Structure-specificity relationship of cardiac glycosides as a substrate for glucohydrolase II

Chemical and Pharmaceutical Bulletin

Volumn 48, Issue 3, 2000, Pages 349-352

  Terada, Yukimasa ^a   Misoi, Rumi ^a   Watanabe, Naoharu ^b   Hornberger, Martin ^c   Kreis, Wolfgang ^c  

^a MEIJO UNIVERSITY   (Japan)

^b SHIZUOKA UNIVERSITY   (Japan)

^c UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

Cardenolide glucohydrolase II (CGH II); Cardiac glycoside; Conformation analysis; Molecular mechanics; Structure specificity relationship

Indexed keywords

CARDIAC GLYCOSIDE; GLUCOSIDASE;

ARTICLE; CHEMICAL STRUCTURE; CONFORMATIONAL TRANSITION; ENZYME SPECIFICITY; ENZYME SUBSTRATE; HYDROGEN BOND; MOLECULAR RECOGNITION;

EID: 0034114512     PISSN: 00092363     EISSN: None     Source Type: Journal    
DOI: 10.1248/cpb.48.349     Document Type: Article

References (11)

1. Wichtl M., Mangkudidjojo M., Pharm. Zeitung, 129, 686-689 (1984).
2. Stoll A., Hoffmann A., Kreis W., Hoppe-Seyler's Z. Physiol. Chem., 235, 249-264 (1935).
3. May U., Kreis W., Plant Physiol. Biochem., 35 (7), 523-532 (1997).
4. Hornberger M., Kreis W., Plant Physiol. Biochem., in press.
5. Insight II Program Package, ver. 95.0, Biosym/MSI, San Diego, CA, U.S.A. (1995).
6. Discover Program Package, ver. 2.9.7, Biosym/MSI, San Diego, CA, U.S.A. (1995).
7. Allinger N. L., Wu F., Tetrahedron, 27, 5093-5113 (1971).
8. Bowden K., "Comprehensive Medicinal Chemistry," Vol. 4, ed. by Hansch C., Pergamon Press, Oxford, 1990, pp. 220-221.
9. Burkert U., Allinger N. L., "Molecular Mechanics," ACS Monograph. 177, 1982, pp. 59-78.
10. Pettersson I., Liljefors T., J. Comput.-Aid. Mol. Des., 1, 143-152 (1987).
11. Theurer C., Treumann H.-J., Faust T., May U., Kreis W., Plant Cell, Tissue and Organ Culture, 38, 327-335 (1994).