The physics of powder flow: Applied to pharmaceutical solids

Pharmaceutical Technology

Volumn 24, Issue 2, 2000, Pages 50-58

  Crowder, Timothy M ^a   Hickey, Anthony J ^b  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b NORTH CAROLINA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; DRUG GRANULE; DRUG MANUFACTURE; DYNAMICS; PHYSICS; POWDER; SOLID STATE; VIBRATION;

EID: 0034113796     PISSN: 01478087     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. B.H. Kaye, A Random Walk through Fractal Dimensions (VCH Publishers, New York, 1989).
2. A.J. Hickey and N.M. Concessio, "Flow Properties of Selected Pharmaceutical Powders from a Vibrating Spatula," Part. Part. Syst. Charact. 11, 457-462 (1994).
3. B.H. Kaye, J. Gratton-Liimatainen, and N. Faddis, "Studying the Avalanching Behaviour of a Powder in a Rotating Disc," Part. Part. Syst. Charact. 12, 232-236 (1995).
4. A.J. Hickey and N.M. Concessio, "Chaos in Rotating Lactose Powder Beds," Part. Sci. Tech. 14, 15-25 (1996).
5. H.M. Jaeger, S.R. Nagel, and R.P. Behringer, "The Physics of Granular Materials," Phys. Today 49, 32-38 (1996).
6. L. Trowbridge et al., "A Comparison of Methods for Determining Powder Flow: Correla-tion with Tableting Performance," Pharm. Res. 14, 5-415 (1997).
7. J.C. Feeley et al., "Determination of Surface Properties and Flow Characteristics of Salbutamol Sulfate before and after Micronization," Int. J. Pharm.172, 89-96 (1998).
8. E. Morales-Gamboa et al., "Two-Dimensional Avalanches as Stochastic Markov Processes," Phys. Rev. E: Stat. Phys., Plasmas, Fluids, Relat. Interdiscip. Top. 47, R2229-R2232 (1993).
9. G. Baumann, I.M. Jánosi, and D.E. Wolf, "Surface Properties and Flow of Granular Material in a Two-Dimensional Rotating-Drum Model," Phys. Rev. E: Stat. Phys., Plasmas, Fluids, Relat. Interdiscip. Top. 51, 1879-1888 (1995).
10. G. Metcalfe et al., "Avalanche Mixing of Granular Solids," Nature 374, 39-41 (1995).
11. A. Castellanos et al., "Flow Regimes in Fine Cohesive Powders," Phys. Rev. Lett. 82, 1156-1159 (1999).
12. P. Evesque, "Analysis of the Statistics of Sand-Pile Avalanches Using Soil-Mechanics Results and Concepts," Phys. Rev. A: At., Mol., Opt. Phys. 43, 2720-2740 (1991).
13. A. Martin, Physical Pharmacy (Lea & Febiger, Philadelphia, PA, 1993).
14. A.J. Hickey et al.,"Factors Influencing the Dispersion of Dry Powders as Aerosols," Pharm. Technol. 18 (8), 58-64 (1994).
15. D. Schulze, "Storage, Feeding, and Proportioning," in Handbook of Powder Technology, Vol 9, D. Chulia, M. Delevil, and Y. Pourcelot, Eds. (Elsevier Science Publishing Co., Inc., New York, 1994), pp. 285-318.
16. K. Liffman, G. Metcalfe, and P. Cleary, "Convection due to Horizontal Shaking," in Powders and Grains '97, R. Behringer and J. T. Jenkins, Eds. (A. A. Balkema, Brookfield, VT, 1997), pp. 405-408.
17. G. Barker and M. Grimson, "The Physics of Muesli," New Scientist 126, 37-40 (26 May 1990).
18. T. Higuchi, "Approach to an Irregular Time Series on the Basis of the Fractal Theory," Physica D 31, 277-283 (1988).
19. T.M. Crowder and A.J. Hickey, "An Instrument for Rapid Powder Flow Measurement and Temporal Fractal Analysis," Part. Part. Sys. Charact. 16, 32-34 (1999).
20. H.M. Jaeger, C.-H. Liu, and S.R. Nagel, "Relaxation at the Angle of Repose," Phys. Rev. Lett. 62, 40-43 (1989).
21. P. Bak, C. Tang, and K. Wisenfeld, "Self-Organized Criticality: An Explanation of 1/f Noise," Phys. Rev. Lett. 59, 381-384 (1987).
22. G. Baumann and D.E. Wolf, "Self-Organized Criticality in a Two-Dimensional Rotating Drum Model," Phys. Rev. E: Stat. Phys., Plasmas, Fluids, Relat. Interdiscip. Top. 54, R4504-R4507 (1996).
23. N.M. Concessio, "Dynamic Properties of Pharmaceutical Powders and Their Impact on Aerosol Dispersion," doctoral dissertation (Division of Pharmaceutics, University of North Carolina at Chapel Hill, Chapel Hill, NC, 1997).
24. T.M. Crowder et al., "Signal Processing and Analysis Applied to Powder Behavior in a Rotating Drum," Part. Part. Sys. Charact. 16 (4), 191-196 (1999).
25. M. Poux et al., "Powder Mixing - Some Practical Rules Applied to Agitated Systems," Powder Technol 68, 213-234 (1991).
26. D.V. Khakhar et al., "Chaotic Mixing of Granular Materials in Two-Dimensional Tumbling Mixers," Chaos 9, 195-205 (1999).
27. H. Henein, J.K. Brimacombe, and A.P. Watkinson, "Experimental Study of Transverse Bed Motion in Rotary Kilns," Metall. Mater. Trans. B 14, 191-197 (1983).
28. M. Nakagawa et al., "NMR Measurement and Approximate Derivation of the Velocity Depth Profile of Granular Flow in a Rotating, Partially Filled, Horizontal Cylinder," in Powders and Grains '97, R. Behringer and J. Jenkins, Eds. (A. A. Balkema, Brookfield, VT, 1997), pp. 447-450.
29. S.N. Dorogovtsev, "Avalanche Mixing of Granular Materials: Time Taken for the Disappearance of the Pure Fraction," Tech. Phys. 42, 1346-1348 (1997).
30. C. Caravati et al., "Hyperchaotic Qualities of the Ball Motion in a Ball Milling Device," Chaos 9, 219-226 (1999).
31. E. Ott, C. Grebogi, and J. A. Yorke, "Controlling Chaos," Phys. Rev. Lett. 64, 1196-1199 (1990).
32. J. Gleick, Chaos: Making a New Science (Viking, New York, 1987).