Detection of cocaine metabolite in serum and urine: frequency and correlation with medical diagnosis

Clinica Chimica Acta

Volumn 295, Issue 1-2, 2000, Pages 179-185

  Linder, Mark W ^a   Bosse, George M ^a   Henderson, Mark T ^a   Midkiff, Gerald ^a   Valdes Jr , Roland ^a  

^a University of Louisville School of Medicine   (United States)

Author keywords

Benzyolecgonine; Cocaine; Drugs of abuse testing; Immunoassay; Liquid chromatography

Indexed keywords

BENZOYLECGONINE; COCAINE; DRUG METABOLITE;

ARTICLE; BLOOD ANALYSIS; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DRUG ABUSE; GAS CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; IMMUNOASSAY; INTERMETHOD COMPARISON; INTOXICATION; MASS SPECTROMETRY; PRIORITY JOURNAL; SCREENING TEST; TOXICOLOGY; URINALYSIS;

COCAINE; COCAINE-RELATED DISORDERS; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HALF-LIFE; HUMANS; MEDICAL AUDIT; RETROSPECTIVE STUDIES; SENSITIVITY AND SPECIFICITY;

EID: 0034112943     PISSN: 00098981     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0009-8981(99)00249-1     Document Type: Article

References (10)

1. Helper B., Sutheimer C., Sunshine I. Role of the toxicology laboratory in suspected ingestions. Pediatr Toxicol. 33:1986;245-260.
2. Ross E.M. Pharmacodynamics: mechanisms of drug action and the relationship between drug concentration and effect. Hardman J.G., Limbird L.E. Goodman & Gilman's the pharmacological basis of therapeutics. 9th edition :1996;29-30 McGraw-Hill, New York.
3. Vernon D.D., Gleich M.C. Poisoning and drug overdose. Crit Care Clinics. 13:1997;647-667.
4. Brett A.S. Implications of discordance between clinical impression and toxicology analysis in drug overdose. Arch Intern Med. 148:1988;437.
5. Helper B.R., Sutheimer C.A., Sunshine I. The role of the toxicology laboratory in emergency medicine II. Study of an integrated approach. Clin Toxicol. 22:1985;503-528.
6. Kageura M., Hara K., Kashimura S., et al. Remedi HS for screening of drugs and poisons: comparison with GC/MS. Jpn J Forensic Toxicol. 12:1994;207-212.
7. Sadeg N., Francois G., Petit B., et al. Automated liquid-chromatographic analyzer used for toxicology screening in a general hospital: 12 months' experience. Clin Chem. 43:1997;498-504.
8. Baselt R.C. Analytical procedures for therapeutic drug monitoring and emergency toxicology. 2nd edition :1987;92-97 PSG, Littleton, MA.
9. Cone E.J. Pharmacokinetics and pharmacodynamics of cocaine. J Anal Toxicol. 19:1995;459-478.
10. Poklis A., Jortani S., Edinboro L.E., Saady J. Direct determination of benzoylecgonine in serum by EMIT d.a.u. cocaine metabolite immunoassay. J Anal Toxicol. 18:1994;419-422.