Nucleated RBCs - Significance in the peripheral blood film

Laboratory Medicine

Volumn 31, Issue 4, 2000, Pages 223-229

  Constantino, Benie T ^a   Cogionis, Bessie ^b  

^a CENTRE FOR ADDICTION AND MENTAL HEALTH   (Canada)

^b HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANEMIA; BONE MARROW DISEASE; CALCULATION; CELL NUCLEUS; DIAGNOSTIC ACCURACY; ERYTHROBLASTOPENIA; ERYTHROCYTE STRUCTURE; ERYTHROPOIESIS; EXTRAMEDULLARY HEMATOPOIESIS; HUMAN; HYPOXIA; LABORATORY AUTOMATION; LEUKOCYTE COUNT; REVIEW; SPLEEN DISEASE; STRESS;

EID: 0034110989     PISSN: 00075027     EISSN: None     Source Type: Journal    
DOI: 10.1309/D70F-HCC1-XX1T-4ETE     Document Type: Review

References (38)

1. Miller DR, Baehner RL. Blood Diseases of Infancy and Childhood. 7th ed. St Louis, MO: Mosby; 1995:39-40.
2. Green DW, Mimouni F. Nucleated erythrocytes in healthy infants and in infants of diabetic mothers. J Pediatr. 1990;116:129-131.
3. Crosby WH. Hyposplenism: an inquiry into the normal function of the spleen. Annu Rev Med. 1963;14:349-370.
4. Hanlon-Lundberg KM, Kirby RS. Nucleated red blood cells as a marker of acidemia in neonates. Am J Obstet Gynecol. 1999;181:196-201.
5. Sills RH, Hadley RAR. The significance of nucleated red blood cells in the peripheral blood of children. Am J Pediatr Hematol Oncol. 1983;5:173-177.
6. Schwartz SO, Stanbury F. Significance of nucleated red blood cells in peripheral blood: analysis of 1496 cases. JAMA. 1954;154:1339-1340.
7. LeBlond P, LaCelle P, Weed RI. Cellular deformity: a possible determinant of normal marrow release of maturing erythrocytes from the bone marrow. Blood. 1971;37:40-46.
8. Laboratory Proficiency Testing Program. Hematology-Morphology Survey Report: March 1987-July 1999. Ontario, Canada: Ontario Medical Association; 1999:3-99.
9. Lee RG, Bitchell TC, Foerster J, et al, eds. In: Wintrobe's Clinical Hematology. 9th ed. Philadelphia, PA: Lea & Febiger; 1993:316-317.
10. Sills RH. Hyposplenism. In: Pochedly C, Sills RH, Schwartz AD, eds. Disorders of the Spleen Pathophysiology and Management. New York, NY: Marcel Dekker; 1989:99-133.
11. Dacie JV, Lewis SM. Practical Hematology. 8th ed. New York, NY: Churchill Livingstone; 1995:115-116.
12. Delamore LW, Liu Yen JA, eds. Haematological Aspects of Systemic Disease. London, England: Boilliere Tindall; 1990:280.
13. Alter BP, Young NS. The bone marrow failure syndromes. In: Nathan DG, Oski FO, eds. Hematology of Infancy and Childhood. 5th ed. Philadelphia, PA: Saunders; 1998:309-311.
14. Erslev AJ. Anemia associated with marrow infiltration. In: Beutler E, Lichtman MA, Coller BS, et al, eds. Williams Hematology. 5th ed. New York, NY: McGraw-Hill; 1995:516-518.
15. Custer RP. An Atlas of the Blood and Bone Marrow. 2nd ed. Philadelphia, PA: Saunders; 1974:22-25, 123-136.
16. Clifford GO. The clinical significance of leukoerythroblastic anemia. Med Clin North Am. 1966;50:779-790.
17. Relief FP. Leukoerythroblastosis in the adult. Lancet. 1964;1:639-642.
18. Weick JK, Hagedorn AB, Linman JW. Leukoerythroblastosis: diagnostic and prognostic significance. Mayo Clin Proc. 1974;49:110-113.
19. Andes WB. Normoblastemia after thermal injury. Am J Surg. 1976;131:725-726.
20. Porth CM, ed. Pathophysiology Concepts of Altered Health States. 5th ed. Philadelphia, PA: Lippincott-Raven; 1998:134-135.
21. Bennett JC, Plum F, eds. Cecil Textbook of Medicine. 20th ed. Philadelphia, PA: Saunders; 1996:453, 466-469.
22. Fauci AS, Braunwald E, eds. Harrison's Principles of Internal Medicine. 14th ed. New York, NY: McGraw-Hill; 1998:205-209.
23. Ward HP, Holman J. The association of nucleated red cells in the peripheral smear with hypoxemia. Ann Intern Med. 1967;67:1190-1194.
24. Frumin AM, Mendel TH, Mintz SS, et al. Nucleated red blood cells in congestive heart failure. Circulation. 1959;20:367-370.
25. Wang JC, Cheung CP, Ahmed F, et al. Circulating granulocyte and macrophage progenitor cells in primary and secondary myelofibrosis. Br J Haematol. 1983;54:301-307.
26. Stiene-Martin EA, Lotspeich-Steininger CA, Koepke JA, eds. Clinical Hematology Principles, Procedures, Correlations. 2nd ed. Philadelphia, PA: Lippincott-Raven; 1998:93, 339-340, 463-465.
27. Schmitz LL, McClure JS, Litz LE, et al. Morphologic and quantitative changes in blood and marrow cells following growth factor therapy. Am J Clin Pathol. 1994;101:67-75.
28. Arici M, Haznedaroglu IC, Erman M, et al. Leukoerythroblastosis following the use of G-CSF. Am J Histol. 1996;52:122-123.
29. Rodgers MS, Chang C, Kass L. Elliptocytes and tailed poikilocytes correlate with severity of iron-deficiency anemia. Am J Clin Pathol. 1999;111:672-675.
30. Bessis M. Blood Smears Reinterpreted. Paris, France: Springer International; 1977:74.
31. Cornbleet PJ, Myriel D, Levy R. Evaluation of the Coulter STKS five-part differential. Am J Clin Pathol. 1993;99:72-81.
32. Cornbleet PJ, Myrick D, Judkins S, et al. Evaluation of the Cell-Dyn 3000 differential. Am J Clin Pathol. 1992;98:603-614.
33. R 4000 hematology analyzer, and microscopy. Lab Hematol. 1998;4:64-70.
34. Kim YR, Yee M, Metha S, et al. Simultaneous differentiation and quantitation of erythroblasts and white blood cells on a high throughput clinical haematology analyzer. Clin Lab Haematol. 1998;20:21-29.
35. Simmons A. Hematology: A Combined Theoretical and Technical Approach. Philadelphia, PA: Saunders; 1989:192.
36. Seiverd CE. Hematology for Medical Technologists. 5th ed. Philadelphia, PA: Lea & Febiger; 1983:143-144.
37. Frankel S, Reitman S, Sonnenwirth AC, eds. Gradwohl's Clinical Laboratory Methods and Diagnosis. 6th ed. St Louis, MO: Mosby; 1970:501.
38. Medical News: Nucleated RBCs in blood of adults should be cause for concern. JAMA. 1978;239:91.