메뉴 건너뛰기




Volumn 49, Issue 1, 2000, Pages 4-16

Pharmacogenomics of cytochrome P450 and other enzymes involved in biotransformation of xenobiotics

Author keywords

Bioavailability; Cytochrome P450; Environmental genome project; Mutagenicity assays; Polymorphisms

Indexed keywords

CYTOCHROME P450; XENOBIOTIC AGENT;

EID: 0034106141     PISSN: 02724391     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2299(200001)49:1<4::AID-DDR2>3.0.CO;2-R     Document Type: Article
Times cited : (34)

References (133)
  • 2
    • 0028168178 scopus 로고
    • Genetic susceptibility to lung cancer with special emphasis on CYP1A1 and GSTM1: A study on host factors in relation to age at onset, gender and histological cancer types
    • Alexandrie AK, Sundberg MI, Seidegård J, Tornling G, Rannug A. 1994. Genetic susceptibility to lung cancer with special emphasis on CYP1A1 and GSTM1: a study on host factors in relation to age at onset, gender and histological cancer types. Carcinogenesis 15:1785-1790.
    • (1994) Carcinogenesis , vol.15 , pp. 1785-1790
    • Alexandrie, A.K.1    Sundberg, M.I.2    Seidegård, J.3    Tornling, G.4    Rannug, A.5
  • 3
    • 0000313919 scopus 로고    scopus 로고
    • Glutathione transferases
    • Guengerich FP, editor. Oxford: Elsevier Science
    • Armstrong RN. 1997. Glutathione transferases. In: Guengerich FP, editor. Biotransformation, vol. 3. Comprehensive toxicology. Oxford: Elsevier Science. p 307-327.
    • (1997) Biotransformation, Vol. 3. Comprehensive Toxicology , vol.3 , pp. 307-327
    • Armstrong, R.N.1
  • 4
    • 0032967962 scopus 로고    scopus 로고
    • Development of a new genotoxicity test system with Salmonella typhimurium OY1001/1A2 expressing human cytochrome P450 1A2 and NADPH-cytochrome P450 reductase
    • Aryal P, Yoshikawa K, Terashita T, Guengerich FP, Shimada T, Oda Y. 1999. Development of a new genotoxicity test system with Salmonella typhimurium OY1001/1A2 expressing human cytochrome P450 1A2 and NADPH-cytochrome P450 reductase. Mutat Res 442:113-120.
    • (1999) Mutat Res , vol.442 , pp. 113-120
    • Aryal, P.1    Yoshikawa, K.2    Terashita, T.3    Guengerich, F.P.4    Shimada, T.5    Oda, Y.6
  • 5
    • 0021130765 scopus 로고
    • Metabolic oxidation phenotypes as markers for susceptibility to lung cancer
    • Ayesh R, Idle JR, Ritchie JC, Crothers MJ, Hetzel MR. 1984. Metabolic oxidation phenotypes as markers for susceptibility to lung cancer. Nature 312:169-170.
    • (1984) Nature , vol.312 , pp. 169-170
    • Ayesh, R.1    Idle, J.R.2    Ritchie, J.C.3    Crothers, M.J.4    Hetzel, M.R.5
  • 7
    • 0002231220 scopus 로고
    • Food-drug interactions: Emphasis on grapefruit juice effects
    • Bailey DG. 1995. Food-drug interactions: emphasis on grapefruit juice effects. Can J Clin Pharmacol 2:10-14.
    • (1995) Can J Clin Pharmacol , vol.2 , pp. 10-14
    • Bailey, D.G.1
  • 8
    • 0029757088 scopus 로고    scopus 로고
    • Maximizing expression of eukaryotic cytochrome P450s in Escherichia coli
    • Barnes HJ. 1996. Maximizing expression of eukaryotic cytochrome P450s in Escherichia coli. Methods Enzymol 272:3-14.
    • (1996) Methods Enzymol , vol.272 , pp. 3-14
    • Barnes, H.J.1
  • 9
    • 0342723936 scopus 로고
    • Über gepaarte schwefelsäuren in harn
    • Baumann E. 1876a. Über gepaarte Schwefelsäuren in Harn. Pflügers Arch Physiol 12:69-70.
    • (1876) Pflügers Arch Physiol , vol.12 , pp. 69-70
    • Baumann, E.1
  • 10
    • 84979120258 scopus 로고
    • Über sulfosäuren im harn
    • Baumann E. 1876b. Über Sulfosäuren im Harn. Chem Ber 9:54-58.
    • (1876) Chem Ber , vol.9 , pp. 54-58
    • Baumann, E.1
  • 11
    • 0030701529 scopus 로고    scopus 로고
    • Oxidation kinetics of ethanol by human cytochrome P450 2E1. Rate-limiting product release accounts for effects of isotopic hydrogen substitution and cytochrome b5 on steady-state kinetics
    • Bell LC, Guengerich FP. 1997. Oxidation kinetics of ethanol by human cytochrome P450 2E1. Rate-limiting product release accounts for effects of isotopic hydrogen substitution and cytochrome b5 on steady-state kinetics. J Biol Chem 272:29643-29651.
    • (1997) J Biol Chem , vol.272 , pp. 29643-29651
    • Bell, L.C.1    Guengerich, F.P.2
  • 12
    • 0033588164 scopus 로고    scopus 로고
    • Kinetics of cytochrome P450 2E1-catalyzed oxidation of ethanol to acetic acid via acetaldehyde
    • Bell-Parikh LC, Guengerich FP. 1999. Kinetics of cytochrome P450 2E1-catalyzed oxidation of ethanol to acetic acid via acetaldehyde. J Biol Chem 274:23833-23840.
    • (1999) J Biol Chem , vol.274 , pp. 23833-23840
    • Bell-Parikh, L.C.1    Guengerich, F.P.2
  • 13
    • 0027473240 scopus 로고
    • Cross-coupling of signal transduction pathways: The dioxin receptor mediate induction of cytochrome P-450IA1 expression via a protein kinase C-dependent mechanism
    • Berghard A, Gradin K, Pongratz I, Whitelaw M, Poellinger L. 1993. Cross-coupling of signal transduction pathways: the dioxin receptor mediate induction of cytochrome P-450IA1 expression via a protein kinase C-dependent mechanism. Mol Cell Biol 13:677-689.
