A deletion in the gI and gE genes of equine herpesvirus type 4 reduces viral virulence in the natural host and affects virus transmission during cell-to-cell spread

Virus Research

Volumn 67, Issue 2, 2000, Pages 189-202

  Damiani, Armando Mario ^a   Matsumura, Tomio ^b   Yokoyama, Naoaki ^c   Mikami, Takeshi ^d   Takahashi, Eiji ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b EQUINE RESEARCH INSTITUTE   (Japan)

^c AICHI CANCER CENTER HOSPITAL   (Japan)

^d OBIHIRO UNIVERSITY OF AGRICULTURE AND VETERINARY MEDICINE   (Japan)

Author keywords

EHV 4; Equine herpesvirus type 4; gE; gI

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; EQUINE HERPES VIRUS; GENE DELETION; HORSE; IN VIVO STUDY; INFECTION; KIDNEY CELL CULTURE; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; VIRUS REPLICATION; VIRUS TRANSMISSION; VIRUS VIRULENCE;

ANIMALS; ANTIBODIES, VIRAL; BLOTTING, SOUTHERN; CERCOPITHECUS AETHIOPS; DNA, VIRAL; GENE DELETION; GENES, VIRAL; HERPESVIRIDAE INFECTIONS; HORSE DISEASES; HORSES; PLAQUE ASSAY; RECOMBINANT PROTEINS; TRANSFECTION; VARICELLOVIRUS; VERO CELLS; VIRAL ENVELOPE PROTEINS; VIRULENCE;

EQUIDAE; EQUINE HERPESVIRUS 1; EQUINE HERPESVIRUS 4; HERPESVIRIDAE;

EID: 0034120956     PISSN: 01681702     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-1702(00)00146-5     Document Type: Article

References (43)

