Training in hypoxia: Modulation of metabolic and cardiovascular risk factors in men

Medicine and Science in Sports and Exercise

Volumn 32, Issue 6, 2000, Pages 1058-1066

  Bailey, Damian M ^a   Davies, Bruce ^a   Baker, Julien ^a  

^a UNIVERSITY OF GLAMORGAN   (United Kingdom)

Author keywords

CARDIOVASCULAR DISEASE; EXERCISE; HYPOXIA; RISK FACTORS

Indexed keywords

ADULT; ARTICLE; CARDIOVASCULAR DISEASE; CORONARY RISK; EXERCISE; HEART PROTECTION; HUMAN; HYPOXIA; MALE; NORMAL HUMAN; RISK FACTOR;

EID: 0034120216     PISSN: 01959131     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005768-200006000-00004     Document Type: Article

References (39)

1. ALESHIN, I. A., A. N. TINKOV, Y. I. KOTS, and V. P. TVERDOKHLIB. Treatment of cardiovascular diseases by means of adaptation to periodic hypoxia in pressure chamber. Ter. Arkh. 69: 54-58, 1997.
2. AMERICAN COLLEGE OF SPORTS MEDICINE. ACSM's Guidelines for Exercise Testing and Prescription. 5th Ed. Philadelphia: Williams & Wilkins, 1995, pp. 20-48.
3. ASANO, K., R. S. MAZZEO, R. E. MCCULLOUGH, E. E. WOLFEL, and J. T. REEVES. Relation of sympathetic activation to ventilation in man at 4,300 m altitude. Aviation, Space Environ. Med. 68:104-110, 1997.
4. AVILA, M. A., M. V. CARRETERO, E. N. RODRIGUEZ, and J. M. MATO. Regulation by hypoxia of methionine adenosyltransferase activity and gene expression in rat hepatocytes. Gastroenterology 114: 364-371, 1998.
5. BAILEY, D. M., B. DAVIES, L. ROMER, L. CASTELL, E. NEWSHOLME, and G. GANDY. Implications of moderate altitude training for sea-level endurance in elite distance runners. Eur. J. Appl. Physiol. 78:360-368, 1998.
6. BAILEY, D. M., B. DAVIES, L. M. CASTELL, et al. Intermittent normobaric hypoxia; changes in plasma amino acids and implications for exercise performance (Abstract). J. Physiol. C17:52, 1998.
7. BIGARD, A., X. P. LAVIER, L. ULLMANN, H. LEGRAND, P. DOUCE, and C. Y. GUEZENNEC. Branched-chain amino acid supplementation during repeated prolonged skiing exercises at altitude. Int. J. Sports Nutr. 6:295-306, 1996.
8. BRONCHMANN-HANSEN, O. and K. MYHRE. Blood pressure, intraocular pressure, and retinal vessels after high altitude mountain exposure. Aviat. Space Environ. Med. 60:870-976, 1989.
9. CARTER, J. E. L. and B. H. HEATH. The Heath-Carter anthropometric somatotype. In: Somatotyping: Development and Applications, J. E. L. Carter and B. H. Heath (Eds.). Cambridge: Cambridge University Press, 1990, pp. 367-375.
10. CHENG, B., H. KUIPERS, A. C. SNYDER, H. A. KEIZER, A. JEUKENDRUP, and M. HESSELINK. A new approach for the determination of ventilatory and lactate thresholds. Int. J. Sports Med. 13:518-522, 1992.
11. 2. J. Appl. Physiol. 68:833-842, 1990.
12. DAVIES, B. W. D. ASHTON, D. J. ROWLANDS, et al. Association of conventional and exertional CHD risk factors in 5,000 apparently healthy men. Clin. Cardiol. 19:303-308, 1996.
13. DESPLANCHES, D., H. HOPPELER, M. T. LINOISSIER, et al. Effects of training in normoxia and normobaric hypoxia on human muscle ultrastructure. Eur. J. Appl. Physiol. 425:263-267, 1993.
14. DILL, D. B. and D. L. COSTILL. Calculation of percent changes in volumes of blood, plasma, and red cells in dehydration. J. Appl. Physiol. 37:247-248, 1974.
15. DURNIN, J. V. G. A. and J. WOMERSLEY. Body fat assessed from total body density and its estimation from skinfold thickness: measurements on 481 men and women aged from 16 to 72 years. Br. J. Nutr. 32:77-97, 1974.
16. FÉRÉZOU, J., J. P. RICHALET, and C. RATHAT. Changes in plasma lipids and lipoprotein cholesterol during a high altitude mountaineering expedition (4800 m). Eur. J. Appl. Physiol. 57:740-745, 1988.
17. FRIEDEWALD, W. T., I. Levy and D. S. FREDRICKSON. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without the use of the preparative centrifuge. Clin. Chem. 18:499-502, 1972.
