Simultaneous inhibition of renal phospholipase A2 and glutathione synthesis by manoalide and DL-buthionine sulfoximine induces acute tubular dysfunction in rats

Experimental Nephrology

Volumn 8, Issue 2, 2000, Pages 84-90

  Soejima, Akinori ^a   Ishizuka, Shunji ^a   Miyake, Nobuyuki ^a   Fukuoka, Kazuhito ^a   Suzuki, Michihiko ^a   Kamiya, Yasushi ^a   Nagasawa, Toshihiko ^a  

^a KYORIN UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Acute renal failure; DL Buthionine sulfoximine; Glutathione; Lipid peroxidation; Manoalide; Phospholipase A2

Indexed keywords

BUTHIONINE SULFOXIMINE; CREATINE; GENTAMICIN; GLUTATHIONE PEROXIDASE; MANOALIDE; PHOSPHOLIPASE A2;

ACUTE KIDNEY FAILURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG INDUCED DISEASE; ENZYME INHIBITION; ENZYME SYNTHESIS; MALE; NEPHROTOXICITY; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; RAT;

ACETYLGLUCOSAMINIDASE; ANIMALS; BUTHIONINE SULFOXIMINE; CREATININE; ENZYME INHIBITORS; GLUTATHIONE; KIDNEY; KINETICS; LYSOSOMES; MALE; PHOSPHOLIPASES A; PHOSPHOLIPIDS; RATS; RATS, SPRAGUE-DAWLEY; SILVER STAINING; TERPENES; THIOBARBITURIC ACID REACTIVE SUBSTANCES;

EID: 0034118890     PISSN: 10187782     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Walker PD, Shah SV: Gentamicin enhanced production of hydrogen peroxide by renal cortical mitochondria. Am J Physiol 1987;253: C495-C499.
2. Feldman S, Wang MY, Kaloyanides J: Aminoglycosides induce a phospholipidosis in the renal cortex of the rat: An early manifestation of nephrotoxicity. J Pharmacol Exp Ther 1982; 220:514-520.
3. Soejima A, Suzuki M, Ishizuka S, Fukuoka K, Nagasawa T: Lipid peroxidation and tubular disorder in experimenal acute renal failure: Enzymochemical study in the rat kidney. Jpn J Nephrol 1994;36:800-804.
4. Lipsky J, Lietman PS: Aminoglycoside inhibition of renal phosphatidylinositol phospholipasc C. J Pharmacol Exp Ther 1982;220:287-297.
5. Schwartz DW, Kreisgerg JI, Venkatachalam MA: Gentamicin-induced alterations in pig kidney epithelial (LLCPK-1) cells in culture. J Pharamcol Exp Ther 1986;236:254-262.
6. Molitoris BA, Simon RF: Renal cortical brushborder and basolateral membranes: Cholesterol and phospholipid composition and relative turnover. J Membr Biol 1985;83:207-215.
7. De Silva ED, Scheuer PJ: Manoalide, an antibiotic sesterterpenoid from the marine sponge Luffariella variabilis. Tetrahedron Lett 1980; 21:1611-1614.
8. Mayer AMS, Jacobs RS: Manoalide: An antiinflammatory and analgesic marine natural product; in Fautin DG (ed): Biomedical Importance of Marine Organisms. San Francisco, California Academy of Science, 1988, pp 133-142.
9. Hagiwara K, Naitou K, Kurokawa Y, Ichikawa T: Kidney injury induced by lipid peroxide produced by vitamin E deficiency and GSH depletion in rats. J Nutr Sci Vitaminol (Tokyo) 1991;37:99-107.
10. Griffith OW, Meister A: Glutathione: Interorgan translocation, turnover and metabolism. Proc Natl Acad Sci USA 1979;76:5605-5610.
11. Mahieu P, Winand RJ: Chemical structure of tubular and glomerular basement membranes of human kidney. Eur J Biochem 1970;12:410-418.
12. Owen CWI, Belcher RV: A colorimetric micromethod for the determination of glutathione. Biochem J 1965;94:705-711.
13. 2 activity of post-heparin plasma: A rapid and sensitive assay and partial characterization. Anal Biochem 1981;114:64-70.
14. Ohkawa H, Ohishi N, Yagi K: Assay for lipid peroxides in animal tissue by thiobarbituric acid reaction. Anal Biochem 1979;95:351-358.
15. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ: Protein measurement with the Folin phenol reagent. J Biol Chem 1951;193:265-275.
16. Noto A, Ogavva Y, Mori S, Yoshida M, Kitakaze T, Hori T, Nakamura M, Miyake T: Simple, rapid spectrophotometry of urinary N-acetyl-β-D-glucosaminidase with the use of a new chromogenic substrate. Clin Chem 1983;29: 1713-1716.
17. Humes HD, Weinberg JM: Toxic nephropathies: in Brenner BM, Rector FC (eds): The Kidney, ed 3. Philadelphia, B Saunders, 1986, pp 1491-1498.
18. Margoliash E, Novogrodsky A, Schejter A: Irreversible reaction of 3-amino-1:2:4-triazole and related inhibitors with the protein of catalase. Biochem J 1960;74:339-348.
19. 2 in mitochondria enriched with n-3 fatty acids. Proc Natl Acad Sci USA 1990; 87:8845-8849.
20. 2-induced injury in rat proximal tubules. Am J Physiol 1993;264:F94-F99.
21. 2 in cell damage. Arch Biochem Biophys 1993;301:119-128.
22. Soejima A, Ishizuka S, Suzuki M, Miyake N, Fukuoka K, Nagasawa T: Biochemical renal manifestations induced by consecutive administration of gentamicin in rats. Nephron 1998; 80:331-339.
23. Bennett CF, Mong S, Hsiao-Ling W, Wu W, Crooke ST: Inhibition of phosphoinositol-specific phospholipase C by manoalide. Pharmacologist 1986;28:192.
24. Meade CJ, Turner GA, Bateman PE: The role of polyphosphoinositides and their breakdown products in A23187 induced release of AA from rabbit polymorphonuclear leukocytes. Biochem J 1986;238:425-436.
25. Wheeler LA, Sachs G, De Vries G, Goodrum D, Woldemussie E, Muallem S: Manoalide, a natural sesterterpenoid that inhibits calcium channels. J Biol Chem 1987;62:6531-6538.
26. Olson CE: Glutathione modulates toxic oxygen metabolite injury of canine chief cell monolayers in primary culture. Am J Physiol 1988; 254:G49-G56.