Sorting and function of peroxisomal membrane proteins

FEMS Microbiology Reviews

Volumn 24, Issue 3, 2000, Pages 291-301

  Baerends, Richard J S ^a   Faber, Klaas Nico ^a   Kiel, Jan A K W ^a   Van Der Klei, Ida J ^a   Harder, Wim ^a   Veenhuis, Marten ^a  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

Author keywords

Biogenesis; Membrane protein; Peroxisome; Protein function; Protein sorting

Indexed keywords

ABC TRANSPORTER; MEMBRANE PROTEIN;

BIOGENESIS; CELL ORGANELLE; EUKARYOTIC CELL; GENE MUTATION; IMMUNOCYTOCHEMISTRY; NONHUMAN; PEROXISOME; PROTEIN PROCESSING; PROTEIN TARGETING; REVIEW; SACCHAROMYCES CEREVISIAE; TRANSPORT AT THE CELLULAR LEVEL;

ANIMALS; HUMANS; MEMBRANE PROTEINS; PEROXISOMES; PROTEIN PROCESSING, POST-TRANSLATIONAL;

EID: 0034115663     PISSN: 01686445     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-6445(99)00037-6     Document Type: Review

References (103)

1. Rhodin, J. (1954) Correlation of ultrastructural organization and function in normal and experimentally changed proximal convoluted cells of the mouse kidney. Ph.D. thesis, Stockholm.
2. De Duve, C. and Baudhuin, P. (1966) Peroxisomes (microbodies and related particles). Physiol. Rev. 46, 323-357.
3. van den Bosch, H., Schutgens, R.B.H., Wanders, R.J.A. and Tager, J.M. (1992) Biochemistry of peroxisomes. Annu. Rev. Biochem. 61, 157-197.
4. Distel, B., Erdmann, R., Gould, S.J., Blobel, G., Crane, D.I., Cregg, J.M., Dodt, G., Fujiki, Y., Goodman, J.M., Just, W.W., Kiel, J.A.K.W., Kunau, W.-H., Lazarow, P.B., Mannaerts, G.P., Moser, H.W., Osumi, T., Rachubinski, R.A., Roscher, A., Subramani, S., Tabak, H.F., Tsukamoto, T., Valle, D., van der Klei, I., van Veldhoven, P.P. and Veenhuis, M. (1996) A unified nomenclature for peroxisome biogenesis factors. J. Cell Biol. 135, 1-3.
5. Geraghty, M.T., Bassett, D., Morrell, J.C., Gatto Jr., G.J., Bai, J., Geisbrecht, B.V., Hieter, P. and Gould, S.J. (1999) Detecting patterns of protein distribution and gene expression in silico. Proc. Natl. Acad. Sci. USA 96, 2937-2942.
6. Kal, A.J., van Zonneveld, A.J., Benes, V., van den Berg, M., Groot Koerkamp, M., Albermann, K., Strack, N., Ruijter, J.M., Richter, A., Dujon, B., Ansorge, W. and Tabak, H.F. (1999) Dynamics of gene expression revealed by comparison of serial analysis of gene expression transcript profiles from yeast grown on two different carbon sources. Mol. Biol. Cell 10, 1859-1872.
7. van Veldhoven, P.P. and Mannaerts, G.P. (1994) Assembly of the peroxisomal membrane. In: Subcellular Biochemistry, Membrane Biogenesis, Vol. 22 (Maddy, A.H. and Harris, J.R., Eds.), pp. 231-261. Plenum Press, New York.
8. Baerends, R.J.S., Rasmussen, S.W., Hilbrands, R.E., van der Heide, M., Faber, K.N., Reuvekamp, P.T.W., Kiel, J.A.K.W., Cregg, J.M., van der Klei, I.J. and Veenhuis, M. (1996) The Hansenula polymorpha PER9 gene encodes a peroxisomal membrane protein essential for peroxisome assembly and integrity. J. Biol. Chem. 271, 8887-8894.
9. Salomons, F.A., van der Klei, I.J., Kram, A.M., Harder, W. and Veenhuis, M. (1997) Brefeldin A interferes with peroxisomal protein sorting in the yeast Hansenula polymorpha. FEBS Lett. 411, 133-139.
