Down-regulation of opoid receptor gene expressions in T-lymphocytes of heroin users

Singapore Medical Journal

Volumn 41, Issue 3 SUPPL. 1, 2000, Pages 45-48

  Govitrapong, P ^a   Toskulkao, T ^a   Suttitum, T ^a   Akkarapatumwong, V ^b   Kotchabhakdi, N ^a   Vatanatunyakum, S ^c  

^a MAHIDOL UNIVERSITY   (Thailand)

^b MAHIDOL UNIVERSITY   (Thailand)

^c Thanyarak hospital   (Thailand)

Author keywords

Acquired immunodeficiency syndrome; Down regulation; Heroin addiction; Morphine; Opioid receptor

Indexed keywords

DELTA OPIATE RECEPTOR; DIAMORPHINE; MESSENGER RNA; MORPHINE; MU OPIATE RECEPTOR;

ADULT; CONFERENCE PAPER; CONTROLLED STUDY; DRUG RECEPTOR BINDING; HEROIN DEPENDENCE; HUMAN; HUMAN CELL; IMMUNOMODULATION; INTRAVENOUS DRUG ABUSE; LYMPHOCYTE PROLIFERATION; MALE; RECEPTOR DOWN REGULATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; T LYMPHOCYTE; THAILAND;

EID: 0034119767     PISSN: 00375675     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. Wongkhomthong SA, Kaime A, Ono K. AIDS in the Developing World: A Case Study in Thailand. Holistic Publishing, Bangkok, 1995.
2. Curran JW, Lawrence DN, Jaffe H, Kaplan JE, Zyla LD, Chamberland M, Weinstein R, Lui KJ, Schonberger LB, Spira TJ. Acquired immunodeficiency syndrome (AIDS) associated with transfusion. N Engl J Med 1984; 310:69-75.
3. Kitayaporn D, Uneklabh C, Weniger BG, Lohsomboom P, Kaewkangwal J, Morgan WM, Uneklabh T. HIV-cl incidence determined retrospectively among drug users in Bangkok, Thailand. AIDS 1994; 8:1443-50.
4. Govitrapong P, Suttitum T, Kotchabhakdi N, Uneklabh T. Alterations of immune functions in heroin addicts and heroin withdrawal subjects. J Pharmacol Exptl Ther 1998; 286:883-9.
5. Wick MJ, Minnerath SR, Roy S, Ramakrishman S, Loh HH. Differential expression of opioid receptor genes in human lymphoid cell lines and peripheral blood lymphocytes. Neuroimmunology 1996; 64:29-36.
6. Chuang LF, Chuang TK, Killiam KF Jr, Qiu Q, Wang XR, Lin J, Kung HF, Sheng W, Chao CC, Yu L, Chuang RY. Expression of kappa opioid receptor in human and monkey lymphocytes. Biochem Biophys Res Commun 1995; 209:1003-10.
7. Chuang TK, Killium KF Jr, Chuang LF, Kung HF, Sheng WS, Chao CC, Yu L, Chuang RY. Mu opioid receptor glial expression in immune cells. Biochem Biophys Res Commun 1995; 1216:926-30.
8. Wick MJ, Minnerath S R, Roy S, Ramakrishnan S, Loh HH. Expression of alternate forms of brain opioid "orphan" receptor mRNA in activated human peripheral blood lymphocytes and lymphocytic cell lines. Mol Brain Res 1995; 33:342-7.
9. Sacerdote P, Rubboli F, Locatelli L, Ciciliato I, Mantegazza P, Panerai AE. Pharmacological modulation of neuropeptides in peripheral mononuclear cells. J Neuroimmunol 1991; 32:35-41.
10. Wittert G, Hope P, Pyle D. Tissue distribution of opioid receptor gene expression in the rat. Biochem Biophys Res Commu 1996; 218:877-81.
11. Chetsawang B, Casalotti SO, Phansuwan-Pujito P, Kotchabhakdi N, Govitrapogn P. Gene expressions of opioid receptors and G-proteins in pineal glands. Biochem Biophys Res. Commu 1999; 262:775-80.
12. Thompson R, Mansour A, Akil H, Watson S. Cloning and pharmacological characterization of a rat mu opioid receptor. Neuron 1993; 11:903-13.
13. Abood ME. Molecular cloning and expression of a delta-opioid receptors from rat brain. J Neurosci Res 1994; 27:714-9.
14. Bot G, Blake AD, Li S, Reisine T. opioid regulation of the mouse d-opioid receptor expressed in human in embryonic kidney 293 cells. Mol Pharmacol 1997; 52: 272-81.
15. Trapaidze N, Keith DE, Cvejie S, Evan CJ, Devi LA. Sequestration of the d-opioid receptor: role of the C-terminus in agonist-mediated internalization. J Biol Chem 1996; 271:29279-85.
16. Chakrabarti S, Yong W, Law PY, Loh HH. The mu-opioid receptor down-regulates differently from the delta-opioid receptor reguirment of a high affinity receptor/G protein complex formation. Mol Pharmacol 1997; 53:105-13.