The anti-inflammatory peptides, antiflammins, regulate the expression of adhesion molecules on human leukocytes and prevent neutrophil adhesion to endothelial cells

FASEB Journal

Volumn 14, Issue 3, 2000, Pages 572-580

  Zouki, Christine ^a   Ouellet, Sophie ^a   Filep, János G ^a  

^a MAISONNEUVE ROSEMONT HOSPITAL   (Canada)

Author keywords

Inflammation; Integrin; L selectin; Lipocortin 1 derived peptides; Neutrophil recruitment

Indexed keywords

ANTIFLAMMIN; ANTIFLAMMIN 1; ANTIFLAMMIN 2; CD11 ANTIGEN; CD18 ANTIGEN; CELL ADHESION MOLECULE; DEXAMETHASONE; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; INTERCELLULAR ADHESION MOLECULE 1; L SELECTIN; LIPOCORTIN 1; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG; UTEROGLOBIN;

ANTIGEN EXPRESSION; ARTICLE; CELL INTERACTION; CONTROLLED STUDY; ENDOTHELIUM CELL; HOST RESISTANCE; HUMAN; HUMAN CELL; INFLAMMATION; LEUKOCYTE ADHERENCE; NEUTROPHIL; PRIORITY JOURNAL; PROTEIN EXPRESSION;

EID: 0034106834     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fasebj.14.3.572     Document Type: Article

References (44)

