Neuromuscular function of the human lower oesophageal sphincter in reflux disease and Barrett's oesophagus

Gut

Volumn 46, Issue 6, 2000, Pages 756-761

  Smid, S D ^a   Blackshaw, L A ^a  

^a ROYAL ADELAIDE HOSPITAL   (Australia)

Author keywords

Barrett's oesophagus; Inhibitory motorneurones; Lower oesophageal sphincter; Smooth muscle; Tachykinins; Tetrodotoxin

Indexed keywords

1,1 DIMETHYL 4 PHENYLPIPERAZINIUM; BETHANECHOL; CAPSAICIN; ISOPRENALINE; POTASSIUM CHLORIDE; TACHYKININ; TETRODOTOXIN;

ADULT; AGED; ARTICLE; BARRETT ESOPHAGUS; CHOLINERGIC TRANSMISSION; CLINICAL ARTICLE; ELECTROSTIMULATION; GASTROESOPHAGEAL REFLUX; HUMAN; HUMAN TISSUE; LOWER ESOPHAGUS SPHINCTER; MOTONEURON; MUSCLE RELAXATION; MUSCLE TONE; NEUROMUSCULAR FUNCTION; PRIORITY JOURNAL; SMOOTH MUSCLE;

BARRETT ESOPHAGUS; CARCINOMA, SQUAMOUS CELL; DOSE-RESPONSE RELATIONSHIP, DRUG; ESOPHAGOGASTRIC JUNCTION; GASTROESOPHAGEAL REFLUX; HUMANS; MUSCLE CONTRACTION; MUSCLE RELAXATION; NEUROMUSCULAR AGENTS; NEUROMUSCULAR JUNCTION;

EID: 0034111132     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.46.6.756     Document Type: Article

References (31)

