Binding to cysteinyl-leukotriene receptors

American Journal of Respiratory and Critical Care Medicine

Volumn 161, Issue 2 II, 2000, Pages

  Nicosia, Simonetta ^a   Capra, Valérie ^a   Ravasi, Saula ^a   Rovati, G Enrico ^a  

^a UNIVERSITY OF MILAN   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

1 [2 METHOXY 4 [(PHENYLSULFONYLAMINO)CARBONYL]BENZYL] 1H INDAZOLE 6 CARBAMIC ACID CYCLOPENTYL ESTER; 5 (3 CARBOXYBENZOYL) 2 [6 (4 METHOXYPHENYL) 5 HEXENYLOXY]HYDROCINNAMIC ACID; 5 ETHYL 2 HYDROXY 4 [6 METHYL 6 (1H TETRAZOL 5 YL)HEPTYLOXY]ACETOPHENONE; 5 [2 (2 CARBOXYETHYL) 3 [6 (4 METHOXYPHENYL) 5 HEXENYLOXY]PHENOXY]VALERIC ACID; 5 [5 (4,6 DIPHENYL 2 PYRIDYLOXY) 1,1 DIMETHYLPENTYL]TETRAZOLE; 6 (4 CARBOXYPHENYLTHIO) 5 HYDROXY 7,9,11,14 ICOSATETRAENOIC ACID; 7 [3 (4 ACETYL 3 HYDROXY 2 PROPYLPHENOXY) 2 HYDROXYPROPOXY] 4 OXO 8 PROPYL 4H 1 BENZOPYRAN 2 CARBOXYLIC ACID; 7 [3 (4 ACETYL 3 METHOXY 2 PROPYLPHENOXY)PROPOXY] 3,4 DIHYDRO 8 PROPYL 2H 1 BENZOPYRAN 2 CARBOXYLIC ACID; IRALUKAST; LEUKOTRIENE B4; LEUKOTRIENE C4; LEUKOTRIENE D4; LEUKOTRIENE RECEPTOR; LEUKOTRIENE RECEPTOR BLOCKING AGENT; MONTELUKAST; PEPTIDOLEUKOTRIENE; POBILUKAST; PRANLUKAST; RG 14893; SB 201993; SLOW REACTING SUBSTANCE; UNCLASSIFIED DRUG; VERLUKAST; ZAFIRLUKAST;

AIRWAY; ANIMAL TISSUE; ASTHMA; BRONCHOSPASM; CLASSIFICATION; GUINEA PIG; HUMAN; HUMAN TISSUE; INFLAMMATION; NOMENCLATURE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; RECEPTOR BINDING; RECEPTOR BLOCKING; RECEPTOR DENSITY; REVIEW;

EID: 0034108183     PISSN: 1073449X     EISSN: None     Source Type: Journal    
DOI: 10.1164/ajrccm.161.supplement_1.ltta-10     Document Type: Review

References (57)