1. Cronstein, B. N., Kimmel, S. C., Levin, R. I., Martiniuk, F., and Weissmann, G. (1992) A mechanism for the antiinflammatory effects of corticosteroids: the glucocorticoid receptor regulates leukocyte adhesion to endothelial cells and expression of endothelial-leukocyte adhesion molecule 1 and intercellular adhesion molecule 1. Proc. Natl. Acad. Sci. USA 89, 9991-9995
2. Filep, J. G., Delalandre, A., Payette, Y., and Földes-Filep, E. (1997) Glucocorticoid receptor regulates expression of L-selectin and CD11/CD18 on human neutrophils. Circulation 96, 295-301
3. Goulding, N.J., Godolphin, J. L., Sharland, P. R., Peers, S. H., Sampson, M, Maddison, P. J., and Flower, R. J. (1990) Antiinflammatory lipocortin 1 production by peripheral blood leucocytes in response to hydrocortisone. Lancet 335, 1416-1418
4. Flower, R. J., and Rothwell, N. J. (1994) Lipocortin-1: cellular mechanisms and clinical relevance. Trends Pharmacol. Sci. 15, 71-76
5. Perretti, M., Ahluwalia, A., Harris, J. G., Goulding, N. J., and Flower, R. J. (1993) Lipocortin-1 fragments inhibit neutrophil accumulation and neutrophil-dependent edema in the mouse. J. Immunol. 151, 4306-4314
6. Miele, L., Cordella-Miele, E., Facchiano, A., and Mukherjee, A. B. (1988) Novel anti-inflammatory peptides from the region of highest similarity between uteroglobin and lipocortin I. Nature (London) 335, 726-730
7. 2 activity. Life Sci. 38, 1813-1819
8. 2 inhibitor with potential anti-inflammatory activity. Nature (London) 320, 77-81
9. 2 inhibitory activity. FEBS Lett. 247, 293-297
10. Marki, F., Pfeilschifter, J., Rink, H., and Wiesenberg, I. (1990) 'Antiflammins': two nonapeptide fragments of uteroglobin and lipocortin I have no phospholipase A2 inhibitory and antiinflammatory activity. FEBS Lett. 264, 171-175
11. 2 activity by uteroglobin and antiflammin peptides: Possible mechanism of action. Life Sci. 48, 453-464
12. Camussi, G., Tetta, C., Bussolino, F., and Baglioni, C. (1990) Antiinflammatory peptides (antiflammins) inhibit synthesis of platelet-activating factor, neutrophil aggregation and chemotaxis, and intradermal inflammatory reactions. J. Exp. Med. 171, 913-927
13. Moreno, J. J. (1996) Antiflammin-1, a nonapeptide of lipocortin-1, inhibits leukocyte chemotaxis but not arachidonic acid mobilization. Eur. J. Pharmacol. 314, 129-135
14. Vostal, J. G., Mukherjee, A. B., Miele, L., and Shulman, N. R. (1989) Novel peptides derived from a region of local homology between uteroglobin and lipocortin-1 inhibit platelet aggregation and secretion. Biochem. Biophys. Res. Commun. 165, 27-36
15. 2. Biochem. Pharmacol. 44, 519-525
16. Chan, C. C., Ni, M., Miele, L., Cordella-Miele, E., Ferrick, M., Mukherjee, A. B., and Nusseblatt, R. B. (1991) Effects of antiflammins on endotoxin-induced uveitis in rats. Arch. Ophthalmol. 109, 278-281
17. Butcher, E. C. (1991) Leukocyte endothelial cell migration: three (or more) steps to specificity and diversity. Cell 67, 1033-1036
18. Springer, T. A. (1994) Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell 76, 301-314
19. Lawrence, M. B., and Springer, T. A. (1991) Leukocytes roll on a selectin at physiologic flow rates: distinction from prerequisite for adhesion through integrins. Cell 65, 859-873
20. Tedder, T. F., Steeber, D. A., and Pizcueta, P. (1995) L-selectin-deficient mice have impaired leukocyte recruitment into inflammatory sites. J. Exp. Med. 181, 2259-2264
21. Kishimoto, T. K., Jutila, M. A., Berg, E. L., and Butcher, E. C. (1989) Neutrophil Mac-1 and MEL-14 adhesion proteins inversely regulated by chemotactic factors. Science 245, 1238-1241
22. Zimmerman, G. A., McIntyre, T. M., Mehra, M., and Prescott, S. M. (1990) Endothelial cell-associated platelet-activating factor: a novel mechanism for signaling intercellular adhesion. J. Cell Biol. 110, 529-540
23. Rainger, G. E., Fisher, A. C., and Nash, G. B. (1997) Endothelial-borne platelet-activating factor and interleukin-8 rapidly immobilize rolling neutrophils. Am. J. Physiol. 41, H114-H122
24. Kishimoto, T. K., Jutila, M. A., and Butcher, E. C. (1990) Identification of a human peripheral lymph node homing receptor: a rapidly down-regulated adhesion molecule. Proc. Natl. Acad. Sci. USA 87, 805-811
25. Leeuwenberg, J. F. M., von Asmuth, E. J. U., Jeunhomme, T. M. A. A., and Buurman, W. A. (1990) IFN-γ regulates the expression of the adhesion molecule ELAM-1 and IL-6 production by human endothelial cells in vitro. J. Immunol. 145, 2110-2114
