Effect of epidural epinephrine infusion with bupivacaine on labor pain and mother-fetus outcome in humans

Regional Anesthesia and Pain Medicine

Volumn 25, Issue 3, 2000, Pages 228-234

  Okutomi, Toshiyuki ^a,b   Mochizuki, Junko ^a   Amano, Kan ^a   Hoka, Sumio ^a  

^a KITASATO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b New York Presbyterian Hospital Columbia University Medical Center   (United States)

Author keywords

Epidural anesthesia; Epidural epinephrine; Labor and delivery; Uterine blood flow

Indexed keywords

ADRENALIN; BUPIVACAINE; LIDOCAINE;

ADULT; ARTICLE; CHILDBIRTH; CLINICAL ARTICLE; FEMALE; HUMAN; LABOR; MOTHER FETUS RELATIONSHIP; OBSTETRIC ANALGESIA; OUTCOMES RESEARCH; PAIN; PRIORITY JOURNAL;

EID: 0034119244     PISSN: 10987339     EISSN: None     Source Type: Journal    
DOI: 10.1097/00115550-200005000-00004     Document Type: Article

References (30)

1. Eisenach JC, Grice SC, Dewan DM. Epinephrine enhances analgesia produced by epidural bupivacaine during labor. Anesth Analg 1987;66:447-451.
2. Abboud TK, DerSarkissian L, Terrasi J, Murakawa K, Zhu J, Longhitano M. Comparative maternal, fetal and neonatal effects of chloroprocaine with and without epinephrine for epidural anesthesia in obstetrics. Anesth Analg 1987;66:71-75.
3. Abboud TK, Saul D, Nagappala S, Castandi J, Yanagi T, Haroutunian S, Yeh S-U. Maternal, fetal, and neonatal effects of lidocaine with and without epinephrine for epidural anesthesia in obstetrics. Anesth Analg 1984;63:973-979.
4. Abboud TK, Sheik-ol-Eslam A, Yanagi T, Murakawa K, Castandi J, Zakarian M, Hoffman D, Haroutunian S. Safety and efficacy of epinephrine added to bupivacaine for lumbar epidural analgesia in obstetrics. Anesth Analg 1985;64:585-591.
5. Mather LE, Tucker GI, Murphy TM, Stanton-Hicks MD'A, Bonica JJ. The effects of adding adrenaline to etidocaine lignocaine in extradural anaesthesia: II. Pharmacokinetics. Br J Anaesth 1976;48:989-994.
6. Tucker GI, Moore DC, Bridenbaugh PO, Bridenbaugh LD, Thompson GE. Systemic absorption of mepivacaine in commonly used regional procedures. Anesthesiology 1972;37:277-287.
7. Braid DP, Scott DB. The systemic absorption of local anaesthetic drugs. Br J Anaesth 1965;37:394-404.
8. Takasaki M, Kajitani H. Plasma lidocaine concentrations during continuous epidural infusion of lidocaine with and without epinephrine. Can J Anaesth 1990;37: 166-169.
9. Reynolds F, Taylor G. Plasma concentration of bupivacaine during continuous epidural analgesia in labour: The effect of adrenaline. Br J Anaesth 1971;43:436-440.
10. Burm AGL, van Kleef JW, Galdines MPRR, Olthof G, Spierdijk J. Epidural anesthesia with lidocaine and bupivacaine: Effects of epinephrine on the plasma concentration profile. Anesth Analg 1986;65:1281-1284.
11. Craft JB Jr, Epstein BS, Coakly CS. Effect of lidocaine with epinephrine versus lidocaine (plain) on induced labor. Anesth Analg 1972;51:243-246.
12. Dounas M, O'Kelly B, Jamali S, Mercier FJ, Benhamou D. Maternal and fetal effects adrenaline with bupivacaine (0.25%) for epidural analgesia during labour. Eur J Anaesth 1996;13:594-598.