    • (1993) Mol Cell Biol , vol.13 , pp. 677-689
    • Berghard, A.1    Gradin, K.2    Pongratz, I.3    Whitelaw, M.4    Poellinger, L.5
  • 14
    • 0023224579 scopus 로고
    • Inhibition by pentachlorophenol of the initiating and promoting activities of 1′-hydroxysafrole for the formation of enzyme-altered foci and tumors in rat liver
    • Boberg EW, Liem A, Miller EC, Miller JA. 1987. Inhibition by pentachlorophenol of the initiating and promoting activities of 1′-hydroxysafrole for the formation of enzyme-altered foci and tumors in rat liver. Carcinogenesis 8:531-539.
    • (1987) Carcinogenesis , vol.8 , pp. 531-539
    • Boberg, E.W.1    Liem, A.2    Miller, E.C.3    Miller, J.A.4
  • 15
    • 0016832118 scopus 로고
    • Effect of rifampicin treatment on the metabolism of oestradiol and 17α-ethinyloestradiol by human liver microsomes
    • Bolt HM, Kappus H, Bolt M. 1975. Effect of rifampicin treatment on the metabolism of oestradiol and 17α-ethinyloestradiol by human liver microsomes. Eur J Clin Pharmacol 8:301-307.
    • (1975) Eur J Clin Pharmacol , vol.8 , pp. 301-307
    • Bolt, H.M.1    Kappus, H.2    Bolt, M.3
  • 16
    • 0018575322 scopus 로고
    • Heterogeneity and new molecular forms of human liver alcohol dehydrogenase
    • Bosron WF, Li TK, Vallee BL. 1979. Heterogeneity and new molecular forms of human liver alcohol dehydrogenase. Biochem Biophys Res Commun 91:1549-1555.
    • (1979) Biochem Biophys Res Commun , vol.91 , pp. 1549-1555
    • Bosron, W.F.1    Li, T.K.2    Vallee, B.L.3
  • 17
    • 0027450886 scopus 로고
    • Genotype and phenotype of glutathione S-transferase class μ isoenzymes μ and ψ in lung cancer patients and controls
    • Brockmöller J, Kerb R, Drakoulis N, Nitz M, Roots I. 1993. Genotype and phenotype of glutathione S-transferase class μ isoenzymes μ and ψ in lung cancer patients and controls. Cancer Res 53:1004-1011.
    • (1993) Cancer Res , vol.53 , pp. 1004-1011
    • Brockmöller, J.1    Kerb, R.2    Drakoulis, N.3    Nitz, M.4    Roots, I.5
  • 19
    • 0024343858 scopus 로고
    • Human cytochrome P-450PA (P-450IA2), the phenacetin O-deethylase, is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylamines
    • Butler MA, Iwasaki M, Guengerich FP, Kadlubar FF. 1989. Human cytochrome P-450PA (P-450IA2), the phenacetin O-deethylase, is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylamines. Proc Natl Acad Sci USA 86:7696-7700.
    • (1989) Proc Natl Acad Sci USA , vol.86 , pp. 7696-7700
    • Butler, M.A.1    Iwasaki, M.2    Guengerich, F.P.3    Kadlubar, F.F.4
  • 21
    • 0031914323 scopus 로고    scopus 로고
    • The antibiotic rifampicin is a nonsteroidal ligand and activator of the human glucocorticoid receptor
    • Calleja C, Pascussi JM, Mani JC, Maurel P, Vilarem MJ. 1998. The antibiotic rifampicin is a nonsteroidal ligand and activator of the human glucocorticoid receptor. Nat Med 4:92-96.
    • (1998) Nat Med , vol.4 , pp. 92-96
    • Calleja, C.1    Pascussi, J.M.2    Mani, J.C.3    Maurel, P.4    Vilarem, M.J.5
  • 22
    • 0000823974 scopus 로고    scopus 로고
    • Genetic susceptibility and the common cancers
    • Caporaso N. 1996. Genetic susceptibility and the common cancers. BioMarkers 1:174-177.
    • (1996) BioMarkers , vol.1 , pp. 174-177
    • Caporaso, N.1
  • 24
    • 0003085358 scopus 로고    scopus 로고
    • Monoamine oxidase and flavin-containing monooxygenases
    • Guengerich FP, editor. Oxford: Elsevier Science
    • Cashman JR. 1997. Monoamine oxidase and flavin-containing monooxygenases. In: Guengerich FP, editor. Biotransformation, vol. 3. Comprehensive toxicology. Oxford: Elsevier Science. p 69-96.
    • (1997) Biotransformation, Vol. 3. Comprehensive Toxicology , vol.3 , pp. 69-96
    • Cashman, J.R.1
  • 25
    • 0006608214 scopus 로고
    • Does DNA damage play a role in rodent liver cancer induced by peroxisome proliferators?
    • Cattley RC, Preston RJ. 1995. Does DNA damage play a role in rodent liver cancer induced by peroxisome proliferators? Chem Ind Inst Toxicol Activities 15:1-7.
    • (1995) Chem Ind Inst Toxicol Activities , vol.15 , pp. 1-7
    • Cattley, R.C.1    Preston, R.J.2
  • 26
    • 0003929270 scopus 로고    scopus 로고
    • Metallothionein and intracellular sequestration of metals
    • Guengerich FP, editor. Oxford: Elsevier Science
    • Cherian MG. 1997. Metallothionein and intracellular sequestration of metals. In: Guengerich FP, editor. Biotransformation, vol. 3. Comprehensive toxicology. Oxford: Elsevier Science, p 489-503.
    • (1997) Biotransformation, Vol. 3. Comprehensive Toxicology , vol.3 , pp. 489-503
    • Cherian, M.G.1
  • 27
    • 84930288145 scopus 로고
    • The metabolism of methylated aminoazo dyes. V. Evidence for induction of enzyme synthesis in the rat by 3-methylcholanthrene
    • Conney AH, Miller EC, Miller JA. 1956. The metabolism of methylated aminoazo dyes. V. Evidence for induction of enzyme synthesis in the rat by 3-methylcholanthrene. Cancer Res 16:450-459.
    • (1956) Cancer Res , vol.16 , pp. 450-459
    • Conney, A.H.1    Miller, E.C.2    Miller, J.A.3
  • 28
    • 0032968261 scopus 로고    scopus 로고
    • Evaluation of Escherichia coli DJ4309 expressing human P450 1A2 in mutagenicity testing of complex food mixtures
    • Constable A, Varga N, Josephy PD, Guy P, Turesky RJ. 1999. Evaluation of Escherichia coli DJ4309 expressing human P450 1A2 in mutagenicity testing of complex food mixtures. Mutat Res 442:79-87.