1. Balan P., Davis-Poynter N., Bell S., Atkinson H., Browne H., Minson T. An analysis of the in vitro and in vivo phenotypes of mutant herpes simplex virus type 1 lacking glycoproteins gG, gE, gI or the putative gJ. J. Gen. Virol. 75:1994;1245-1258.
2. Borchers K., Wolfinger U., Lawrenz B., Schellenbach A., Ludwig H. Equine herpesvirus 4 DNA in trigeminal ganglia of naturally infected horses detected by direct in situ PCR. J. Gen. Virol. 78:1997;1109-1114.
3. Browning G.F., Bulach D.M., Ficorilli M., Roy E.A., Thorp B.A., Studdert M.J. Latency of equine herpesvirus-4 (equine rhinopneumonitis virus). Vet. Rec. 123:1988;518-519.
4. Bürki F., Rossmanith W., Nowotny N., Pallan C., Möstl K., Lussy H. Viraemia and abortions are not prevented by two commercials equine herpesvirus-1 vaccines after experimental challenge of horses. Vet. Q. 12:1990;80-86.
5. Card J.P., Whealy M.E., Robbins A.K., Enquist L.W. Pseudorabies virus envelope glycoprotein gI influences both neurotropism and virulence during infection of the rat visual system. J. Virol. 66:1992;3032-3041.
6. Coignoul F.L., Bertram T.A., Cheville N.F. Pathogenicity of equine herpesvirus 1 subtype 2 for foals and adult pony mares. Vet. Microbiol. 9:1984;533-542.
7. Crabb B.S., Studdert M.J. Equine herpesvirus 4 (equine rhinopneumonitis virus) and 1 (equine abortion virus). Adv. Virus Res. 45:1995;153-190.
8. Damiani A.M., Matsumura T., Yokoyama N., Maeda K., Miyazawa T., Kai C., Mikami T. Nucleotide sequences of glycoprotein I and E genes of equine herpesvirus type 4. J. Vet. Med. Sci. 60(2):1998;219-225.
9. Damiani A.M., Jang H.-K., Matsumura T., Yokoyama N., Miyazawa T., Mikami T. Transcriptional analyses of the region of the equine herpesvirus type 4 genome encoding glycoproteins I and E. Arch. Virol. 144:1999;613-620.
10. Damiani A.M., Matsumura T., Jang H.-K., Izumiya Y., Mikami T., Takahashi E. Identification of the products of the equine herpesvirus type 4 gI and gE genes. J. Virol. 145:2000;1-8.
11. Dingwell K.S., Brunetti C.R., Hendricks R.L., Tang Q., Tang M., Rainbow A.J., Johnson D.C. Herpes simplex virus glycoproteins E and I facilitate cell-to-cell spread in vivo and across junctions of cultured cells. J. Virol. 68:1994;834-845.
12. Dingwell K.S., Doering L.C., Johnson D.C. Glycoproteins E and I facilitate neuron-to-neuron spread of herpes simplex type 1 virus. J. Virol. 69:1995;7087-7098.
13. Edington N., Welch H.M., Griffiths L. The prevalence of latent equid herpesviruses in the tissues of 40 abattoir horses. Equine Vet. J. 26(2):1994;140-142.
14. Enquist L.W., Dubin J., Whealy M.E., Card J.P. Complementation analysis of pseudorabies virus gE and gI mutants in retinal ganglion cell neurotropism. J. Virol. 69:1994;5275-5279.
15. Kaashoek M.J., Moerman A., Madic J., Weerdmeester K., Maris-Veldhuis M., Rijsewijk F.A.M., van Oirschot J.T. An inactivated vaccine based on a glycoprotein E-negative strain of bovine herpesvirus 1 induces protective immunity and allows serological differentation. Vaccine. 13(4):1995;342-346.
16. Kaashoek M.J., Rijsewicjk F.A.M., Ruuls R.C., Keil G.M., Thiry E., Pastoret P.P., van Oirschot J.T. Virulence, immunogenicity and reactivation of bovine herpesvirus 1 mutants with a deletion in the gC, gG, gI, gE, or in both the gI and gE gene. Vaccine. 16(8):1998;802-809.
17. Kawakami Y., Kaji T., Ishizaki R., Shimizu T., Matumoto M. Etiologic study on an outbreak of acute respiratory disease among colts due to equine rhinopneumonitis virus. Jpn. J. Exp. Med. 32:1962;211-229.
18. Kritas S.K., Pensaert M.B., Mettenleiter T.C. Invasion and spread of single glycoprotein deletion mutants of Aujeszky's disease virus (ADV) in the trigeminal nervous pathway of pigs after intranasal inoculation. Vet. Microbiol. 40:1994;323-334.
19. Kritas S.K., Pensaert M.B., Mettenleiter T.C. Role of envelope glycoproteins gI, gp63 and gIII in the invasion and spread of Aujeszky's disease virus in the olfactory nervous pathway of the pig. J. Gen. Virol. 75:1994;2319-2327.
20. - deletion mutant in the natural host. Virology. 220:1996;299-308.
21. Matsumura T., Sugiura T., Imagawa H., Fukunaga Y., Kamada M. Epizootiological aspects of the type 1 and type 4 equine herpesvirus infections among horse populations. J. Vet. Med. Sci. 54:1992;207-211.
22. Matsumura T., O'Callaghan D.J., Kondo T., Kamada M. Lack of virulence of the murine fibroblast adapted strain, Kentucky A (KyA), of equine herpesvirus type 1 (EHV-1) in young horses. Vet. Microbiol. 48:1996;353-365.