10. Elgersma, Y., Kwast, L., van den Berg, M., Snyder, W.B., Distel, B., Subramani, S. and Tabak, H.F. (1997) Overexpression of Pex15p, a phosphorylated peroxisomal integral membrane protein required for peroxisome assembly in S. cerevisiae, causes proliferation of the endoplasmic reticulum membrane. EMBO J. 16, 7326-7341.
11. Faber, K.N., Heyman, J.A. and Subramani, S. (1998) Two AAA family peroxins, PpPex1p and PpPex6p, interact with each other in an ATP-dependent manner and are associated with different subcellular membranous structures distinct from peroxisomes. Mol. Cell. Biol. 18, 936-943.
12. Titorenko, V.I. and Rachubinski, R.A. (1998) Mutants of the yeast Yarrowia lipolytica defective in protein exit from the endoplasmic reticulum are also defective in peroxisome biogenesis. Mol. Cell. Biol. 18, 2789-2803.
13. Erdmann, R., Veenhuis, M. and Kunau, W.-H. (1997) Peroxisomes: organelles at the crossroads. Trends Cell Biol. 7, 400-407.
14. Subramani, S. (1998) Components involved in peroxisome import, biogenesis, proliferation, turnover and movement. Physiol. Rev. 78, 171-188.
15. van der Klei, I.J., Hilbrands, R.E., Kiel, J.A.K.W., Rasmussen, S.W., Cregg, J.M. and Veenhuis, M. (1998) The ubiquitin-conjugating enzyme Pex4p of Hansenula polymorpha is required for efficient functioning of the PTS1 import machinery. EMBO J. 17, 3608-3618.
16. Lüers, G., Beier, K., Hashimoto, T., Fahimi, H.D. and Volkl, A. (1990) Biogenesis of peroxisomes: sequential biosynthesis of the membrane and matrix proteins in the course of hepatic regeneration. Eur. J. Cell Biol. 52, 175-184.
17. Veenhuis, M. and Goodman, J.M. (1990) Peroxisomal assembly: membrane proliferation precedes the induction of the abundant matrix proteins in the methylotrophic yeast Candida boidinii. J. Cell Sci. 96, 583-590.
18. Erdmann, R. and Blobel, G. (1995) Giant peroxisomes in oleic acid-induced Saccharomyces cerevisiae lacking the peroxisomal membrane protein Pmp27p. J. Cell Biol. 128, 509-523.
19. Sulter, G.J., Looyenga, L., Veenhuis, M. and Harder, W. (1990) Occurrence of peroxisomal membrane proteins in methylotrophic yeasts grown under different conditions. Yeast 6, 35-43.
20. van der Klei, I.J. and Veenhuis, M. (1997) Yeast peroxisomes: function and biogenesis of a versatile cell organelle. Trends Microbiol. 5, 502-509.
21. Rottensteiner, H., Kal, A.J., Filipits, M., Binder, M., Hamilton, B., Tabak, H.F. and Ruis, H. (1996) Pip2p: a transcriptional regulator of peroxisome proliferation in the yeast Saccharomyces cerevisiae. EMBO J. 15, 2924-2934.
22. Karpichev, I.V. and Small, G.M. (1998) Global regulatory functions of Oaf1p and Pip2p (Oaf2p), transcription factors that regulate genes encoding peroxisomal proteins in Saccharomyces cerevisiae. Mol. Cell Biol. 18, 6560-6570.
23. Marshall, P.A., Krimkevich, Y.I., Lark, R.H., Dyer, J.M., Veenhuis, M. and Goodman, J.M. (1995) Pmp27 promotes peroxisomal proliferation. J. Cell Biol. 129, 345-355.
24. Lorenz, P., Maier, A.G., Baumgart, E., Erdmann, R. and Clayton, C. (1998) Elongation and clustering of glycosomes in Trypanosoma brucei overexpressing the glycosomal Pex11p. EMBO J. 17, 3542-3555.
25. Passreiter, M., Anton, M., Lay, D., Frank, R., Harter, C., Wieland, F.T., Gorgas, K. and Just, W.W. (1998) Peroxisome biogenesis: involvement of ARF and coatomer. J. Cell Biol. 141, 373-383.