    • (1999) Mutat Res , vol.442 , pp. 79-87
    • Constable, A.1    Varga, N.2    Josephy, P.D.3    Guy, P.4    Turesky, R.J.5
  • 32
    • 0001360416 scopus 로고    scopus 로고
    • Genetic metabolic polymorphisms and the risk of cancer: A review of the literature
    • d'Errico A, Taioli E, Chen X, Vineis P. 1996. Genetic metabolic polymorphisms and the risk of cancer: a review of the literature. BioMarkers 1:149-173.
    • (1996) BioMarkers , vol.1 , pp. 149-173
    • D'Errico, A.1    Taioli, E.2    Chen, X.3    Vineis, P.4
  • 33
    • 0030667523 scopus 로고    scopus 로고
    • Missense mutation in flavin-containing mono-oxygenase 3 gene. FMO3, underlies fish-odour syndrome
    • Dolphin CT, Janmohamed A, Smith RL, Shephard EA, Phillips IR. 1997. Missense mutation in flavin-containing mono-oxygenase 3 gene. FMO3, underlies fish-odour syndrome. Nat Gen 17:491-494.
    • (1997) Nat Gen , vol.17 , pp. 491-494
    • Dolphin, C.T.1    Janmohamed, A.2    Smith, R.L.3    Shephard, E.A.4    Phillips, I.R.5
  • 35
    • 0028043708 scopus 로고
    • Structure-function studies of human arylamine N-acetyltransferases NAT1 and NAT2
    • Dupret J-M, Goodfellow GH, Janezic SA, Grant DM. 1994. Structure-function studies of human arylamine N-acetyltransferases NAT1 and NAT2. J Biol Chem 269:26830-26835.
    • (1994) J Biol Chem , vol.269 , pp. 26830-26835
    • Dupret, J.-M.1    Goodfellow, G.H.2    Janezic, S.A.3    Grant, D.M.4
  • 37
    • 0032808416 scopus 로고    scopus 로고
    • Concise review: Gene expression applied to toxicology
    • Farr S, Dunn RT II. 1999. Concise review: gene expression applied to toxicology. Toxicol Sci 50:1-9.
    • (1999) Toxicol Sci , vol.50 , pp. 1-9
    • Farr, S.1    Dunn R.T. II2
  • 38
    • 0030588661 scopus 로고    scopus 로고
    • Recombinant DNA technology as an investigative tool in drug metabolism research
    • Friedberg T, Wolf CR. 1996. Recombinant DNA technology as an investigative tool in drug metabolism research. Adv Drug Deliv Rev 22:187-213.
    • (1996) Adv Drug Deliv Rev , vol.22 , pp. 187-213
    • Friedberg, T.1    Wolf, C.R.2
  • 39
    • 0029662019 scopus 로고    scopus 로고
    • The cyclooxygenase-2 structure: New drugs for an old target?
    • Garavito RM. 1996. The cyclooxygenase-2 structure: new drugs for an old target? Nat Struct Biol 3:897-901.
    • (1996) Nat Struct Biol , vol.3 , pp. 897-901
    • Garavito, R.M.1
  • 40
    • 0025067462 scopus 로고
    • Molecular genetics of the P-450 superfamily
    • Gonzalez FJ. 1990. Molecular genetics of the P-450 superfamily. Pharmacol Ther 45:1-38.
    • (1990) Pharmacol Ther , vol.45 , pp. 1-38
    • Gonzalez, F.J.1
  • 41
    • 0027983085 scopus 로고
    • Pharmacogenetic phenotyping and genotyping: Present status and future potential
    • Gonzalez FJ, Idle JR. 1994. Pharmacogenetic phenotyping and genotyping: present status and future potential. Clin Pharmacokinet 26:59-70.
    • (1994) Clin Pharmacokinet , vol.26 , pp. 59-70
    • Gonzalez, F.J.1    Idle, J.R.2
  • 42
    • 0025940815 scopus 로고
    • Molecular genetics of the debrisoquinsparteine polymorphism
    • Gonzalez FJ, Meyer UA. 1991. Molecular genetics of the debrisoquinsparteine polymorphism. Clin Pharmacol Ther 50:233-238.
    • (1991) Clin Pharmacol Ther , vol.50 , pp. 233-238
    • Gonzalez, F.J.1    Meyer, U.A.2
  • 43
    • 0026695811 scopus 로고
    • Salmonella typhimurium strains expressing human arylamine N-acetyltransferases: Metabolism and mutagenic activation of aromatic amines
    • Grant DM, Josephy PD, Lord HL, Morrison LD. 1992. Salmonella typhimurium strains expressing human arylamine N-acetyltransferases: metabolism and mutagenic activation of aromatic amines. Cancer Res 52:3961-3964.
    • (1992) Cancer Res , vol.52 , pp. 3961-3964
    • Grant, D.M.1    Josephy, P.D.2    Lord, H.L.3    Morrison, L.D.4
  • 44
    • 0001786847 scopus 로고
    • Enzymology of rat liver cytochromes P-450
    • Guengerich FP, editor. Boca Raton, FL: CRC Press
    • Guengerich FP. 1987. Enzymology of rat liver cytochromes P-450. In: Guengerich FP, editor. Mammalian cytochromes P-450, vol. 1. Boca Raton, FL: CRC Press. p 1-54.
    • (1987) Mammalian Cytochromes P-450 , vol.1 , pp. 1-54
    • Guengerich, F.P.1
  • 45
    • 0023951396 scopus 로고
    • Roles of cytochrome P-450 enzymes in chemical carcinogenesis and cancer chemotherapy
    • Guengerich FP. 1988a. Roles of cytochrome P-450 enzymes in chemical carcinogenesis and cancer chemotherapy. Cancer Res 48:2946-2954.
    • (1988) Cancer Res , vol.48 , pp. 2946-2954
    • Guengerich, F.P.1
  • 46
    • 0023883363 scopus 로고
    • Oxidation of 17α-ethynylestradiol by human liver cytochrome P-450
    • Guengerich FP. 1988b. Oxidation of 17α-ethynylestradiol by human liver cytochrome P-450. Mol Pharmacol 33:500-508.