26. Zouki, C., Beauchamp, M., Baron, C., and Filep, J. G. (1997) Prevention of in vitro neutrophil adhesion to endothelial cells through shedding of L-selectin by C-reactive protein and peptides derived from C-reactive protein. J. Clin. Invest. 100, 522-529
27. Perretti, M., Croxtall, J. D., Wheller, S. K., Goulding, N. J., Hannon, R., and Flower, R. J. (1996) Mobilizing lipocortin 1 in adherent human leukocytes downregulates their transmigration. Nature Med. 22, 1259-1262
28. Mancuso, F., Flower, R. J., and Perretu, M. (1995) Leukocyte transmigration, but not rolling or adhesion, is selectively inhibited by dexamethasone in the hamster post-capillary venule: involvement of endogenous lipocorun 1. J. Immunol. 155, 377-386
29. Cuzzocrea, S., Tailor, A., Zingarelli, B., Salzman, A. L., Flower, R. J., Szabó, C., and Perretti, M. (1997) Lipocortin 1 protects against splanchnic artery occlusion and reperfusion injury by affecting neutrophil migration. J. Immunol. 159, 5089-5097
30. Goulding, N. J., and Guyre, P. M. (1993) Lipocortin 1 binding to human leukocytes correlates with its ability to inhibit IgG interactions with Fc gamma receptors. Biochem. Biophys. Res. Commun. 192, 351-358
31. Pepinsky, R. B., Tizard, R., Mattaliano, R. J., Sinclair, L. K., Miller, G. T., Browning, J. L., Chow P., Burne, C., Huang, K. S., Pratt, D., Wachter, L., Hession, C., Frey, A. Z., and Wallner, B. P. (1988) Five distinct calcium and phospholipid binding proteins share homology with lipocortin I. J. Biol. Chem. 263, 10799-108111
32. Migaki, G. I., Kahn, J., and Kishimoto, T. K. (1995) Mutational analysis of the membrane-proximal cleavage site of L-selectin: relaxed sequence specificity surrounding the cleavage site. J. Exp. Med. 182, 549-557
33. Chen, A., Engel, P., and Tedder, T. F. (1995) Structural requirements regulate endoproteolytic release of the L-selectin (CD62L) adhesion receptor from the cell surface of leukocytes. J. Exp. Med. 182, 519-530
34. Haribabu, B., Steeber, D. A., Ali, H., Richardson, R. M., Snyderman, R., and Tedder, T. F. (1997) Chemoattractant receptor-induced phosphorylation of L-selectin. J. Biol. Chem. 272, 13961-13965
35. Kahn, J., Walcheck, B., Migaki, G. I., Jutila, M. A., and Kishimoto, T. K. (1998) Calmodulin regulates L-selectin adhesion molecule expression and function through a protease-dependent mechanism. Cell 92, 809-818
36. Loftus, J. C., and Liddington, R. C. (1997) New insights into integrin-ligand interaction. J Clin. Invest. 100 (Suppl.), S77-S81
37. McDowall, A., Leitinger, B., Stanley, P., Bates, P. A, Randi, A. M., and Hogg, N. (1998) The I domain of integrin leukocyte function-associated antigen-1 is involved in a conformational change leading to high affinity binding to ligand intercellular adhesion molecule-1 (ICAM-1). J. Biol. Chem. 273, 27396-27403
38. Lee, J. O., Bankston, L.A., Arnaout, M. A., and Liddington, R. C. (1995) Two conformations of the integrin A-domain (I-domain): a pathway for activation? Structure (London) 3, 1333-1340
39. Groyer, A., Schweizer-Groyer, G., Cadepond, F., Mavuller, M., and Beaulieu, E. E. (1987) Antiglucocorticosteroid effects suggest why steroid hormone is required for receptors to bind DNA in vivo but not in vitro. Nature (London) 328, 624-626
40. Montgomery, K. F., Osborn, L., Hession, C., Tizard, R., Goff, D., Vassallo, C., Tarr, P. I., Bomsztyk, K., Cobb, R., Harlan, J. M., and Pohlman, T. H. (1991) Activation of endothelial-leukocyte adhesion molecule 1 (ELAM-1) gene transcription. Proc. Natl. Acad. Sci. USA 88, 6523-6527
41. Entman, M. L., Michael, L., Rossen, R. D., Dreyer, W. J., Anderson, D. C., Taylor, A. A., and Smith, C. W. (1991) Inflammation in the course of early myocardial ischemia. FASEB J. 5, 2529-2537
42. Ma, X. L., Tsao, P., and Lefer, A. M. (1991) Antibody to CD-18 exerts endothelial and cardiac protective effects in myocardial ischemia and reperfusion. J. Clin. Invest. 88, 1237-1243
43. Johnson, B. A., Haines, G. K., Harlow, L. A., and Koch, A. E. (1993) Adhesion molecule expression in human synovial tissue. Arth. Rheum. 36, 137-146
44. Diaz-González, F., González-Alvaro, I., Campanero, M. R., Mollinedo, F., del Pozo, M. A., Muñoz, C., Pivel, J. P., and Sanchez-Madrid, F. (1995) Prevention of in vivo neutrophil-endothelial attachment through shedding of L-selectin by non-steroidal antiinflammatory drugs. J. Clin. Invest. 95, 1756-1765