26. Schrader, M., Reuber, B.E., Morrell, J.C., Jimenez-Sanchez, G., Obie, C., Stroh, T.A., Valle, D., Schroer, T.A. and Gould, S.J. (1998) Expression of PEX11β mediates peroxisome proliferation in the absence of extracellular stimuli. J. Biol. Chem. 273, 29607-29614.
27. Marshall, P.A., Dyer, J.M., Quick, M.E. and Goodman, J.M. (1996) Redox-sensitive homodimerization of Pex11p: a proposed mechanism to regulate peroxisomal division. J. Cell Biol. 135, 123-137.
28. Abe, I., Okumoto, K., Tamura, S. and Fujiki, Y. (1998) Clofibrate-inducible, 28-kDa peroxisomal integral membrane protein is encoded by PEX11. FEBS Lett. 431, 468-472.
29. Abe, I. and Fujiki, Y. (1998) cDNA cloning and characterization of a constitutively expressed isoform of the human peroxin Pex11p. Biochem. Biophys. Res. Commun. 252, 529-533.
30. Cosson, P. and Letourneur, F. (1994) Coatomer interaction with dilysine endoplasmatic reticulum motifs. Science 263, 1629-1631.
31. Tan, X., Waterham, H.R., Veenhuis, M. and Cregg, J.M. (1995) The Hansenula polymorpha PER8 gene encodes a novel peroxisomal integral membrane protein involved in proliferation. J. Cell Biol. 128, 307-319.
32. Eitzen, G.A., Szilard, R.K. and Rachubinski, R.A. (1997) Enlarged peroxisomes are present in oleic acid-grown Yarrowia lipolytica over-expressing the PEX16 gene encoding an intraperoxisomal peripheral membrane peroxin. J. Cell Biol. 137, 1265-1278.
33. Baerends, R.J.S., Salomons, F.A., Faber, K.N., Kiel, J.A.K.W., van der Klei, I.J. and Veenhuis, M. (1997) Deviant Pex3p levels affect normal peroxisome formation in Hansenula polymorpha: high steady-state levels of the protein fully abolish matrix protein import. Yeast 13, 1437-1448.
34. Baerends, R.J.S., Salomons, F.A., Kiel, J.A.K.W., van der Klei, I.J. and Veenhuis, M., Deviant Pex3p levels affect normal peroxisome formation in Hansenula polymorpha: a sharp increase of the protein level induces the proliferation of numerous, small protein-import competent peroxisomes. Yeast 13, 1449-1463.
35. Komori, M., Rasmussen, S.W., Kiel, J.A.K.W., Baerends, R.J.S., Cregg, J.M., van der Klei, I.J. and Veenhuis, M. (1997) The Hansenula polymorpha PEX14 gene encodes a novel peroxisomal membrane protein essential for peroxisome biogenesis. EMBO J. 16, 44-53.
36. Baerends, R.J.S., Rasmussen, S.W., Hilbrands, R.E., van der Heide, M., Faber, K.N., Reuvekamp, P.T.W., Kiel, J.A.K.W., Cregg, J.M., van der Klei, I.J. and Veenhuis, M. (1996) The Hansenula polymorpha PER9 gene encodes a peroxisomal membrane protein essential for peroxisome assembly and integrity. J. Biol. Chem. 271, 8887-8894.
37. Wiemer, E.A.C., Lüers, G.H., Faber, K.N., Wenzel, T., Veenhuis, M. and Subramani, S. (1996) Isolation and characterization of Pas2p, a peroxisomal membrane protein essential for peroxisome biogenesis in the methylotrophic yeast Pichia pastoris. J. Biol. Chem. 271, 18973-18980.
38. Götte, K., Girzalsky, W., Linkert, M., Baumgart, E., Kammerer, S., Kunau, W.-H. and Erdmann, R. (1998) Pex19p, a farnesylated protein essential for peroxisome biogenesis. Mol. Cell. Biol. 18, 616-628.
39. Snyder, W.B., Faber, K.N., Wenzel, T.J., Koller, A., Lüers, G.H., Rangell, L., Keller, G.A. and Subramani, S. (1999) Pex19p interacts with Pex3p and Pex10p and is essential for peroxisome biogenesis in Pichia pastoris. Mol. Biol. Cell 10, 1745-1761.