18. HASKELL, W. L. Health consequences of physical activity: understanding and challenges regarding dose-response. Med. Sci. Sports Exert: 26:649-660, 1994.
19. HIETANEN, E. In: Regulation of Serum Lipids by Physical Exercise, E. Hietanen (Ed.). Boca Raton, FL: CRC Press, 1982, pp. 35-54.
20. HOGAN, M. C. and H. G. WELCH. The effect of altered arterial oxygen tensions on muscle metabolism in dog skeletal muscle during fatiguing work. Am. J. Physiol. 251:C216-C222, 1986.
21. JOINT NATIONAL COMMITTEE ON DETECTION, EVALUATION, AND TREATMENT OF HIGH BLOOD PRESSURE. The Sixth Report of the Joint National Committee on Detection, Evaluation, and Treatment of High Blood Pressure. Bethesda, MD: National Institutes of Health, No. 98-4080, 1997.
22. KAYSER, B. Nutrition and energetics of exercise at altitude: theory and possible practical implications. Sports Med. 17:309-323.
23. KETELHUT, R. G., K. KETELHUT, F. H. MESSERLI, and G. BADTKE. Fitness in the fit: does physical conditioning affect cardiovascular risk factors in middle-aged marathon runners? Eur. Heart J. 17: 199-203, 1996.
24. KOSKOLOU, M. D. and D. C. MCKENZIE. Arterial hypoxaemia and performance during intense exercise. Eur. J. Appl. Physiol. 68: 80-86, 1994.
25. LEVINE, B. D. and J. STRAY-GUNDERSEN. "Living high-training low": effect of moderate-altitude acclimatization with low-altitude training on performance. J. Appl. Physiol. 83:102-112, 1997.
26. LIU, Y., J. M. STEINACKER, C. DEHNERT, E. MENOLD, S. BAUR, W. LORMES, and M. LEHMANN. Effect of "living high-training low" on the cardiac functions at sea level. Int. J. Sports Med. 19:380-384, 1998.
27. LOKEY, E. A. and Z. V. TRAN. Effects of exercise-training on serum lipid and lipoprotein concentrations in women: a meta-analysis. Int. J. Sports Med. 10:424-429, 1989.
28. MEEHAN, R. T. Immune suppression at high altitude. Ann. Emerg Med. 16:974-979, 1987.
29. NYGÅRD, O., S. E. VOLLSET, H. REFSUM, et al. Total plasma homocysteine and cardiovascular risk profile: The Hordaland Homocysteine Study. JAMA 274:1526-1533, 1995.
30. PAFFENBARGER, R. S. JR., S. N. BLAIR, I. M. LEE, and R. T. HYDE. Measurement of physical activity to assess health effects in free-living populations. Med. Sci. Sports Exerc. 25:60-70, 1993.
31. RAVEN, P. B. and R. D. HAGAN. Cardiovascular responses to exercise and training. In: Oxford Textbook of Sports Medicine. M. Harries, C. Williams, W. Stanish, and L. Micheli (Eds.). London: Oxford University Press, 1994, pp. 161-172.
32. REFSUM, H., P. M. UELAND, O. NYGÅRD, and S. E. VOLLSET. Homocysteine and cardiovascular disease. Annu. Rev. Med. 49:31-62, 1998.
33. RICHALET, J. P., R. KACIMI, and A. M. ANTEZANA. The control of cardiac chronotropic function in hypobaric hypoxia. Int. J. Sports Med. 13:S22-24, 1992.
34. SHARMA, S. Clinical, biochemical, electrocardiographic and non-invasive hemodynamic assessment of cardiovascular status in natives at high to extreme altitudes (3000m-5500m) of the Himalaya region. Ind. Heart J. 42:375-379, 1990.
35. VOORS, A. C. W. and W. D. JOHNSON. Altitude and arteriosclerotic heart disease mortality in white residents of 99 of the 100 largest cities in the United States. J. Chr Dis. 32:157-162, 1979.
36. 2+ precipitation procedure for quantification of high-density lipoprotein cholesterol. Clin. Chem. 28:1379-1388, 1982.
37. WEISS, M., A. SCHMID, M. BAUM, and H. LIESEN. Influence of extensive exercise on plasma amino acids and plasma homocysteine (Abstract) Int. J. Sports Med. 19:S52, 1998.
38. WOLFEL, E. E., B. M. GROVES, G. A. BROOKS, et al. Oxygen transport during steady-state submaximal exercise in chronic hypoxia. J. Appl. Physiol. 70:1129-1136, 1991.
39. WOOD, P. D., M. L. STEFANICK, D. M. DREON, B. FREY-HEWITT, S. C. GARAY, and P. T. WILLIAMS. Changes in plasma lipids and lipoproteins in overweight men during weight loss through dieting as compared with exercise. N. Engl. J. Med. 319:1173-1179, 1988.