    • (1988) Mol Pharmacol , vol.33 , pp. 500-508
    • Guengerich, F.P.1
  • 47
    • 0024593072 scopus 로고
    • Characterization of human microsomal cytochrome P-450 enzymes
    • Guengerich FP. 1989. Characterization of human microsomal cytochrome P-450 enzymes. Annu Rev Pharmacol Toxicol 29:241-264.
    • (1989) Annu Rev Pharmacol Toxicol , vol.29 , pp. 241-264
    • Guengerich, F.P.1
  • 48
    • 0002888510 scopus 로고
    • Human cytochrome P450 enzymes
    • Ortiz de Montellano PR, editor. New York: Plenum Press
    • Guengerich FP. 1995. Human cytochrome P450 enzymes. In: Ortiz de Montellano PR, editor. Cytochrome P450, 2nd ed. New York: Plenum Press. p 473-535.
    • (1995) Cytochrome P450, 2nd Ed. , pp. 473-535
    • Guengerich, F.P.1
  • 49
    • 0004946256 scopus 로고    scopus 로고
    • Introduction and historical perspective
    • Guengerich FP, editor. Oxford: Elsevier Science
    • Guengerich FP. 1997a. Introduction and historical perspective. In: Guengerich FP, editor. Biotransformation, vol. 3, Comprehensive toxicology. Oxford: Elsevier Science, p 1-6.
    • (1997) Biotransformation, Vol. 3, Comprehensive Toxicology , vol.3 , pp. 1-6
    • Guengerich, F.P.1
  • 50
  • 52
    • 0031726283 scopus 로고    scopus 로고
    • The environmental genome project: Functional analysis of polymorphisms
    • Guengerich FP. 1998. The environmental genome project: functional analysis of polymorphisms. Environ Health Perspect 106:365-368.
    • (1998) Environ Health Perspect , vol.106 , pp. 365-368
    • Guengerich, F.P.1
  • 53
    • 0034097234 scopus 로고    scopus 로고
    • Metabolism of chemical carcinogens
    • in press
    • Guengerich FP. 2000. Metabolism of chemical carcinogens. Carcinogenesis 21:(in press).
    • (2000) Carcinogenesis , vol.21
    • Guengerich, F.P.1
  • 54
    • 0025992864 scopus 로고
    • Oxidation of toxic and carcinogenic chemicals by human cytochrome P-450 enzymes
    • Guengerich FP, Shimada T. 1991. Oxidation of toxic and carcinogenic chemicals by human cytochrome P-450 enzymes. Chem Res Toxicol 4:391-407.
    • (1991) Chem Res Toxicol , vol.4 , pp. 391-407
    • Guengerich, F.P.1    Shimada, T.2
  • 55
    • 0029852566 scopus 로고    scopus 로고
    • New applications of bacterial systems to problems in toxicology
    • Guengerich FP, Gillam EMJ, Shimada T. 1996. New applications of bacterial systems to problems in toxicology. Crit Rev Toxicol 26:551-583.
    • (1996) Crit Rev Toxicol , vol.26 , pp. 551-583
    • Guengerich, F.P.1    Gillam, E.M.J.2    Shimada, T.3
  • 59
    • 0025753960 scopus 로고
    • Effects of individual mutations in the P-450 (C21) pseudogene on the P-450 (C21) activity and their distribution in the patient genomes of congenital steroid 21-hydroxylase deficiency
    • Higashi Y, Hiromasa T, Tanae A, Miki T, Nakura J, Kondo T, Ohura T, Ogawa E, Nakayama K, Fujii-Kuriyama Y. 1991. Effects of individual mutations in the P-450 (C21) pseudogene on the P-450 (C21) activity and their distribution in the patient genomes of congenital steroid 21-hydroxylase deficiency. J Biochem 109:638-644.
    • (1991) J Biochem , vol.109 , pp. 638-644
    • Higashi, Y.1    Hiromasa, T.2    Tanae, A.3    Miki, T.4    Nakura, J.5    Kondo, T.6    Ohura, T.7    Ogawa, E.8    Nakayama, K.9    Fujii-Kuriyama, Y.10
  • 60
    • 0026671408 scopus 로고
    • Changes in the pharmacokinetics and electrocardiographic pharmacodynamics of terfenadine with concomitant administration of erythromycin
    • Honig PK, Woosley RL, Zamani K, Conner DP, Cantilena LR Jr. 1992. Changes in the pharmacokinetics and electrocardiographic pharmacodynamics of terfenadine with concomitant administration of erythromycin. Clin Pharmacol Ther 52:231-238.
    • (1992) Clin Pharmacol Ther , vol.52 , pp. 231-238
    • Honig, P.K.1    Woosley, R.L.2    Zamani, K.3    Conner, D.P.4    Cantilena L.R., Jr.5
  • 61
    • 0343158399 scopus 로고    scopus 로고
    • The nuclear orphan receptor CAR-RXR heterodimer activates the phenobarbital-responsive enhancer module of the CYP2B gene
    • Honkakosski P, Zelko I, Sueyoshi T, Negishi M. 1998. The nuclear orphan receptor CAR-RXR heterodimer activates the phenobarbital-responsive enhancer module of the CYP2B gene. Mol Cell Biol 18:1-7.
    • (1998) Mol Cell Biol , vol.18 , pp. 1-7
    • Honkakosski, P.1    Zelko, I.2    Sueyoshi, T.3    Negishi, M.4
  • 62
    • 0019419633 scopus 로고
    • Is there a genetic predisposition to phenformin-induced lactic acidosis
    • Idle JR, Oates NS, Shah RR, Smith RL. 1981. Is there a genetic predisposition to phenformin-induced lactic acidosis. Br J Clin Pharmacol 11:418P-419P.
    • (1981) Br J Clin Pharmacol , vol.11
    • Idle, J.R.1    Oates, N.S.2    Shah, R.R.3    Smith, R.L.4
  • 63
    • 0016075464 scopus 로고
    • Anti-epileptic drugs and failure of oral contraceptives
    • Janz D, Schmidt D. 1974. Anti-epileptic drugs and failure of oral contraceptives. Lancet i:1113.