40. Soukupova, M., Sprenger, C., Gorgas, K., Kunau, W.-H. and Dodt, G. (1999) Identification and characterization of the human peroxin PEX3. Eur. J. Cell Biol. 78, 357-374.
41. McCammon, M.T., Dowds, C.A., Orth, K., Moomaw, C.R., Slaughter, C.A. and Goodman, J.M. (1990) Sorting of peroxisomal membrane protein PMP47 from Candida boidinii into peroxisomal membranes of Saccharomyces cerevisiae. J. Biol. Chem. 265, 20098-20105.
42. Sulter, G.J., Waterham, H.R., Vrieling, E.G., Goodman, J.M., Harder, W. and Veenhuis, M. (1993) Expression and targeting of a 47 kDa integral peroxisomal membrane protein of Candida boidinii in wild-type and a peroxisome-deficient mutant of Hansenula polymorpha. FEBS Lett. 315, 211-216.
43. Kiel, J.A.K.W., Keizer-Gunnink, I.K., Krause, T., Komori, M. and Veenhuis, M. (1995) Heterologous complementation of peroxisome function in yeast: the Saccharomyces cerevisiae PAS3 gene restores peroxisome biogenesis in a Hansenula polymorpha per9 disruption mutant. FEBS Lett. 377, 434-438.
44. Sakai, Y., Marshall, P.A., Saiganji, A., Takabe, K., Saiki, H., Kato, N. and Goodman, J.M. (1995) The Candida boidinii peroxisomal membrane protein Pmp30 has a role in peroxisomal proliferation and is functionally homologous to Pmp27 from Saccharomyces cerevisiae. J. Bacteriol. 177, 6773-6781.
45. Elgersma, Y., Kwast, L., Klein, A., Voorn-Brouwer, T., van den Berg, M., Metzig, B., America, T., Tabak, H.F. and Distel, B. (1996) The SH3 domain of the Saccharomyces cerevisiae peroxisomal membrane protein Pex13p functions as a docking site for Pex5p, a mobile receptor for the import of PTS1-containing proteins. J. Cell Biol. 135, 97-109.
46. Fujiki, Y., Rachubinski, R.A. and Lazarow, P.B. (1984) Synthesis of a major integral membrane polypeptide of rat liver peroxisomes on free polysemes. Proc. Natl. Acad. Sci. USA 81, 7127-7131.
47. Suzuki, Y., Orii, T., Takiguchi, M., Mori, M., Hijikata, M. and Hashimoto, T. (1987) Biosynthesis of membrane polypeptides of rat liver peroxisomes. J. Biochem. (Tokyo) 101, 491-496.
48. Just, W.W. and Hartl, F.-U. (1987) Peroxisomes in Biology and Medicine (Fahimi, H.D. and Sie, H., Eds.), pp. 402-416. Springer-Verlag, Heidelberg.
49. Diestelkötter, P. and Just, W.W. (1993) In vitro insertion of the 22-kDa peroxisomal membrane protein into isolated rat liver peroxisomes. J. Cell Biol. 123, 1717-1725.
50. Just, W.W. and Diestelkötter, P. (1996) Protein insertion into the peroxisomal membrane. Ann. N.Y. Acad. Sci. 804, 60-75.
51. Imanaka, T., Shiina, Y., Takano, T., Hashimoto, T. and Osumi, T. (1996) Insertion of the 70-kDa peroxisomal membrane protein into peroxisomal membranes in vivo and in vitro. J. Biol. Chem. 271, 3706-3713.
52. Titorenko, V.I., Ogrydziak, D.M. and Rachubinski, R.A. (1997) Four distinct secretory pathways serve protein secretion, cell surface growth, and peroxisome biogenesis in the yeast Yarrowia lipolytica. Mol. Cell. Biol. 17, 5210-5226.
53. Honsho, M., Tamura, S., Shimozawa, N., Suzuki, Y., Kondo, N. and Fujiki, Y. (1998) Mutation in PEX16 is causal in the peroxisome-deficient Zellweger syndrome of complementation group D. Am. J. Hum. Genet. 63, 1622-1630.
54. South, S.T. and Gould, S.J. (1999) Peroxisome synthesis in the absence pf preexisting peroxisomes. J. Cell Biol. 144, 255-266.
