In Vitro erythrocidal activity of activated spleen cells from young and old mice

Experimental Gerontology

Volumn 35, Issue 3, 2000, Pages 409-416

  Saxena, Rajiv K ^a,b   Adler, William H ^a,b  

^a JAWAHARLAL NEHRU UNIVERSITY   (India)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

Aging; Cytotoxicity; Erythrocytes; Fas; Phagocytosis

Indexed keywords

FAS ANTIGEN; MONOCLONAL ANTIBODY;

AGING; ANIMAL CELL; ARTICLE; CELL CULTURE; CELL KINETICS; CELL LOSS; CYTOTOXICITY; ERYTHROCYTE; HEMOLYSIS; LYMPHOCYTE DEPLETION; MALE; MONONUCLEAR CELL; MOUSE; NONHUMAN; OPSONIZATION; PHAGOCYTOSIS; PRIORITY JOURNAL; SPLEEN CELL;

AGING; ANIMALS; ANTIBODIES, MONOCLONAL; CELL SURVIVAL; CONCANAVALIN A; CRICETINAE; CYTOTOXICITY, IMMUNOLOGIC; ERYTHROCYTES; KINETICS; LEUKOCYTES, MONONUCLEAR; MACROPHAGES; MALE; MICE; MICE, INBRED C57BL; OPSONIN PROTEINS; SPLEEN;

ANIMALIA; CRICETINAE;

EID: 0034110087     PISSN: 05315565     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0531-5565(00)00091-7     Document Type: Article

References (22)

1. Baerlocher G.M., Schlappritzi E., Tobler A., Reinhart W.H. The influence of tumour necrosis factor-alpha on phagocytosis of human erythrocytes by autologous monocytes/macrophages. Eur J Haematol. 58:1997;357-359.
2. Bocci V. Determinants of erythrocyte aging a reappraisal . Brit J Haematol. 48:1981;515-522.
3. Bratosin D., Mazurier J., Tissier J.P., Estaquier J., Huart J.J., Ameisen J.C., Aminoff D., Montreuil J. Cellular and molecular mechanisms of senescent erythrocyte phagocytosis by macrophages. A review. Biochimie. 80:1998;173-195.
4. Engwerda C.R., Handwerger B.S., Fox B.S. Aged T cells are hyporesponsive to costimulation mediated by CD28. J Immunol. 152:1994;3740-3747.
5. Ernst D.N., Wigle W.O., Noonan D.N., McQuitty D.N., Hobbs M.V. The age-associated increase in IFN-gamma synthesis by mouse CD8+ T cells correlates with shifts in the frequencies of cell subsets defined by membrane CD44, CD45RB, 3G11, and MEL-14 expression. J Immunol. 151:1993;575-587.
6. Gershon H., Sheiben E. In vitro sequestration of erythrocytes from hosts of various ages. Adv Exp. Med Biol 307:1991;339-350.
7. Hirano T., Nordin A.A. Age-associated decline in the in vitro development of cytotoxic lymphocytes in NZB mice. J Immunol. 117:1976;1093-1098.
8. Landaw S.A. Factors that accelerate or retard red blood cell senescence. Blood cells. 14:1988;47-67.
9. Lerner A., Yamada T., Miller R.A. Pgp-1hi T lymphocytes accumulate with age in mice and respond poorly to concanavalin A. Eur J Immunol. 19:1989;977-982.
10. Mbawuike I.N., Acuna C.L., Walz K.C., Atmar R.L., Greenberg S.B., Couch R.B. Cytokines and impaired CD8+ CTL activity among elderly persons and the enhancing effect of IL-12. Mech Ageing Dev. 94:1997;25-39.
11. hi CD4+ T cells. Eur J Immunol. 21:1991;273-281.
12. Powers D.C., Belshe R.B. Effect of age on cytotoxic T lymphocyte memory as well as serum and local antibody responses elicited by inactivated influenza virus vaccine. J Infect Dis. 167:1993;584-592.
13. Saxena, R. K. (2000). Should erythrocyte destruction in vivo be through phagocytosis alone? J Biosciences. In press.
14. Saxena R.K., Adler W.H. Cytolytic activity of mitogen activated old and young mouse spleen cells against tumor target cells expressing high or low levels of Fas antigen. Exp Mol Med. 31:1999;137-141.
15. Saxena, R. K., Adler, W. H., & Nordin, A. A. (1981). Modulation of natural cytotoxicity by alloantibodies. IV. A comparative study of the activation of mouse spleen cell cytotoxicity by anti H-2 antisera, interferon, and mitogens. Cellular Immunol 63, 28-40.
16. Saxena, R. K. & Chandrasekhar, B. (2000). A novel non-phagocytic mechanism of erythrocyte destruction involving direct cell mediated cytotoxicity. Int J Hematology. In press.
17. Saxena R.K., Saxena Q.B., Adler W.H. Interleukin-2-induced activation of natural killer activity in spleen cells from old and young mice. Immunology. 51:1984;719-726.
18. Saxena R.K., Saxena Q.B., Adler W.H. Lectin-induced cytotoxic activity in spleen cells from young and old mice. Age-related changes in types of effector cells, lymphokine production and response. Immunology. 64:1988;457-461.
19. Shimizu K., Hokano M. Elimination of old or worn red blood cells in the senile murine spleen. Acta Histochem. 83:1988;65-70.
20. Smith L.A. Autoimmune hemolytic anemias characteristics and classification . Clin Lab Sci. 12:1999;110-114.
21. Song, L., Kim, Y. H., Chopra, J. J., Proust, J. J., Nagel, J. E., Nordin, A. A., & Adler W. H. (1993). Age-related effects in T cell activation and proliferation. Exp Gerontol 28, 313-321.
22. Taverne J., Sheikh N., de Souza J.B., Playfair J.H., Probert L., Kollias G. Anemia and resistance to malaria in transgeneic mice expressing human tumor Necrosis Factor. Immunology. 82:1994;397-403.