    • (1974) Lancet , vol.1 , pp. 1113
    • Janz, D.1    Schmidt, D.2
  • 64
    • 0030894660 scopus 로고    scopus 로고
    • Conjugation of highly reactive aflatoxin B1 8,9-exo-epoxide catalyzed by rat and human glutathione transferases: Estimation of kinetic parameters
    • Johnson WW, Ueng Y-F, Mannervik B, Widersten M, Hayes JD, Sherratt PJ, Ketterer B, Guengerich FP. 1997. Conjugation of highly reactive aflatoxin B1 8,9-exo-epoxide catalyzed by rat and human glutathione transferases: estimation of kinetic parameters. Biochemistry 36:3056-3060.
    • (1997) Biochemistry , vol.36 , pp. 3056-3060
    • Johnson, W.W.1    Ueng, Y.-F.2    Mannervik, B.3    Widersten, M.4    Hayes, J.D.5    Sherratt, P.J.6    Ketterer, B.7    Guengerich, F.P.8
  • 65
    • 0028834113 scopus 로고
    • Bioactivation of aromatic amines by recombinant human cytochrome P450 1A2 expressed in bacteria: A substitute for mammalian tissue preparations in mutagenicity testing
    • Josephy PD, DeBruin LS, Lord HL, Oak J, Evans DH, Guo Z, Dong M-S, Guengerich FP. 1995. Bioactivation of aromatic amines by recombinant human cytochrome P450 1A2 expressed in bacteria: a substitute for mammalian tissue preparations in mutagenicity testing. Cancer Res 55:799-802.
    • (1995) Cancer Res , vol.55 , pp. 799-802
    • Josephy, P.D.1    DeBruin, L.S.2    Lord, H.L.3    Oak, J.4    Evans, D.H.5    Guo, Z.6    Dong, M.-S.7    Guengerich, F.P.8
  • 66
    • 2642703427 scopus 로고    scopus 로고
    • Expression of active human cytochrome P450 1A2, NADPH-cytochrome P450 reductase, and N-acetyltransferase in Escherichia coli: Metabolic activation of aromatic amine mutagens
    • Josephy PD, Evans DH, Parikh A, Guengerich FP. 1998. Expression of active human cytochrome P450 1A2, NADPH-cytochrome P450 reductase, and N-acetyltransferase in Escherichia coli: metabolic activation of aromatic amine mutagens. Chem Res Toxicol 11:70-74.
    • (1998) Chem Res Toxicol , vol.11 , pp. 70-74
    • Josephy, P.D.1    Evans, D.H.2    Parikh, A.3    Guengerich, F.P.4
  • 67
    • 0030714011 scopus 로고    scopus 로고
    • Environment institute lays plans for gene hunt
    • Kaiser J. 1997. Environment institute lays plans for gene hunt. Science 278:569-570.
    • (1997) Science , vol.278 , pp. 569-570
    • Kaiser, J.1
  • 68
    • 0026598851 scopus 로고
    • Small intestinal cytochromes P450
    • Kaminsky LS, Fasco MJ. 1992. Small intestinal cytochromes P450. Crit Rev Toxicol 21:407-422.
    • (1992) Crit Rev Toxicol , vol.21 , pp. 407-422
    • Kaminsky, L.S.1    Fasco, M.J.2
  • 69
    • 0031015345 scopus 로고    scopus 로고
    • Human P450 metabolism of warfarin
    • Kaminsky LS, Zhang ZY. 1997. Human P450 metabolism of warfarin. Pharmacol Ther 73:67-74.
    • (1997) Pharmacol Ther , vol.73 , pp. 67-74
    • Kaminsky, L.S.1    Zhang, Z.Y.2
  • 70
    • 0027306807 scopus 로고
    • Regulation of steroid hydroxylase gene expression: Importance to physiology and disease
    • Keeney DS, Waterman MR. 1993. Regulation of steroid hydroxylase gene expression: importance to physiology and disease. Pharmacol Ther 58:301-317.
    • (1993) Pharmacol Ther , vol.58 , pp. 301-317
    • Keeney, D.S.1    Waterman, M.R.2
  • 71
    • 84977248846 scopus 로고
    • Über verwandlung der benzoesäure in hippursäure
    • Keller W. 1842. Über Verwandlung der Benzoesäure in Hippursäure. Annalen 43:108-111.
    • (1842) Annalen , vol.43 , pp. 108-111
    • Keller, W.1
  • 72
    • 0015623197 scopus 로고
    • Genetic variation of aryl hydrocarbon hydroxylase in human lymphocytes
    • Kellennan G, Luyten-Kellerman M, Shaw CR. 1973a. Genetic variation of aryl hydrocarbon hydroxylase in human lymphocytes. Am J Hum Genet 25:327-331.
    • (1973) Am J Hum Genet , vol.25 , pp. 327-331
    • Kellennan, G.1    Luyten-Kellerman, M.2    Shaw, C.R.3
  • 73
    • 0015682899 scopus 로고
    • Aryl hydrocarbon hydroxylase inducibility and bronchogenic carcinoma
    • Kellerman G, Shaw CR, Luyten-Kellerman M. 1973b. Aryl hydrocarbon hydroxylase inducibility and bronchogenic carcinoma. N Engl J Med 298:934-937.
    • (1973) N Engl J Med , vol.298 , pp. 934-937
    • Kellerman, G.1    Shaw, C.R.2    Luyten-Kellerman, M.3
  • 74
    • 0028298286 scopus 로고
    • Inhibition of terfenadine metabolism: Pharmacokinetic and pharmacodynamic consequences
    • Kivistö KT, Neuvonen PJ, Klotz U. 1994. Inhibition of terfenadine metabolism: pharmacokinetic and pharmacodynamic consequences. Clin Pharmacokinet 27:1-5.
    • (1994) Clin Pharmacokinet , vol.27 , pp. 1-5
    • Kivistö, K.T.1    Neuvonen, P.J.2    Klotz, U.3
  • 76
    • 0028051401 scopus 로고
    • The relevance of hepatic peroxisome proliferation in rats to assessment of human carcinogenic risk for pharmaceuticals
    • Kluwe WM. 1994. The relevance of hepatic peroxisome proliferation in rats to assessment of human carcinogenic risk for pharmaceuticals. Regul Toxicol Pharmacol 20:170-186.
    • (1994) Regul Toxicol Pharmacol , vol.20 , pp. 170-186
    • Kluwe, W.M.1
  • 77
    • 0025719746 scopus 로고
    • First-pass metabolism of cyclosporin by the gut
    • Kolars JC, Awni WM, Merion RM, Watkins PB. 1991. First-pass metabolism of cyclosporin by the gut. Lancet 338:1488-1490.
