Inducible nitric oxide synthase activity is expressed not only in inflamed but also in normal colonic mucosa in patients with ulcerative colitis: A potential prognostic marker [9]

American Journal of Gastroenterology

Volumn 95, Issue 5, 2000, Pages 1371-1373

  Colon A L ^a   Menchen L ^a,b   Lizasoain, I ^a   Leza, J C ^a   Menchen P ^b   Gonzalez Lara V ^b   Moro, M A ^a   Lorenzo, P ^a  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^b HOSPITAL GENERAL UNIVERSITARIO GREGORIO MARAÑÓN   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

MESALAZINE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRITE REDUCTASE; XANTHINE OXIDASE;

CLINICAL ARTICLE; COLITIS; COLON MUCOSA; COLONOSCOPY; CONTROLLED STUDY; DISEASE SEVERITY; ENTERITIS; ENZYME ACTIVITY; HUMAN; HUMAN TISSUE; INFLAMMATION; LETTER; PRIORITY JOURNAL; PROGNOSIS; ULCERATIVE COLITIS;

EID: 0034117388     PISSN: 00029270     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9270(00)00839-X     Document Type: Letter

References (9)

1. N.K Boughton-Smith S.M Evans C.J Hawkey Nitric oxide synthase activity in ulcerative colitis and Crohn’s disease Lancet 342 1993 338 340
2. J.O.N Lundberg P.M Hellström J.M Lundberg Greatly increased luminal nitric oxide in ulcerative colitis Lancet 344 1994 1673 1674
3. D Rachmilewitz J.S Stamler D Bachwich Enhanced colonic nitric oxide generation and nitric oxide synthase activity in ulcerative colitis and Crohn’s disease Gut 36 1995 718 723
4. S Moncada R.M.J Palmer E.A Higgs Nitric oxide Physiology, pathophysiology and pharmacology Pharmacol Rev 43 1991 109 142
5. H Kimura S Miura T Shigematsu Increased nitric oxide production and inducible nitric oxide synthase activity in colonic mucosa of patients with active ulcerative colitis and Crohn’s disease Dig Dis Sci 42 1997 1047 1054
6. G Kolios N Rooney C.T Murphy Expression of inducible nitric oxide synthase activity in human colon epithelial cells Modulation by T lymphocyte derived cytokines Gut 43 1998 56 63
7. J Kiss D Lamarque J.C Delchier Time-dependent actions of nitric oxide synthase inhibition on colonic inflammation induced by trinitrobenzene sulphonic acid in rats Eur J Pharmacol 336 1997 219 224
8. Z Zhang D.P Naughton E Carty Excess nitric oxide in ulcerative colitis may be generated by nitric oxide synthase independent pathways Gut 44 1999 441
9. B Zingarelli S Cuzzocrea C Szabó Mercaptoethylguanidine, a combined inhibitor of nitric oxide synthase and peroxynitrite scavenger, reduces trinitrobenzene sulfonic acid-induced colonic damage J Pharmacol Exp Ther 287 1998 1048 1055