Tetrahydroprotoberberines inhibit lipid peroxidation and scavenge hydroxyl free radicals

Acta Pharmacologica Sinica

Volumn 21, Issue 5, 2000, Pages 477-480

  Jin, Xi Lu ^b   Shao, Yue ^a   Wang, Ming Jie ^b   Chen, Li Juan ^a   Jin, Guo Zhang ^a  

^a INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

^b FUDAN UNIVERSITY   (China)

Author keywords

Free radicals; Lipid peroxidation; Malondialdehyde; Mitochondria; Stepholidine

Indexed keywords

ASCORBIC ACID; BERBINE DERIVATIVE; HYDROXYL RADICAL; IRON; MALONALDEHYDE; OXYGEN; OXYGEN RADICAL; PYROGALLOL; SCAVENGER; STEPHOLIDINE; TETRAHYDROPROTOBERBERINE 18; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; DRUG POTENCY; LIPID BRAIN LEVEL; LIPID LIVER LEVEL; LIPID PEROXIDATION; LIVER MITOCHONDRION; MALE; NONHUMAN; RAT;

ANIMALS; ANTIOXIDANTS; BERBERINE; BERBERINE ALKALOIDS; BRAIN; FREE RADICAL SCAVENGERS; HYDROXYL RADICAL; LIPID PEROXIDATION; LIVER; MALE; MALONDIALDEHYDE; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0034107414     PISSN: 02539756     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. 1 dopamine receptors in calf striatum. Biochem Pharmacol 1997; 54: 227-32.
2. 2 receptors in calf striatum. Acta Pharmacol Sin 1997; 18: 225-30.
3. 1 agonistic action of l-stepholidine in the 6-OHDA-lesioned rat striatum. Acta Physiol Sin 1999; 51: 65-72.
4. 1 agonistic action of stepholidine in lesioned rats. Biochem Pharmacol 1997; 54: 233-40.
5. Cai N, Jin GZ, Zhang ZD. A controlled study on treatment of tartive dyskinesia by l-stepholidine. Chin J Neurol Psychiatry 1988; 21: 281-3.
6. Li RK, Chen LJ, Zhao H, Jin GZ. Treatment of Parkinson disease with l-stepholidine (SPD) plus bromocriptine. Chin J Integrated Tradit West Med 1999; 19: 428-9.
7. Ogawa N, Edamatsu R, Mizukawa K, Asanuma M, Kohno M, Mori A. Degeneration of dopaminergic neurons and free radicals: possible participation of levodopa. Adv Neurol 1993; 60: 242-50.
8. Adams JD Jr, Odunze IN. Oxygen free radicals and Parkinson's disease. Free Radic Biol Med 1991; 10: 161-9.
9. Fahn S, Cohen G. The oxidant stress hypothesis in Parkiason's disease: evidence supporting it. Ann Neurol 1992; 32: 801-12.
10. 1 receptor agonist, A-86929: an acute study in parkinsonian levedopa-primed monkeys. Neurology 1997; 49: 421-6.
11. Ogawa N, Tanaka K, Asanuma M, Kawai M, Masumizu T, Kohno M, et al. Bromocriptine protects mice against 6-hydroxydopamine and scavenges hydroxyl free radicals in vitro. Brain Res 1994; 657: 207-13.
12. Xu CF, Sun LY. The effect of extract form Equisetum Hyemale on forming of mouse' brain heart and lung lipid peroxide. Chin J Mod Appl Pharm 1998; 15: 5-7.
13. Lu XY. Injury in rat liver mitochondria induced by acsorbic acid and ferrous sulfate. Prog Biochem Biophys 1989; 16: 372-4, 382.
14. Wang J, Wu JF, Zhang JT. Studies on the anti-cerebral ischemia effect of total salvianolic acid. Chin Pharmacol Bull 1999; 15: 164-6.
15. Xie WH, Yao JF, Yuan QS. Modification of pyrogallol autoxidation method for assay of superoxide dismutase. Pharm Ind 1988; 19: 217-20.
16. Chen LJ, Xi Y, Pang DW, Zhou QT, Jin GZ. Effect of (±) 12-chloroscoulerine on brain dopamine receptors. Acta Pharmacol Sin 1996; 17: 185-9.