55. Elgersma, Y., Kwast, L., van den Berg, M., Snyder, W.B., Distel, B., Subramani, S. and Tabak, H.F. (1997) Overexpression of Pex15p, a phosphorylated peroxisomal integral membrane protein required for peroxisome assembly in S. cerevisiae, causes proliferation of the endoplasmic reticulum membrane. EMBO J. 16, 7326-7341.
56. Dyer, J.M., McNew, J.A. and Goodman, J.M. (1996) The sorting sequence of the peroxisomal integral membrane protein PMP47 is contained within a short hydrophilic loop. J. Cell Biol. 133, 269-280.
57. Kammerer, S., Holzinger, A., Welsch, U. and Roscher, A.A. (1998) Cloning and characterization of the gene encoding the human peroxisomal assembly protein Pex3p. FEBS Lett. 429, 53-60.
58. Komori, M., Kiel, J.A.K.W. and Veenhuis, M. (1999) The peroxisomal membrane protein Pex14p of Hansenula polymorpha is phosphorylated in vivo. FEBS Lett. 457, 397-399.
59. Matsuzono, Y., Kinoshita, N., Tamura, S., Shimozawa, N., Hamasaki, M., Ghaedi, K., Wanders, R.J.A., Suzuki, Y., Kondo, N. and Fujiki, Y. (1999) Human PEX19: cDNA cloning by functional complementation, mutation analysis in a patient with Zellweger syndrome, and potential role in peroxisomal membrane assembly. Proc. Natl. Acad. Sci. USA 96, 2116-2121.
60. Zhang, F.L. and Casey, P.J. (1996) Protein prenylation: molecular mechanisms and functional consequences. Annu. Rev. Biochem. 65, 241-269.
61. Boutin, J.A., Marande, W., Petit, L., Loynel, A., Desmet, C., Canet, E. and Fauchère, J.-L. (1999) Investigations of S-farnesyl transferase substrate specificity with combinatorial tetrapeptide libraries. Cell. Signal. 11, 59-69.
62. Pause, B., Diestelkötter, P., Heid, H. and Just, W.W. (1997) Cytosolic factors mediate protein insertion into the peroxisomal membrane. FEBS Lett. 414, 95-98.
63. Wirtz, K.W.A. (1982) Lipid-Protein Interactions (Jost, P. and Griffith, O.H., Eds.), pp. 151-231. Wiley, New York.
64. Schrader, M., Burkhardt, J.K., Baumgart, E., Lüers, G., Spring, H., Völkl, A. and Fahimi, H.D. (1996) Interaction of microtubules with peroxisomes. Tubular and spherical peroxisomes in HepG2 cells and their alterations induced by microtubule-active drugs. Eur. J. Cell Biol. 69, 24-35.
65. 2 signaling cascade is involved in the regulation of peroxisomal motility in CHO cells. J. Cell Sci. 110, 2955-2968.
66. Wiemer, E.A.C., Wenzel, T., Deerinck, T.J., Ellisman, M.H. and Subramani, S. (1997) Visualization of the peroxisomal compartment in living mammalian cells: dynamic behavior and association with microtubules. J. Cell Biol. 136, 71-80.
67. Purdue, P.E., Yang, X. and Lazarow, P.B. (1998) Pex18p and Pex21p, a novel pair of related peroxins essential for peroxisomal targeting by the PTS2 pathway. J. Cell Biol. 143, 1859-1869.
68. Kiel, J.A.K.W., Rechinger, K.B., van der Klei, I.J., Salomons, F.A., Titorenko, V.I. and Veenhuis, M. (1999) The Hansenula polymorpha PDD1 gene product, essential for the selective degradation of peroxisomes, is a homologue of Saccharomyces cerevisiae Vps34p. Yeast 15, 741-754.
69. Elgersma, Y. and Tabak, H.F. (1996) Proteins involved in peroxisome biogenesis and functioning. Biochim. Biophys. Acta 1286, 269-283.
70. 31P NMR study of the internal pH of yeast peroxisomes. Arch. Microbiol. 147, 37-41.
71. Waterham, H.R., Keizer-Gunnink, I., Goodman, J.M., Harder, W. and Veenhuis, M. (1990) Immunocytochemical evidence for the acidic nature of peroxisomes of methylotrophic yeasts. FEBS Lett. 262, 17-19.