1. 4 that mediates chemotaxis. Nature (London) 387:620-624.
2. Augstein, J., J. B. Farmer, T. B. Lee, P. Sheard, and M. L. Tattersall. 1973. Selective inhibitor of slow reacting substance of anaphylaxis. Nature New Biol. 245:215-217.
3. Lewis, R. A., J. M. Drazen, K. F. Austen, M. Toda, F. Brion, A. Marfat, and E. J. Corey. 1981. Contractile activities of structural analogs of leukotrienes C and D: role of the polar substituents. Proc. Natl. Acad. Sci. U.S.A. 78:4579-4583.
4. Drazen, J. M., R. A. Lewis, K. F. Austen, M. Toda, F. Brion, A. Marfat, and E. J. Corey. 1981. Contractile activities of structural analogs of leukotrienes C and D: necessity of hydrophobic region. Proc. Natl. Acad. Sci. U.S.A. 78:3195-3198.
5. Salmon, J. A., and L. G. Garland. 1991. Leukotriene antagonists and inhibitors of leukotriene biosynthesis as potential therapeutic agents. Prog. Drug Res. 37:9-90.
6. Hay, D. W. P., T. J. Torphy, and B. J. Undem. 1995. Cysteinyl leukotrienes in asthma: old mediators up to new tricks. Trends Pharmacol. Sci. 16:304-309.
7. Barnes, P. J. 1992. Frontiers in medicine, new aspects of asthma. J. Intern. Med. 231:453-161.
8. Coleman, R. A., R. M. Eglen, R. L. Jones, S. Narumiya, T. Shimizu, W. L. Smith, S. E. Dahlén, J. M. Drazen, P. J. Gardiner, W. T. Jackson, T. R. Jones, R. D. Krell, and S. Nicosia. 1995. Prostanoid and leukotriene receptors: a progress report from the IUPHAR Working Parties on Classification and Nomenclature. In B. Samuelsson, P. W. Ramwell, R. Paoletti, G. Folco, E. Granström, and S. Nicosia, editors. Advances in Prostaglandin, Thromboxane and Leukotriene Research. Raven Press, New York. 283-285.
9. Spector, S. L. 1997. Leukotriene activity modulation in asthma. Drugs 54:369-384.
10. 4 antagonist in the guinea pig trachea. Ann. N.Y. Acad. Sci. 629:402-404.
11. Rovati, G. E., V. Capra, and S. Nicosia. 1997. More on the classification of cysteinyl leukotriene receptors. Trends Pharmacol. Sci. 18:148.
12. Capra, V., S. Nicosia, D. Ragnini, M. Mezzetti, D. Keppler, and G. E. Rovati. 1998. Identification and characterization of two Cys-leukotriene high-affinity binding sites with receptor characteristics in human lung parenchyma. Mol. Pharmacol. 53:750-758.
13. Labat, C., J. L. Ortiz, X. Norel, I. Gorenne, J. Verley, T. S. Abram, N. J. Cuthbert, S. R. Tudhope, P. Norman, P. Gardiner, and C. Brink. 1992. A second cysteinyl leukotriene receptor in human lung. J. Pharmacol. Exp. Ther. 263:800-805.
14. Tudhope, S. R., N. J. Cuthbert, T. S. Abram, M. A. Jennings, R. J. Maxey, A. M. Thompson, P. Norman, and P. J. Gardiner. 1994. BAY u9773, a novel antagonist of cysteinyl-leukotrienes with activity against two receptor subtypes. Eur. J. Pharmacol. 264:317-323.
15. Kenakin, T. P., R. A. Bond, and T. I. Bonner. 1992. II. Definition of pharmacological receptors. Pharmacol. Rev. 44:351-362.
16. Feuerstein, G. 1985. Autonomic pharmacology of leukotrienes. J. Auton. Pharmacol. 5:149-168.
17. 4 receptor in guinea-pig trachea. J. Pharmacol. Exp. Ther. 231:616-622.
18. Gardiner, P. J., T. S. Abram, and N. J. Cuthbert. 1990. Evidence for two leukotriene receptor types in the guinea-pig isolated ileum. Eur. J. Pharmacol. 182:291-299.
19. 2 on the ferret spleen strip. Eur. J. Pharmacol. 238:19-26.
20. Snyder, D. W., and R. D. Krell. 1986. Pharmacology of peptide leukotrienes on ferret isolated airway smooth muscle. Prostaglandins 32:189-200.
21. Cuthbert, N. J., T. S. Abram, and P. J. Gardiner. 1991. Leukotriene receptors in sheep respiratory tissue. Ann. N.Y. Acad. Sci. 629:402-404.
22. 4 in the guinea-pig lung. Biochem. Biophys. Res. Commun. 116:1136-1143.
23. 4 binding to rat lung membranes. J. Biol. Chem. 258:9616-9619.
24. Norman, P., T. S. Abram, N. J. Cuthbert, S. R. Tudhope, and P. J. Gardiner. 1994. Characterisation of leukotriene receptors on the rat lung strip. Eur. J. Pharmacol. 271:73-78.
25. Gardiner, P. J., T. S. Abram, S. R. Tudhope, N. J. Cuthbert, P. Norman, and C. Brink. 1994. Leukotriene receptors and their selective antagonists. In S.-E. Dahlen, P. Hedqvist, B. Samuelsson, W. A. Taylor, and J. Fritsch, editors. Advances in Prostaglandin, Thromboxane, and Leukotriene Research. Raven Press, New York. 49-61.
