Studies on the recycling of the transferrin receptor in Trypanosoma brucei using an inducible gene expression system

European Journal of Biochemistry

Volumn 267, Issue 11, 2000, Pages 3309-3314

  Kabiri, Mostafa ^a   Steverding, Dietmar ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Inducible gene expression; Receptor recycling; Transferrin receptor; Trypanosoma brucei

Indexed keywords

TRANSFERRIN RECEPTOR;

ARTICLE; CALCULATION; ENDOCYTOSIS; GENE EXPRESSION SYSTEM; HALF LIFE TIME; NONHUMAN; PRIORITY JOURNAL; PROTEIN METABOLISM; PROTEIN TRANSPORT; TRYPANOSOMA BRUCEI;

ANIMALS; DIMERIZATION; ENDOCYTOSIS; GENE EXPRESSION REGULATION; GENES, MYC; GLYCOSYLPHOSPHATIDYLINOSITOLS; HALF-LIFE; LIGANDS; LYSOSOMES; MICE; MICE, KNOCKOUT; PROTOZOAN PROTEINS; RECEPTORS, TRANSFERRIN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSFECTION; TRYPANOSOMA BRUCEI BRUCEI;

EID: 0034119414     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1327.2000.01361.x     Document Type: Article

References (33)

1. 1. Steverding, D. (2000) The transferrin receptor of Trypanosoma brucei. Parasitol. Int. 48, 191-198.
2. 2. Steverding, D., Stierhof, Y.-D., Chaudhri, M., Ligtenberg, M., Schell, D., Beck-Sickinger, A.G. & Overath, P. (1994) ESAG 6 and 7 products of Trypanosoma brucei form a transferrin binding protein complex. Eur. J. Cell Biol. 64, 78-87.
3. 3. Chaudhri, M., Steverding, D., Kittelberger, D., Tjia, S. & Overath, P. (1994) Expression of a glycosylphosphatidylinositol-anchored Trypanosoma brucei transferrin-binding protein complex in insect cells. Proc. Natl Acad. Sci. USA 91, 6443-6447.
4. 4. Ligtenherg, M.J.L., Bitter, W., Kieft, R., Steverding, D., Janssen, H., Calafat, J. & Borst, P. (1994) Reconstitution of a surface transferrin binding complex in insect form Trypanosoma brucei. EMBO J. 13, 2565-2573.
5. 5. Salmon, D., Geuskens, M., Hanocq, F., Hanocq-Quertier, J., Nolan, D., Ruben, L. & Pays, E. (1994) A novel heterodimeric transferrin receptor encoded by a pair of VSG expression site-associated genes in T. brucei. Cell 78, 75-86.
6. 6. Steverding, D., Stierhof, Y.-D., Fuchs, H., Tauber, R. & Overath, P. (1995) Transferrin-binding protein complex is the receptor for transferrin uptake in Trypanosoma brucei. J. Cell Biol. 131, 1173-1182.
7. 7. Overath, P., Stierhof, Y.-D. & Wiese, M. (1997) Endocytosis and secretion in trypanosomatid parasites - tumultuous traffic in a pocket. Trends Cell Biol. 7, 27-33.
8. 8. Maier, A. & Steverding, D. (1996) Low affinity of Trypanosoma brucei transferrin receptor to apotransferrin at pH 5 explains the fate of the ligand during endocytosis. FEBS Lett. 396, 87-89.
9. 9. Grab, D.J., Wells, C.W., Shaw, M.K., Webster, P. & Russo, D.C.W. (1992) Endocytosed transferrin in African trypanosomes is delivered to lysosomes and may not be recycled. Eur. J. Cell Biol. 59, 398-404.
10. 10. Ansorge, I., Steverding, D., Melville, S., Hartmann, C. & Clayton, C. (1999) Transcription of 'inactive' expression sites in African trypanosomes leads to expression of multiple transferrin receptor RNAs in bloodstream forms. Mol. Biochem. Parasitol. 101, 81-94.
11. 11. Baltz, T., Baltz, D., Giroud, Ch. & Crockett, J. (1985) Cultivation in a semi-defined medium of animal infective forms of Trypanosoma brucei, T. equiperdum, T. evansi, T. rhodesiense and T. gambiense. EMBO J. 4, 1273-1277.
12. 12. Fast, B., Kremp, K., Boshart, M. & Steverding, D. (1999) Iron-dependent regulation of transferrin receptor expression in Trypanosoma brucei. Biochem. J. 342, 691-969.
13. 13. Goldstein, J.L., Brown, M.S., Anderson, R.G.W., Russell, D.W. & Schneider, W.J. (1985) Receptor-mediated endocytosis: concepts emerging from the LDL receptor system. Annu. Rev. Cell Biol. 1, 1-39.
14. 14. Omary, M.B. & Trowbridge, I.S. (1981) Biosynthesis of the human transferrin receptor in cultured cells. J. Biol. Chem. 256, 12888-12892.