1. 1 Riddell RH. Early detection of neoplasia of the esophagus and gastroesophageal junction. Am J Gastroenterol 1996;91:853-63.
2. 2 Lidums I, Holloway R. Motility abnormalities in the columnar-lined esophagus. Gastroenterol Clin N Am 1997; 26:519-31.
3. 3 Niemantsverdriet EC, Timmer R, Breumelhof R, et al. The roles of excessive gastro-esophageal reflux, disordered oesophageal motility and decreased mucosal sensitivity in the pathogenesis of Barrett's oesophagus. Eur J Gastroenterol Hepatol 1997;9:515-19.
4. 4 Rakic S, Stein HJ, DeMeester TR, et al. Role of esophageal body function in gastroesophageal reflux disease-implications for surgical management. J Am Coll Surg 1997;185:380-7.
5. 5 Stein HJ, Hoeft SH, DeMeester TR. Functional foregut abnormalities in Barrett's oesophagus. J Thorac Cardiovasc Surg 1993;105:107-11.
6. 6 Trimble KC, Pryde A, Heading RC. Lowered oesophageal sensory thresholds in patients with symptomatic but not excess gastro-esophageal reflux: evidence for a spectrum of visceral sensitivity in GORD. Gut 1995;37:7-12.
7. 7 Goldstein SR, Yang G-Y, Curtis SK, et al. Development of esophageal metaplasia and adenocarcinoma in a rat surgical model without the use of a carcinogen. Carcinogenesis 1997;18:2265-70.
8. 8 Li H, Walsh TN, O'Dowd G, et al. Mechanisms of columnar metaplasia and squamous regeneration in experimental Barrett's esophagus. Surgery 1994;115:176-81.
9. 9 Smid SD, Page AJ, O'Donnell T, et al. Oesophagitis-induced changes in capsaicin-sensitive tachykininergic pathways in the ferret lower oesophageal sphincter. Neurogastroenterol Motil 1998;10:403-11.
10. 10 Biancani P, Billett G, Hillemeier C, et al. Acute experimental esophagitis impairs signal transduction in cat lower esophageal sphincter circular muscle. Gastroenterology 1992;103:1199-206.
11. 11 Prieksaitis HG, Diamant NE. Regional differences in cholinergic activity of muscle fibres from the human gastroesophageal junction. Am J Physiol 1997;272:G1321-7.
12. 12 Liebermann-Meffert D, Allgower M, Schmid P, et al. Muscular equivalent of the lower esophageal sphincter. Gastroenterology 1979;76:31-8.
13. 13 Stein HJ, Liebermann-Meffert D, DeMeester TM, et al. Three-dimensional pressure image and muscular structure of the human lower esophageal sphincter. Surgery 1995; 117:692-8.
14. 14 Tottrup A, Forman A, Uldbjerg N, et al. Mechanical properties of isolated human esophageal smooth muscle. Am J Physiol 1990;258(3 Pt 1):G338-43.
15. 15 Beveridge AA, Taylor GS. Evidence for a lower oesophageal sphincter in the guinea-pig. Comp Biochem Physiol 1989; 93C:293-301.
16. 16 Allescher HD, Berezin I, Jury J, et al. Characteristics of canine lower esophageal sphincter: a new electrophysiological tool. Am J Physiol 1988;255(4 Pt 1):G441-53.
17. 17 Kortezova N, Velkova V, Mizhorkova Z, et al. Participation of nitric oxide in the nicotine-induced relaxation of the cat lower oesophageal sphincter. J Auton Nerv Syst 1994;50: 73-8.
18. 18 Tottrup A, Ny L, Alm P, et al. The role of the L-arginine/nitric oxide pathway for relaxation of the human lower oesophageal sphincter. Acta Physiol Scand 1993;149: 451-9.
19. 19 Huber O, Bertrand C, Bunnett NW, et al. Tachykinins mediate contraction of the human lower esophageal sphincter in vitro via activation of NK-2 receptors. Eur J Pharmacol 1993;239:103-9.
20. 20 Sohn UD, Harnett KM, Cao W, et al. Acute experimental oesophagitis activates a second signal transduction pathway in cat smooth muscle from the lower oesophageal sphincter. J Pharm Exp Ther 1997;283:1293-304.
21. 21 Biancani P, Harnett KM, Sohn UD, et al. Differential signal transduction pathways in cat lower esophageal sphincter tone and response to ACh. Am J Physiol 1994;266(5 Pt 1):G767-74.
22. 22 Guard S, Watson SP. Tachykinin receptor types: classification and membrane signalling mechanisms. Neurochem Int 1991;18:149-65.
23. 23 Preiksaitis HG, Tremblay L, Diamant NE. Cholinergic responses in the cat lower esophageal sphincter show regional variation. Gastroenterology 1994;106:381-8.
24. 24 Dodds W, Dent J, Hogan W, et al. Effect of atropine on the gastroesophageal sphincter. Am J Physiol 1981;240:G290-6.
25. 25 Richardson BJ, Welch RW. Differential effect of atropine on rightward and leftward lower oesophageal sphincter pressure. Gastroenterology 1981;81:85-9.
26. 26 Lidums I, Checklin H, Mittal RK, et al. Effect of atropine on gastro-oesophageal reflux and transient lower oesophageal relaxations in patients with gastro-oesophageal reflux disease. Gut 1998;43:12-16.
27. 27 Tottrup A, Forman A, Madsen G, et al. The actions of some beta-receptor agonists and xanthines on isolated muscle strips of the human lower oesophageal sphincter. Pharmacol Toxicol 1990;67:340-3.
28. 28 Smid SD, Lynn PA, Templeman R, et al. Activation of non-adrenergic non-cholinergic inhibitory pathways by endogenous and exogenous tachykinins in the ferret lower oesophageal sphincter. Neurogastroenterol Motil 1998;10: 149-56.
29. 29 Akopian AN, Sivilotti L, Wood JN. A tetrodotoxin-resistant voltage-gated sodium channel expressed by sensory neurons. Nature 1996;379:257-62.
30. 30 Tanaka M, Cummins TR, Ishikawa K, et al. SNS Na+ channel expression increases in dorsal root ganglion neurons in the carrageenan inflammatory pain model. Neuroreport 1998;9:967-72.
31. 31 Triadafilopoulos G, Kaczynska M, Iwane M. Esophageal mucosal eicosanoids in gastroesophageal reflux disease and Barrett's esophagus. Am J Gastroenterol 1996;91:65-74.