Iontophoresis-enhanced absorptive flux of polar molecules across intestinal tissue in vitro

Pharmaceutical Research

Volumn 17, Issue 4, 2000, Pages 476-478

  Leonard, Maurice ^a   Creed, Elizabeth ^a   Brayden, David ^a   Baird, Alan W ^b  

^a ELAN PHARMACEUTICALS   (United States)

^b UNIVERSITY COLLEGE DUBLIN   (Ireland)

Author keywords

Convective solvent flow; Electro osmosis; Iontophoresis; Mannitol; Permeability co efficient; Thyrotrophin releasing hormone

Indexed keywords

CARBON 14; FORSKOLIN; GLUCOSE; MANNITOL; PROTIRELIN; TRITIUM;

ACTIVE TRANSPORT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIFFUSION; DRUG ABSORPTION; DRUG DELIVERY SYSTEM; ELECTRIC RESISTANCE; HYDROPHILICITY; IN VITRO STUDY; INTESTINE ABSORPTION; INTESTINE EPITHELIUM; IONTOPHORESIS; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SHORT CIRCUIT CURRENT; TRANSCYTOSIS;

ANIMALS; INTESTINES; IONTOPHORESIS; MALE; PHARMACOKINETICS; RATS; RATS, WISTAR;

EID: 0034120217     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1007541423500     Document Type: Article

References (15)

1. 1. J. C. Keister and G. B. Kasting. Ionic mass transport through a homogeneous membrane in the presence of a uniform electric field. J. Membr. Sci. 29:155-167 (1986).
2. 2. N. H. Bellantone, S. Rim, M. L. Francoeur, and B. Rasadi. Enhanced percutaneous absorption via iontophoresis. 1. Evaluation of an in vitro system and transport of model compounds. Int. J. Pharm. 30:63-72 (1986).
3. 3. D. M. Maurice. Iontophoresis of fluorescein into the posterior segment of the rabbit eye. Ophthalmology. 93:128-132 (1986).
4. 4. S. Leduc. Introduction of medicinal substances into the depth of tissues by electric current. Ann. d'Electrobiol. 3:545-560 (1900).
5. 5. P. L. Smith, D. A. Wall, C. H. Gochoco, and G. Wilson. Oral absorption of peptides and proteins. Adv. Drug Del. Rev. 8:253-290 (1992).
6. 6. T. Kararli. Gastrointestinal absorption of drugs. Crit. Rev. Ther. Drug Carrier Syst. 6:39-86 (1989).
7. 7. G. Grass and S. Sweetana. In vitro measurement of gastrointestinal tissue permeability using a new diffusion cell. Pharm. Res. 5:372-376 (1988).
8. 8. P. Artursson and J. Karlsson. Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells. Biochem. Biophys. Res. Commun. 175:880-5, (1991).
9. 9. M. Begona Delgado-Charro and R. H. Guy. Characterisation of convective solvent flow during iontophoresis. Pharm. Res. 11:929-935 (1994).
10. 10. S. M. Sims and W. I. Higuchi. Baseline studies on iontophoretic transport in hairless mouse skin: The effect of applied voltage drop and pH on the iontophoresis of a model weak electrolyte. J. Membr. Sci. 49:305-320 (1986).
11. 11. S. M. Sims, W. I. Higuchi, and V. Srinivasan. Skin alteration and convective solvent flow effects during iontophoresis. 1. Neutral solute transport across human skin. Int. J. Pharm. 69:109-121 (1991).
12. 12. R. R. Burnette and B. Ongpipattanakul. Characterisation of the permselective properties of excised human skin during iontophoresis. J. Pharm. Sci. 76:765-773 (1987).
13. 13. M. J. Pikal. The role of electrosmotic flow in transdermal iontophoresis. Adv. Drug Del. Rev. 9:201-237 (1992).
14. 14. J. L. Madara. Regulation of the movement of solutes across tight junctions. Anna. Rev. Physiol. 60:143-159 (1998).
15. 15. M. S. Balda, J. A. Whitney, C. Flores, S. Gonzalez., M. Cereijido, and K. Matter. Functional dissociation of paracellular permeability and transepithelial electrical resistance and disruption of the apical-basolateral intramembrane diffusion barrier by expression of a mutant tight junction membrane protein. J. Cell Biol. 134:1031-1049 (1996).