    • (1991) Lancet , vol.338 , pp. 1488-1490
    • Kolars, J.C.1    Awni, W.M.2    Merion, R.M.3    Watkins, P.B.4
  • 78
    • 0020385021 scopus 로고
    • Positive correlation between high aryl hydrocarbon hydroxylase activity and primary lung cancer as analyzed in cryopreserved lymphocytes
    • Kouri RE, McKinney CE, Slomiany DJ, Snodgrass DR, Wray NP, McLemore TL. 1982. Positive correlation between high aryl hydrocarbon hydroxylase activity and primary lung cancer as analyzed in cryopreserved lymphocytes. Cancer Res 42:5030-5037.
    • (1982) Cancer Res , vol.42 , pp. 5030-5037
    • Kouri, R.E.1    McKinney, C.E.2    Slomiany, D.J.3    Snodgrass, D.R.4    Wray, N.P.5    McLemore, T.L.6
  • 79
    • 0031748441 scopus 로고    scopus 로고
    • Expression of human cytochrome P450 1A2 in Escherichia coli: A system for biotransformation and genotoxicity studies of chemical carcinogens
    • Kranendonk M, Mesquita P, Laires A, Vermeulen NPE, Rueff J. 1998. Expression of human cytochrome P450 1A2 in Escherichia coli: a system for biotransformation and genotoxicity studies of chemical carcinogens. Mutagenesis 13:263-269.
    • (1998) Mutagenesis , vol.13 , pp. 263-269
    • Kranendonk, M.1    Mesquita, P.2    Laires, A.3    Vermeulen, N.P.E.4    Rueff, J.5
  • 80
    • 0027999623 scopus 로고
    • Rapid metabolic phenotypes for acetyltransferase and cytochrome P4501A2 and putative exposure to food-borne heterocyclic amines increase the risk for colorectal cancer or polyps
    • Lang NP, Butler MA, Massengill J, Lawson M, Stotts RC, MaurerJensen M, Kadlubar FF. 1994. Rapid metabolic phenotypes for acetyltransferase and cytochrome P4501A2 and putative exposure to food-borne heterocyclic amines increase the risk for colorectal cancer or polyps. Cancer Epidem Biomarker Prev 3:675-682.
    • (1994) Cancer Epidem Biomarker Prev , vol.3 , pp. 675-682
    • Lang, N.P.1    Butler, M.A.2    Massengill, J.3    Lawson, M.4    Stotts, R.C.5    Maurerjensen, M.6    Kadlubar, F.F.7
  • 81
    • 0012521143 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor α: Central mediator of peroxisome proliferator toxicity
    • Lapinskas PJ, Corton JC. 1997. Peroxisome proliferator-activated receptor α: central mediator of peroxisome proliferator toxicity. Chem Ind Inst Toxicol Activities 17:1-9.
    • (1997) Chem Ind Inst Toxicol Activities , vol.17 , pp. 1-9
    • Lapinskas, P.J.1    Corton, J.C.2
  • 82
    • 0032169485 scopus 로고    scopus 로고
    • The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions
    • Lehmann JM, McKee DD, Watson MA, Wilson TM, Moore JT, Kliewer SA. 1998. The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions. J Clin Invest 102:1016-1023.
    • (1998) J Clin Invest , vol.102 , pp. 1016-1023
    • Lehmann, J.M.1    McKee, D.D.2    Watson, M.A.3    Wilson, T.M.4    Moore, J.T.5    Kliewer, S.A.6
  • 83
    • 0031002895 scopus 로고    scopus 로고
    • A novel cytoplasmic protein that interacts with the Ah receptor, contains tetratricopeptide repeat motifs, and augments the transcriptional response to 2,3,7,8-tetrachlorodibenzo-p-dioxin
    • Ma Q, Whitlock JP Jr. 1997. A novel cytoplasmic protein that interacts with the Ah receptor, contains tetratricopeptide repeat motifs, and augments the transcriptional response to 2,3,7,8-tetrachlorodibenzo-p-dioxin. J Biol Chem 272:8878-8884.
    • (1997) J Biol Chem , vol.272 , pp. 8878-8884
    • Ma, Q.1    Whitlock J.P., Jr.2
  • 85
    • 0030995879 scopus 로고    scopus 로고
    • Molecular mechanisms of genetic polymorphisms of drug metabolism
    • Meyer UA, Zanger UM. 1997. Molecular mechanisms of genetic polymorphisms of drug metabolism. Annu Rev Pharmacol Toxicol 37:269-296.
    • (1997) Annu Rev Pharmacol Toxicol , vol.37 , pp. 269-296
    • Meyer, U.A.1    Zanger, U.M.2
  • 86
    • 84965819872 scopus 로고
    • The presence and significance of bound amino azodyes in the livers of rats fed p-dimethylaminoazobenzene
    • Miller EC, Miller JA. 1947. The presence and significance of bound amino azodyes in the livers of rats fed p-dimethylaminoazobenzene. Cancer Res 7:468-480.
    • (1947) Cancer Res , vol.7 , pp. 468-480
    • Miller, E.C.1    Miller, J.A.2
  • 88
    • 0001315679 scopus 로고
    • The metabolism of 4-dimethylaminoazobenzene by rat liver homogenates
    • Mueller GC, Miller JA. 1948. The metabolism of 4-dimethylaminoazobenzene by rat liver homogenates. J Biol Chem 176:535-544.
    • (1948) J Biol Chem , vol.176 , pp. 535-544
    • Mueller, G.C.1    Miller, J.A.2
  • 89
    • 0024829409 scopus 로고
    • The Ah locus: Genetic differences in toxicity, cancer, mutation, and birth defects
    • Nebert DW. 1989. The Ah locus: genetic differences in toxicity, cancer, mutation, and birth defects. Crit Rev Toxicol 20:153-174.
    • (1989) Crit Rev Toxicol , vol.20 , pp. 153-174
    • Nebert, D.W.1
  • 92
    • 0008905240 scopus 로고
    • Captoprilinduced agranulocytosis associated with an impairment of debrisoquine hydroxylation
    • Oates NS, Shah RR, Drury PL, Idle JR, Smith RL. 1982. Captoprilinduced agranulocytosis associated with an impairment of debrisoquine hydroxylation. Br J Pharmacol 14:601P.
