Adenylate cyclase and potassium channels are involved in forskolin- and 1,9-dideoxyforskolin-induced inhibition of pregnant rat uterus contractility

American Journal of Obstetrics and Gynecology

Volumn 182, Issue 3, 2000, Pages 620-624

  Vedernikov, Yuri P ^a   Syal, Ashu S ^a   Okawa, Toshiaki ^a   Saade, George R ^a   Garfield, Robert E ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

Author keywords

1,9 dideoxyforskolin; Adenylate cyclases; Forskolin; Glibenclamide; MDL 12,330A; Potassium channels; Tetrabutylammonium chloride

Indexed keywords

1,9 DIDEOXYFORSKOLIN; ADENYLATE CYCLASE; CALCIUM CHANNEL; FORSKOLIN; GLIBENCLAMIDE; N (2 PHENYLCYCLOPENTYL)AZACYCLOTRIDECAN 2 IMINE; POTASSIUM CHANNEL; TETRABUTYLAMMONIUM;

ANIMAL TISSUE; ARTICLE; DRUG EFFECT; ENZYME ACTIVATION; FEMALE; NONHUMAN; PREGNANCY; PRIORITY JOURNAL; RAT; UTERUS CONTRACTILITY; UTERUS CONTRACTION;

EID: 0034113901     PISSN: 00029378     EISSN: None     Source Type: Journal    
DOI: 10.1067/mob.2000.104202     Document Type: Article

References (19)

1. 1. Seamon KB, Padgett W, Daly JW. Forskolin: unique diterpene activator of adenylate cyclase in membranes and in intact cells. Proc Natl Acad Sci U S A 1981;78:3363-7.
2. 2. Schmidt K, Kukowetz WR. Mediation of the cardiac effects of forskolin by specific binding sites. J Cardiovasc Pharmacol 1989;13:353-60.
3. 3. Marshall JM, Fain JN. Effects of forskolin and isoproterenol on cyclic AMP and tension in the myometrium. Eur J Pharmacol 1984;107:25-34.
4. 4. Wagoner PK, Pallotta BS. Modulation of acetylcholine receptor desensitization by forskolin is independent of cAMP. Science 1988;40:1655-587.
5. 5. Uoshi T, Garber SS, Aldrich RW. Effect of forskolin on voltage-gated K+ channels is independent of adenylate cyclase. Sciences 1988;249:1652-5.
6. 6. Castle NA. Inhibition of voltage-dependent NA+ and K+ currents by forskolin in node of Ranvier. Pflugers Arch 1989;415:322-9.
7. 7. Harris-Warrick RM. Forskolin reduces a transient potassium current in lobster neurons by a cAMP-independent mechanism. Brain Res 1989;489:59-66.
8. 8. Galitta LJ, Rasola A, Barone V, Gruenert DC, Romeo G. A forskolin and verapamil sensitive K+ current in human tracheal cells. Biochem Biophys Res Commun 1991;179:1155-60.
9. 9. Hiramatsu T, Kume H, Kotlikoff MI, Takagi K. Role of calcium-activated potassium channels in the relaxation of tracheal smooth muscle by forskolin. Clin Exp Pharmacol Physiol 1994;21:367-75.
10. 10. Minami K, Fukuzawa K, Nakaya Y, Zeng XR, Inoue I. Mechanism of activation of the Ca (2+)-activated K+ channel by cyclic AMP in cultured porcine coronary artery smooth muscle cells. Life Sci 1993;53:1129-35.
11. 11. Xakashgima M, Vanhoutte PM. Isoproterenol causes hyperpolarization through opening of ATP-sensitive channels in vascular smooth muscle of the canine saphenous vein. J Pharmacol Exp Ther 1955;272:379-84.
12. 12. Ahn DS, Jeong YK, Lee YH, Kang BS. Activation of Ca(2+)activated K+ channels by beta agonist in rabbit coronary smooth muscle. Yonsei Med J 1955;36:232-42.
13. 13. Sadoshima J, Sakaike N, Kanaide H, Nakamura M. Cyclic AMP modulates Ca-activated K channel in cultured smooth muscle cells of rat aorta. Am J Physiol 1988;255:H754-9.
14. 14. Sheridan BC, McIntyre RC, Meldrum DR, Fullerton DA. KATP channels contribute to beta-one adenosine receptor-mediated pulmonary vasorelaxation. Am J Physiol 1997;273:L950-6.
15. 15. Rembold CM, Chen XL. Mechanism responsible for forskolin-induced relaxation of rat tail artery. Hypertension 1998;31:872-7.
16. 10. Onoue H, Katusik ZS. The effect of subarachnoid hemorrhage on mechanism of vasodilation mediated by cyclic adenosine monophosphate. J Neurosurg 1988;89:111-7.
17. 17. Tritthart HA, Mahnert W, Fleischhacker A, Adelwohrer N. Potassium channels and modulating factors of channel functions in the human myometrium. Z Kardiol 1991;80:29-33.
18. 18. Inoue Y, Shimamura K, Sperelakis N. Forskolin inhibition of K+ current in pregnant rat uterine smooth muscle cells. Eur J Pharmacol 1993;240:169-76.
19. 19. Okawa T, Longo M, Vedernikov Y, Saade G, Chwalizs K, Garfield R. Role of nucleitide cyclases in the inhibition of uterine contractions by K-channel openers in pregnant rats [abstract]. J Soc Gynecol Investig 1998;5:187A.