13. Grice SC, Eisenach JC, Dewan DM. Labor analgesia with epidural bupivacaine plus fentanyl: Enhancement with epinephrine and inhibition with 2-chloroprocaine. Anesthesiology 1990;72:623-628.
14. Wallis KL, Shnider SM, Hicks JS, Spivey HT. Epidural anesthesia in the normotensive pregnant ewe: Effects on uterine blood flow and fetal acid-base status. Anesthesiology 1976;44:481-487.
15. Rosenfeld CR, Barton MD, Meschia G. Effects of epinephrine on distribution of blood flow in the pregnant ewe. Am J Obstet Gynecol 1976;124:156-163.
16. Hood DD, Dewan DM, James FM. Maternal and fetal effects of epinephrine in gravid ewes. Anesthesiology 1986;64:610-613.
17. deRosayro AM, Nahrwold ML, Hill AB. Cardiovascular effect of epidural epinephrine in the pregnant sheep. Reg Anesth 1981;6:4-7.
18. Norris MC, Grieco W, Arkoosh VA. Dose continuous intravenous infusion of low-concentration epinephrine impair uterine blood flow in pregnant ewes? Reg Anesth 1995;20:206-211.
19. Skjoldebrand A, Eklund J, Lunell N-O, Nylund L, Sarby B, Thornstrom S. The effect on uteroplacental blood flow of epidural anaesthesia containing adrenaline for caesarean section. Acta Anaesthesiol Scand 1990;34:85-89.
20. Albright GA, Jouppila R, Hollmen AI, Jouppila P, Vierola H, Koivula A. Epinephrine does not alter human intervillous blood flow during epidural anesthesia. Anesthesiology 1981;54:131-135.
21. Jouppila R, Jouppila P, Kuikka J, Hollmen A. Placental blood flow during caesarean section under lumbar extradural analgesia. Br J Anaesth 1978;50: 275-278.
22. Jouppila R, Jouppila P, Hollmen A, Kuikka J. Effect of segmental extradural analgesia on placental blood flow during normal labour. Br J Anaesth 1978;50:563-567.
23. Pearce JM, Campbell S, Cohen-Overbeek T, Hackett G, Hernandez J, Royston JP. Reference ranges and sources of variation for indices of pulsed Doppler flow velocity waveforms from the uteroplacental and fetal circulation. Br J Obstet Gynaecol 1988;95:248-256.
24. Thompson RS, Trudinger BJ, Cook CM, Giles WB. Doppler ultrasound waveform indices: AB ratio, pulsatility index and Pourcelot ratio. Br J Obstet Gynaecol 1988;95:589-591.
25. Wiegand UW, Chou RC, Lanz E, Jahnchen E. Determination of bupivacaine in human plasma by high-performance liquid chromatography. J Chromatogr 1984;311:218-222.
26. Caldeyro-Barcia R, Sica-Blanco Y, Poseiro JJ, Panizza VG, Mendez-Bauer C, Fielitz C, Alvarez H, Pose SV, Hendricks CH. A quantitative study of the action of synthetic oxytocin on the pregnant human uterus. J Pharmacol Exp Ther 1957;121:18-31.
27. Bromage PR, Camporesi EM, Durant PA, Nielsen CH. Influence of epinephrine as an adjuvant to epidural morphine. Anesthesiology 1983;58:257-262.
28. Bonica JJ, Akamatsu TJ, Berges PU, Morikawa K-I, Kennedy WF Jr. Circulatory effects if peridural block: II. Effects of epinephrine. Anesthesiology 1971;34:514-522.
29. Romero R, Goncalves LF, Ghezzi F, Munoz H, Cohen J, Gomez R, Mazor M. Doppler velocimetry of the uteroplacental circulation. In: Fleischer AC, Manning FA, Jeanty P, Romero R, eds. Sonography in Obstetrics and Gynecology. Principles and Practice. London, England: Prentice-Hall; 1996:311-327.
30. Milnor WR. Pulsatile blood flow. N Engl J Med 1972;287:27-34.