    • (1982) Br J Pharmacol , vol.14
    • Oates, N.S.1    Shah, R.R.2    Drury, P.L.3    Idle, J.R.4    Smith, R.L.5
  • 93
    • 0029925074 scopus 로고    scopus 로고
    • A new Salmonella typhimurium NM5004 strain expressing rat glutathione S-transferase 5-5: Use in detection of genotoxicity of dihaloalkanes using an SOS/umu test system
    • Oda Y, Yamazaki H, Thier R, Ketterer B, Guengerich FP, Shimada T. 1996. A new Salmonella typhimurium NM5004 strain expressing rat glutathione S-transferase 5-5: use in detection of genotoxicity of dihaloalkanes using an SOS/umu test system. Carcinogenesis 17:297-302.
    • (1996) Carcinogenesis , vol.17 , pp. 297-302
    • Oda, Y.1    Yamazaki, H.2    Thier, R.3    Ketterer, B.4    Guengerich, F.P.5    Shimada, T.6
  • 96
    • 0033608962 scopus 로고    scopus 로고
    • Selection and characterization of human cytochrome P450 1A2 mutants with altered catalytic properties
    • Parikh A, Josephy PD, Guengerich FP. 1999. Selection and characterization of human cytochrome P450 1A2 mutants with altered catalytic properties. Biochemistry 38:5283-5289.
    • (1999) Biochemistry , vol.38 , pp. 5283-5289
    • Parikh, A.1    Josephy, P.D.2    Guengerich, F.P.3
  • 100
    • 0018801101 scopus 로고
    • The liver microsomal FAD-containing monooxygenase: Spectral characterization and kinetic studies
    • Poulsen LL, Ziegler DM. 1979. The liver microsomal FAD-containing monooxygenase: spectral characterization and kinetic studies. J Biol Chem 254:6449-6455.
    • (1979) J Biol Chem , vol.254 , pp. 6449-6455
    • Poulsen, L.L.1    Ziegler, D.M.2
  • 101
    • 0028935832 scopus 로고
    • Multisubstrate flavin-containing monooxygenases: Applications of mechanism to specificity
    • Poulsen LL, Ziegler DM. 1995. Multisubstrate flavin-containing monooxygenases: applications of mechanism to specificity. Chem Biol Interact 96:57-73.
    • (1995) Chem Biol Interact , vol.96 , pp. 57-73
    • Poulsen, L.L.1    Ziegler, D.M.2
  • 102
    • 0030935831 scopus 로고    scopus 로고
    • Genetic polymorphisms in human drug-metabolizing enzymes: Potential uses of reverse genetics to identify genes of toxicological relevance
    • Puga A, Nebert DW, McKinnon RA, Menon AG. 1997. Genetic polymorphisms in human drug-metabolizing enzymes: potential uses of reverse genetics to identify genes of toxicological relevance. Crit Rev Toxicol 27:199-222.
    • (1997) Crit Rev Toxicol , vol.27 , pp. 199-222
    • Puga, A.1    Nebert, D.W.2    McKinnon, R.A.3    Menon, A.G.4
  • 104
    • 34250951164 scopus 로고
    • The acceleration of evipan oxidation and the demethylation of methylaminopyrine by barbiturates
    • Remmer H. 1957. The acceleration of evipan oxidation and the demethylation of methylaminopyrine by barbiturates. Naunyn Schmiedebergs Arch Exp Pathol Pharmakol 237:296-307.
    • (1957) Naunyn Schmiedebergs Arch Exp Pathol Pharmakol , vol.237 , pp. 296-307
    • Remmer, H.1
  • 107
    • 0001400418 scopus 로고
    • Liver tumor inhibition and adrenal histologic responses in rats to which 3′-methyl-4-dimethylaminoazobenzene and 20-methylcholanthrene were simultaneously administered
    • Richardson HL, Stier AR, Borsos-Nachtnebel E. 1952. Liver tumor inhibition and adrenal histologic responses in rats to which 3′-methyl-4-dimethylaminoazobenzene and 20-methylcholanthrene were simultaneously administered. Cancer Res 12:356-361.
    • (1952) Cancer Res , vol.12 , pp. 356-361
    • Richardson, H.L.1    Stier, A.R.2    Borsos-Nachtnebel, E.3
  • 108
  • 109
    • 0029616617 scopus 로고
    • Interindividual variation in expression of P-glycoprotein in normal human liver and secondary hepatic neoplasms
    • Schuetz EG, Furuya KN, Schuetz JD. 1995. Interindividual variation in expression of P-glycoprotein in normal human liver and secondary hepatic neoplasms. J Pharmacol Exp Ther 275:1011-1018.
    • (1995) J Pharmacol Exp Ther , vol.275 , pp. 1011-1018
    • Schuetz, E.G.1    Furuya, K.N.2    Schuetz, J.D.3
  • 110
    • 0026049418 scopus 로고
    • Activation of amino-α-carboline, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine, and a copper phthalocyanine cellulose extract of cigarette smoke condensate by cytochrome P-450 enzymes in rat and human liver microsomes
    • Shimada T, Guengerich FP. 1991. Activation of amino-α-carboline, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine, and a copper phthalocyanine cellulose extract of cigarette smoke condensate by cytochrome P-450 enzymes in rat and human liver microsomes. Cancer Res 51:5284-5291.
    • (1991) Cancer Res , vol.51 , pp. 5284-5291
    • Shimada, T.1    Guengerich, F.P.2
  • 111
    • 0001477412 scopus 로고
    • SOS function tests for studies of chemical carcinogenesis in Salmonella typhimurium TA 1535/pSK1002, NM2009, and NM30009
    • Adolph KW, editor. Orlando, FL: Academic Press
    • Shimada T, Oda Y, Yamazaki H, Mimura M, Guengerich FP. 1994. SOS function tests for studies of chemical carcinogenesis in Salmonella typhimurium TA 1535/pSK1002, NM2009, and NM30009. In: Adolph KW, editor. Methods in molecular genetics, vol. 5. Gene and chromosome analysis. Orlando, FL: Academic Press. p 342-355.