23. Matsumura T., Kondo T., Sugita S., Damiani A.M., O'Callaghan D.J., Imagawa H. An equine herpesvirus type 1 recombinant with a deletion in the gE and gI genes is avirulent in young horses. Virology. 242:1998;68-79.
24. Mettenleiter T.C., Zsak L., Kaplan A.S., Ben-Porat T., Lomniczi B. Role of the a structural glycoprotein of pseudorabies in virus virulence. J. Virol. 61:1987;4030-4032.
25. Mulder W.A., Jacobs L., Priem J., Kok G.L., Wagenaar F., Kimman T.G., Pol J.M. Glycoprotein gE-negative pseudorabies virus has a reduced capability to infect second-and-third-order neurons of the olfactory and trigeminal routes in the porcine central nervous system. J. Gen. Virol. 75:1994;3095-3106.
26. Mumford J.A., Bates J. Trials of an inactivated equid herpesvirus 1 vaccine: challenge with a subtype 2 virus. Vet. Rec. 114:1984;375-381.
27. Nagesha H.S., McNeil J.R., Ficorilli N., Studdert M. Cloning and restriction endonuclease mapping of the genome of an equine herpesvirus 4 (equine rhinopneumonitis virus) strain 405/76. Arch. Virol. 124:1992;379-387.
28. Neidhardt H., Schröder C.H., Kaerner H.C. Herpes simplex virus type 1 glycoprotein E is not indispensable for viral infectivity. J. Virol. 61:1987;600-603.
29. Nishikawa Y., Xuan X., Otsuka H. Identification and characterization of the glycoproteins E and I genes of canine herpesvirus. Virus Res. 56:1998;77-92.
30. Ostlund E.N. The equine herpesvirus. Vet. Clin. North Am. 9:1993;283-294.
31. Rebordosa X., Piñol J., Pérez-Pons J.A., Lloberas J., Naval J., Serra-Hartmann X., Espuña E., Querol E. Glycoprotein E of bovine herpesvirus type 1 is involved in virus transmission by direct cell-to-cell spread. Virus Res. 45:1996;59-68.
32. Rigby P.W., Dieckmann M., Rhodes C., Berg P. Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I. J. Mol. Virol. 113:1977;237-251.
33. Roizman B., Sears A.E. Herpes simplex virus and their replication. Fields B.N., Knipe D.M., Chanock R.M., Howley P.M., Melnick J.L., Monath T.P., Roizman B., Straus S.E. Fundamental Virology. 3rd ed. 1995;1043-1107 Lippincott-Raven, New York.
34. Roizman, B., Desrosiers, R.C., Fleckenstein, B., Lopez, C., Minson, A.C., Studdert, M.J., 1995. Herpesviridae. In: Murphy, F.A., Fauquet, C.M., Bishop, D.H.L., Ghabrial, S.A., Jarvis, A.W., Martelli, G.P., Mayo, M.A., Summers, M.D. (Eds.), The Classification and Nomenclature of Viruses. Sixth Report of the International Committee on Taxonomy of Viruses. Springier, Wien, pp. 114-127 (Arch. Virol. (Suppl.) 10).
35. Roizman, B., Desrosiers, R.C., Fleckenstein, B., Lopez, C., Minson, A.C., Studdert, M.J., 1995. Herpesviridae. In: Murphy, F.A., Fauquet, C.M., Bishop, D.H.L., Ghabrial, S.A., Jarvis, A.W., Martelli, G.P., Mayo, M.A., Summers, M.D. (Eds.), The Classification and Nomenclature of Viruses. Sixth Report of the International Committee on Taxonomy of Viruses. Springier, Wien, pp. 114-127 (Arch. Virol. (Suppl.) 10).
36. Sambrook J., Fritsh E.F., Maniatis T. Molecular Cloning: A Laboratory Manual. 2nd ed. 1989;Cold Spring Harbor Laboratory, Cold Spring Harbor, NY.
37. Shimizu T., Kawakami Y., Kaji T., Ishizaki R., Sugimura K., Matumoto M. Experimental infection of colts with equine rhinopneumonitis virus. Natl. Inst. Anim. Health Q. (Jpn). 1:1961;119-125.
38. Sussman M.D., Maes R.K., Kruger J.M., Spatz S.J., Venta J. A feline herpesvirus-1 recombinant with a deletion in the genes for glycoproteins gI and gE is effective as a vaccine for feline rhinotracheitis. Virology. 214:1995;12-20.
39. Telford E.A.R., Watson M.S., Perry J., Cullinane A.A., Davison A.J. The DNA sequence of equine herpesvirus-4. J. Gen. Virol. 79:1998;1197-1203.
40. Tewari D., Gibson J.S., Slater J.D., O'Neill T., Hannant D., Allen G.P., Field H.J. Modulation of the serological response of specific pathogen-free (EHV-free) foals to EHV-1 by previous infection with EHV-4 or a TK-deletion mutant of EHV-1. Arch. Virol. 132:1993;101-120.
41. van Engelenburg F.A.C., Kaashoek M.J., Rijsewijk F.A.M., van den Burg L., Moerman A., Gielkens A.L.J., van Oirschot J.T. A glycoprotein E deletion mutant of bovine herpesvirus 1 is avirulent in calves. J. Gen. Virol. 75:1994;2311-2318.
42. van Oirschot J.T., Kaashoek M.J., Rijsewijk F.A., Stegeman J.A. The use of marker vaccines in eradication of herpesviruses. J. Biotechnol. 44:1996;75-81.
43. Welch H.M., Bridges C.G., Lyon A.M., Griffiths L., Edington N. Latent equid herpesvirus 1 and 4: detection and distinction using the polymerase chain reaction and co-cultivation from lymphoid tissues. J. Gen. Virol. 73:1992;261-268.