26. Snyder, D. W., R. E. Giles, R. A. Keith, Y. K. Yee, and R. D. Krell. 1987. In vitro pharmacology of ICI 198,615: a novel, potent and selective peptide leukotriene antagonist. J. Pharmacol. Exp. Ther. 243:548-556.
27. 4 binding to guinea-pig lung membranes: the correlation of binding affinity with activity on the guinea-pig ileum. Eur. J. Pharmacol. 182:301-312.
28. Wikstrom Jonsson, E. 1998. Functional characterization of receptors for cysteinyl leukotrienes in smooth muscle. Acta Physiol. Scand. 162:1-55.
29. 2 formation in isolated sensitized guinea pig lungs. Biochem. Pharmacol. 30:2491-2493.
30. Buckner, C. K., J. S. Fedyna, J. L. Robertson, J. A. Will, D. M. England, R. D. Krell, and R. Saban. 1990. An examination of the influence of the epithelium on contractile responses to peptidoleukotrienes and blockade by ICI 204,219 in isolated guinea pig trachea and human intralobar airways. J. Pharmacol. Exp. Ther. 252:77-85.
31. Hay, D. W. P., R. M. Muccitelli, S. S. Tucker, L. M. Vickery-Clark, K. A. Wilson, J. G. Gleason, R. F. Hall, M. A. Wasserman, and T. J. Torphy. 1987. Pharmacologic profile of SK&F 104353: a novel, potent and selective peptidoleukotriene receptor antagonist in guinea pig and human airways. J. Pharmacol. Exp. Ther. 243:474-481.
32. Ortiz, J. L., I. Gorenne, J. Cortijo, A. Seller, C. Labat, B. Sarria, T. S. Abram, P. J. Gardiner, E. Morcillo, and C. Brink. 1995. Leukotriene receptor on human pulmonary vascular endothelium. Br. J. Pharmacol. 115:1382-1386.
33. Snyder, D. W., D. Aharony, P. Dobson, B. S. Tsai, and R. D. Krell. 1984. Pharmacological and biochemical evidence for metabolism of peptide leukotrienes by guinea-pig airway smooth muscle in vitro. J. Pharmacol. Exp. Ther. 231:224-229.
34. 4 receptors. J. Pharmacol. Exp. Ther. 248:581-588.
35. 4-binding protein in rat liver cytosol as glutathione S-transferase. J. Biol. Chem. 261:8540-8546.
36. 4 binding site in cellular membranes. J. Biol. Chem. 269:12816-12823.
37. 4. Proc. Natl. Acad. Sci. U.S.A. 89:11598-11602.
38. Keppler, D. 1992. Leukotrienes: biosynthesis, transport, inactivation, and analysis. Rev. Physiol. Biochem. Pharmacol. 121:1-30.
39. Ishikawa, T., M. Müller, C. Klünemann, T. Schaub, and D. Keppler. 1990. ATP-dependent primary active transport of cysteinyl leukotrienes across liver canalicular membrane. Role of the ATP-dependent transport system for glutathione S-conjugates. J. Biol. Chem. 265: 19279-19286.
40. 4 binding sites in guinea-pig uterus and lung preparations. J. Pharmacol. Exp. Ther. 232:80-87.
41. 4 in the longitudinal muscle of guinea-pig ileum. Eicosanoids 3:105-110.
42. 4 to membranes from guinea pig lung: regulation by ions and guanine nucleotides. Life Sci. 33:645-653.
43. 4 receptors: effects of cations and guanine nucleotides. Eur. J. Pharmacol. 106:241-253.
44. 4 receptors and signal transduction processes in rat basophilic leukemia cells. J. Biol. Chem. 262:4034-4041.
45. 4 receptor solubilized in an active form. Association and dissociation with an islet-activating protein-sensitive guanine nucleotide-binding protein. J. Biol. Chem. 265:21237-21241.
46. 4 receptors in guinea-pig lung membranes. Ann. N.Y. Acad. Sci. 524:162-180.
47. 4 antagonist, to guinea pig cardiac ventricular membranes. Prostaglandins 39:241-258.
48. 4 receptor in guinea pig lung membranes: interconversion of agonist-receptor binding affinity states. Mol. Pharmacol. 35:795-802.
49. 4 receptor in guinea pig lung. J. Biol. Chem. 268:6487-6495.
50. 4 receptors in adult and fetal human lung. Biochem. Pharmacol. 34:4311-4317.
51. 3H-ICI 198,615 in human lung parenchyma. Biochem. Pharmacol. 44:1411-1415.
52. De Lean, A., J. M. Stadel, and R. J. Lefkowitz. 1980. A ternary complex model explains the agonist-specific binding properties of the adenylate cyclase-coupled ß-adrenergic receptor. J. Biol. Chem. 255:7108-7117.
53. 4 in human fetal lung. Prostaglandins 27:961-974.
54. 4 in membranes from human lung. Biochem. Pharmacol. 34:2831-2837.
55. 4 in human bronchi. J. Pharmacol. Exp. Ther. 242:1019-1024.
56. 4 transport mediated by an ATP-dependent glutathione S-conjugate carrier in rat heart and liver plasma membranes. FEBS Lett. 259:95-98.
57. 4 functional activity with binding affinity. Eur. J. Pharmacol. 143:323-334.