15. 15. Tse, D.B., Cantor, C.R., McDowell, J. & Pernis, B. (1986) Recycling class I MHC antigens: dynamics of internalization, acidification and ligand-degradation in murine T lymphoblasts. J. Mol. Cell. Immunol. 2, 315-329.
16. 16. Smith, K.A. (1989) The interleukin 2 receptor. Annu. Rev. Cell Biol. 5, 397-425.
17. 17. Wirtz, L. & Clayton, C. (1995) Inducible gene expression in trypanosomes mediated by a prokaryotic repressor. Science 268, 1179-1183.
18. 18. Biebinger, S., Wirtz, L., Lorenz, P. & Clayton, C. (1997) Vectors for inducible expression of toxic gene products in bloodstream and procyclic Trypanosoma brucei. Mol. Biochem. Parasitol. 85, 99-112.
19. 19. Cully, D.F., Ip, H.S. & Cross, G.A.M. (1985) Coordinate transcription of variant surface glycoprotein genes and an expression site associated gene family in Trypanosoma brucei. Cell 42, 173-182.
20. 20. Kooter, J.M., van der Spek, H.J., Wagter, R., d'Oliveira, C.E., van der Hoeven, F., Johnson, P.J. & Borst, P. (1987) The anatomy and transcription of a telomeric expression site for variant-specific surface antigens in T. brucei. Cell 51, 261-272.
21. 21. Johnson, P.J., Kooter, J.M. & Borst, P. (1987) Inactivation of transcription by UV irradiation of T. brucei provides evidence for a multicistronic transcription unit including a VSG gene. Cell 51, 273-281.
22. 22. Pays, E., Tebabi, P., Pays, A., Coquelet, H., Revelard, P., Salmon, D. & Steinert, M. (1989) The genes and transcripts of an antigen gene expression site from T. brucei. Cell 57, 835-845.
23. 23. Zomerdijk, J.C.B.M., Ouellette, M., ten Asbroeck, A.L.M.A., Kieft, R., Bommer, A.M.M., Clayton, C.E. & Borst, P. (1990) The promoter for a variant surface glycoprotein gene expression site in Trypanosoma brucei. EMBO J. 9, 2791-2801.
24. 24. Ehlers, B., Czichos, J. & Overath, P. (1987) RNA turnover in Tryanosoma brucei. Mol. Cell. Biol. 7, 1242-1249.
25. 25. Schwartz, A.L., Fridovich, S.E. & Lodish, H.F. (1982) Kinetics of internalization and recycling of the asialoglycoprotein receptor in a hepatoma cell line. J. Biol. Chem. 257, 4230-4237.
26. 26. Ciechanover, A., Schwartz, A.L., Dautry-Varsat, A. & Lodish, H.F. (1983) Kinetics of internalization and recycling of transferrin and the transferrin receptor in a human hepaloma cell line. Effect of lysosomotropic agents. J. Biol. Chem. 258, 9681-9689.
27. 27. Steverding, D. (1998) Bloodstream forms of Trypanosoma brucei require only small amounts of iron for growth. Parasitol. Res. 84, 59-62.
28. 28. Basu, S.K., Goldstein, J.L., Andersen, R.G. & Brown, M.S. (1981) Monesin interrupts the recycling of low density lipoprotein receptors in human fibroblasts. Cell 24, 493-502.
29. 29. Harford, J., Bridges, K., Ashwell, G. & Klausner, R.D. (1983) Intracellular dissociation of receptor-bound asialoglycoproteins in cultured hepatocytes. A pH-mediated nonlysosomal event. J. Biol. Chem. 258, 3191-3197.
30. 30. Davis, C.G., Goldstein, J.L., Südhof, T.C., Andersen, R.G.W., Russell, D.W. & Brown, M.S. (1987) Acid-dependent ligand dissociation and recycling of LDL receptor mediated by growth factor homology region. Nature 326, 760-765.
31. 31. Bridges, K., Harford, J., Ashwell, G. & Klausner, R.D. (1982) Fate of receptor and ligand during endocytosis of asialoglycoproteins by isolated hepatocytes. Proc. Natl Acad. Sci. USA 79, 350-354.
32. 32. Geuze, H.J., Slot, J.W., Strous, G.J., Peppard, J., von Figura, K., Hasilik, A. & Schwarz, A.L. (1984) Intracellular receptor sorting during endocytosis: comparative immunoelectron microscopy of multiple receptors in rat liver. Cell 37, 195-204.
33. 33. McDowell, M.A., Ransom, D.M. & Bangs, J.D. (1998) Glycosylphosphatidylinositol-dependent secretory transport in Trypanosoma brucei. Biochem. J. 335, 681-689.