. Controlled demonstration of metrazol kindling. Pharmacol Biochem Behav 1977;6:599-600.
4. Little HJ, Nutt DJ. Chronic effects of benzodiazepine receptor ligand FG 7142: proconvulsant properties. Br J Pharmacol 1984; 83:951-8.
5. Gean PW, Shinnick-Gallagher P, Anderson AC. Spontaneous epileptiform activity and alteration of GABA- and of NMDA-mediated neurotransmission in amygdala neurons kindled in vivo. Brain Res 1989;494:177-81.
6. Kalichman MW, Mcintire Burnham W, Livingston KE. Pharmacological investigation of gamma-aminobutyric acid (GABA) and fully-developed generalized seizures in the amygdala-kindled rat. Neuropharmacology 1982;21:127-33.
7. Little JH, Nutt DJ, Taylor SC. Selective changes in the in vivo effects of benzodiazepine receptor ligands after chemical kindling with FG 7142. Neuropharmacology 1987;6:25-31.
8. 3H-RO5-4864 to crude homogenates of amygdala kindled rat brain: two months post-seizure. Brain Res 1983;279:259-62.
9. Chapouthier G, Martin B. β-Carbolines: from memory towards genetics. Eur Bull Cognit Psychol 1992;12:423-58.
10. Prado De Carvalho L, Grecksch G, Cavalheiro EA, Dodd RH, Chapouthier G, Rossier J. Characterization of convulsions induced by methyl β-carboline-3-carboxylate in mice. Eur J Pharmacol 1984;103:287-93.
11. Marley RJ, Wehner JM. Correlation between the enhancement of flunitrazepam binding by GABA and seizure susceptibility in mice. Life Sci 1987;40:2215-24.
12. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Ann Biochem 1976;72:248-54.
13. Marley RJ, Stincomb A, Wehner JM. Further characterization of benzodiazepine receptor differences in long-sleep and short-sleep in mice. Life Sci 1988;43:1223-31.
14. Chapouthier G, Bondoux D, Martin B, Desforges C, Launay JM. Genetic difference in sensitivity to β-carboline: evidence for the involvement of benzodiazepine receptors. Brain Res 1991;553: 342-46.
15. Rocha L, Ackermann RF, Engel J. Chronic and single administration of pentylenetetrazol modifies benzodiazepines receptor-binding: an autoradiographic study. Epilepsy Res 1996;24:65-72.