72. Baumgart, E., Fahimi, H.D., Stich, A. and Völkl, A. (1996) L-lactate dehydrogenase A4- and A3B isoforms are bona fide peroxisomal enzymes in rat liver. Evidence for involvement in intraperoxisomal NADH reoxidation. J. Biol. Chem. 271, 3846-3855.
73. van Roermund, C.W., Hettema, E.H., Kal, A.J., van den Berg, M., Tabak, H.F. and Wanders, R.J.A. (1998) Peroxisomal beta-oxidation of polyunsaturated fatty acids in Saccharomyces cerevisiae: isocitrate dehydrogenase provides NADPH for reduction of double bonds at even positions. EMBO J. 17, 677-687.
74. Jank, B., Habermann, B., Schweyen, R.J. and Link, T.A. (1993) PMP47, a peroxisomal homologue of mitochondrial solute carrier proteins. Trends Biochem. Sci. 18, 427-428.
75. McCammon, M.T., McNew, J.A., Willy, P.J. and Goodman, J.M. (1994) An internal region of the peroxisomal membrane protein PMP47 is essential for sorting to peroxisomes. J. Cell Biol. 124, 915-925.
76. Kuan, J. and Saier Jr., M.H.J. (1993) The mitochondrial carrier family of transport proteins: structural, functional, and evolutionary relationships. Crit. Rev. Biochem. Mol. Biol. 28, 209-233.
77. Sakai, Y., Saiganji, A., Yurimoto, H., Takabe, K., Saiki, H. and Kato, N. (1996) The absence of Pmp47, a putative yeast peroxisomal transporter, causes a defect in transport and folding of a specific matrix enzyme. J. Cell Biol. 134, 37-51.
78. Wylin, T., Baes, M., Brees, C., Mannaerts, G.P., Fransen, M. and van Veldhoven, P.P. (1998) Identification and characterization of human PMP34, a protein closely related to the peroxisomal integral membrane protein PMP47 of Candida boidinii. Eur. J. Biochem. 258, 332-338.
79. 2+-dependent member of the mitochondrial carrier superfamily. Proc. Natl. Acad. Sci. USA 94, 8509-8514.
80. Mosser, J., Douar, A.M., Sarde, C.O., Kioschis, P., Feil, R., Moser, H., Poustka, A.M., Mandel, J.L. and Aubourg, P. (1993) Putative X-linked adrenoleukodystrophy gene shares unexpected homology with ABC transporters. Nature 361, 726-730.
81. Mosser, J., Lutz, Y., Stoeckel, M.E., Sarde, C.O., Kretz, C., Douar, A.M., Lopez, J., Aubourg, P. and Mandel, J.L. (1994) The gene responsible for adrenoleukodystrophy encodes a peroxisomal membrane protein. Hum. Mol. Genet. 3, 265-271.
82. Kamijo, K., Taketani, S., Yokota, S., Osumi, T. and Hashimoto, T. (1990) The 70-kDa peroxisomal membrane protein is a member of the Mdr (P-glycoprotein)-related ATP-binding protein superfamily. J. Biol. Chem. 265, 4534-4540.
83. Gärtner, J., Moser, H. and Valle, D. (1992) Mutations in the 70K peroxisomal membrane protein gene in Zellweger syndrome. Nat. Genet. 1, 16-23.
84. Lombard-Platet, G., Savary, S., Sarde, C.O., Mandel, J.L. and Chimini, G. (1996) A close relative of the adrenoleukodystrophy (ALD) gene codes for a peroxisomal protein with a specific expression pattern. Proc. Natl. Acad. Sci. USA 93, 1265-1269.
85. Shani, N., Jimenez-Sanchez, G., Steel, G., Dean, M. and Valle, D. (1997) Identification of a fourth half ABC transporter in the human peroxisomal membrane. Hum. Mol. Genet. 6, 1925-1931.
86. Holzinger, A., Roscher, A.A., Landgraf, P., Lichtner, P. and Kammerer, S. (1998) Genomic organization and chromosomal localization of the human peroxisomal membrane protein-1-like protein (PXMP1-L) gene encoding a peroxisomal ABC transporter. FEBS Lett. 426, 238-242.
87. Holzinger, A., Muntau, A., Mayerhofer, P., Kammerer, S., Albet, S., Bugaut, M. and Roscher, A.A. (1998) The mouse gene encoding the peroxisomal membrane protein 1-like protein (PXMP1-L): cDNA cloning, genomic organization and comparative expression studies. FEBS Lett. 433, 179-183.
88. Higgins, C.F. (1992) ABC transporters: from microorganisms to man. Annu. Rev. Cell Biol. 8, 67-113.
89. Walker, J.E., Saraste, M., Runswick, M.J. and Gay, N.J. (1982) Distantly related sequences in the α- and β-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold. EMBO J. 1, 945-981.
90. Braverman, N., Dodt, G., Gould, S.J. and Valle, D. (1995) Disorders of peroxisome biogenesis. Hum. Mol. Genet. 4, 1791-1798.
91. Shani, N., Watkins, P.A. and Valle, D. (1995) PXA1, a possible Saccharomyces cerevisiae ortholog of the human adrenoleukodystrophy gene. Proc. Natl. Acad. Sci. USA 92, 6006-6012.
92. Hettema, E.H., van Roermund, C.W., Distel, B., van den Berg, M., Vilela, C., Rodrigues-Pousada, C., Wanders, R.J.A. and Tabak, H.F. (1996) The ABC transporter proteins Pat1 and Pat2 are required for import of long-chain fatty acids into peroxisomes of Saccharomyces cerevisiae. EMBO J. 15, 3813-3822.
93. Shani, N. and Valle, D. (1996) A Saccharomyces cerevisiae homolog of the human adrenoleukodystrophy transporter is a heterodimer of two half ATP-binding cassette transporters. Proc. Natl. Acad. Sci. USA 93, 11901-11906.
94. Swartzman, E.E., Viswanathan, M.N. and Thorner, J. (1996) The PAL1 gene product is a peroxisomal ATP-binding cassette transporter in the yeast Saccharomyces cerevisiae. J. Cell Biol. 132, 549-563.
95. Shani, N. and Valle, D. (1998) Peroxisomal ABC transporters. Methods Enzymol. 292, 753-776.
96. Glover, J.R., Andrews, D.W. and Rachubinski, R.A. (1994) Saccharomyces cerevisiae peroxisomal thiolase is imported as a dimer. Proc. Natl. Acad. Sci. USA 91, 10541-10545.
97. Waterham, H.R., Russell, K.A., Vries, Y. and Cregg, J.M. (1997) Peroxisomal targeting, import, and assembly of alcohol oxidase in Pichia pastoris. J. Cell Biol. 139, 1419-1431.
98. Waterham, H.R., Titorenko, V.I., Swaving, G.J., Harder, W. and Veenhuis, M. (1993) Peroxisomes in the methylotrophic yeast Hansenula polymorpha do not necessarily derive from pre-existing organelles. EMBO J. 12, 4785-4794.
99. Sulter, G.J., Verheyden, K., Mannaerts, G., Harder, W. and Veenhuis, M. (1993) The in vitro permeability of yeast peroxisomal membranes is caused by a 31 kDa integral membrane protein. Yeast 9, 733-742.
100. Garrard, L.J. and Goodman, J.M. (1989) Two genes encode the major membrane-associated protein of methanol-induced peroxisomes from Candida boidinii. J. Biol. Chem. 264, 13929-13937.
101. Randez-Gil, F., Prieto, J.A. and Sanz, P. (1994) Nucleotide sequence of a putative peroxisomal protein from the yeast lipomyces kononenkoae. FEMS Microbiol. Lett. 122, 153-158.
102. Yamashita, H., Avraham, S., Jiang, S., London, R., van Veldhoven, P.P., Subramani, S., Rogers, R.A. and Avraham, H. (1999) Characterization of human and murine PMP20 peroxisomal proteins that exhibit antioxidant activity in vitro. J. Biol. Chem. 274, 29897-29904.
103. Kaldi, K., Diestelkötter, P., Stenbeck, G., Auerbach, S., Jäckle, U., Mägert, H.-J., Wieland, F.T. and Just, W.W. (1993) Membrane topology of the 22 kDa integral peroxisomal membrane protein. FEBS Lett. 315, 217-222.