    • (1994) Methods in Molecular Genetics, Vol. 5. Gene and Chromosome Analysis , vol.5 , pp. 342-355
    • Shimada, T.1    Oda, Y.2    Yamazaki, H.3    Mimura, M.4    Guengerich, F.P.5
  • 112
    • 0027333091 scopus 로고
    • Increased mutagenicity of 1,2-dibromo-3-chloropropane and tris(2,3-dibromopropyl)phosphate in Salmonella TA100 expressing human glutathione S-transferases
    • Simula TP, Glancey MJ, Söderlund EJ, Dybing E, Wolf CR. 1993a. Increased mutagenicity of 1,2-dibromo-3-chloropropane and tris(2,3-dibromopropyl)phosphate in Salmonella TA100 expressing human glutathione S-transferases. Carcinogenesis 14:2303-2307.
    • (1993) Carcinogenesis , vol.14 , pp. 2303-2307
    • Simula, T.P.1    Glancey, M.J.2    Söderlund, E.J.3    Dybing, E.4    Wolf, C.R.5
  • 113
    • 0027169566 scopus 로고
    • Human glutathione S-transferase-expressing Salmonella typhimurium tester strains to study the activation/detoxification of mutagenic compounds: Studies with halogenated compounds, aromatic amines and aflatoxin B1
    • Simula TP, Glancey MJ, Wolf CR. 1993b. Human glutathione S-transferase-expressing Salmonella typhimurium tester strains to study the activation/detoxification of mutagenic compounds: studies with halogenated compounds, aromatic amines and aflatoxin B1. Carcinogenesis 14:1371-1376.
    • (1993) Carcinogenesis , vol.14 , pp. 1371-1376
    • Simula, T.P.1    Glancey, M.J.2    Wolf, C.R.3
  • 114
    • 0018278763 scopus 로고
    • Genetically determined defects of oxidation at carbon centres of drugs
    • Smith RL, Idle JR, Mahgoub AA, Sloan TP, Lancaster R. 1978. Genetically determined defects of oxidation at carbon centres of drugs. Lancet i:943-944.
    • (1978) Lancet , vol.1 , pp. 943-944
    • Smith, R.L.1    Idle, J.R.2    Mahgoub, A.A.3    Sloan, T.P.4    Lancaster, R.5
  • 116
    • 4244171512 scopus 로고    scopus 로고
    • Uncertain climate tor antihistamines
    • Stinson SC. 1997. Uncertain climate tor antihistamines. Chem Eng News 75:43-45.
    • (1997) Chem Eng News , vol.75 , pp. 43-45
    • Stinson, S.C.1
  • 118
    • 7844247934 scopus 로고    scopus 로고
    • Comparisons between in-vitro and in-vivo metabolism of (S)-warfarin: Catalytic activities of cDNA-expressed CYP2C9, its Leu359 variant and their mixture versus unbound clearance in patients with the corresponding CYP2C9 genotypes
    • Takahashi H, Kashima T, Nomoto S, Iwade K, Tainaka H, Shimizu T, Nomizo Y, Muramoto N, Kimura S, Echizen H. 1998. Comparisons between in-vitro and in-vivo metabolism of (S)-warfarin: catalytic activities of cDNA-expressed CYP2C9, its Leu359 variant and their mixture versus unbound clearance in patients with the corresponding CYP2C9 genotypes. Pharmacogenetics 8:365-373.
    • (1998) Pharmacogenetics , vol.8 , pp. 365-373
    • Takahashi, H.1    Kashima, T.2    Nomoto, S.3    Iwade, K.4    Tainaka, H.5    Shimizu, T.6    Nomizo, Y.7    Muramoto, N.8    Kimura, S.9    Echizen, H.10
  • 119
    • 0027321555 scopus 로고
    • Expression of mammalian glutathione S-transferase 5-5 in Salmonella typhimurium TA1535 leads to base-pair mutations upon exposure to dihalomethanes
    • Thier R, Pemble SE, Taylor JB, Humphreys WG, Persmark M, Ketterer B, Guengerich FP. 1993. Expression of mammalian glutathione S-transferase 5-5 in Salmonella typhimurium TA1535 leads to base-pair mutations upon exposure to dihalomethanes. Proc Natl Acad Sci USA 90:8576-8580.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 8576-8580
    • Thier, R.1    Pemble, S.E.2    Taylor, J.B.3    Humphreys, W.G.4    Persmark, M.5    Ketterer, B.6    Guengerich, F.P.7
  • 121
    • 0029911205 scopus 로고    scopus 로고
    • The catalytic mechanism of microsomal epoxide hydrolase involves reversible formation and rate-limiting hydrolysis of the alkyl-enzyme intermediate
    • Tzeng H-F, Laughlin LT, Lin S, Armstrong RN. 1996. The catalytic mechanism of microsomal epoxide hydrolase involves reversible formation and rate-limiting hydrolysis of the alkyl-enzyme intermediate. J Am Chem Soc 118:9436-9437.
    • (1996) J Am Chem Soc , vol.118 , pp. 9436-9437
    • Tzeng, H.-F.1    Laughlin, L.T.2    Lin, S.3    Armstrong, R.N.4
  • 122
    • 0029028792 scopus 로고
    • Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P-glycoprotein: Implications for drug delivery and activity in cancer chemotherapy
    • Wacher VJ, Wu CY, Benet LZ. 1995. Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P-glycoprotein: implications for drug delivery and activity in cancer chemotherapy. Mol Carcinogen 13:129-134.
    • (1995) Mol Carcinogen , vol.13 , pp. 129-134
    • Wacher, V.J.1    Wu, C.Y.2    Benet, L.Z.3
  • 125
    • 0029938015 scopus 로고    scopus 로고
    • A semi-automated, microplate version of the SOS chromotest for the analysis of complex environmental extracts
    • White PA, Rasmussen JB, Blaise C. 1996. A semi-automated, microplate version of the SOS chromotest for the analysis of complex environmental extracts. Mutat Res 360:51-74.
    • (1996) Mutat Res , vol.360 , pp. 51-74
    • White, P.A.1    Rasmussen, J.B.2    Blaise, C.3
  • 127
    • 0027474601 scopus 로고
    • Mechanism of the cardiotoxic actions of terfenadine
    • Woosley RL, Chen Y, Freiman JP, Gillis RA. 1993. Mechanism of the cardiotoxic actions of terfenadine. JAMA 269:1532-1536.
    • (1993) JAMA , vol.269 , pp. 1532-1536
    • Woosley, R.L.1    Chen, Y.2    Freiman, J.P.3    Gillis, R.A.4
  • 128
    • 0032934961 scopus 로고    scopus 로고
    • Genetic polymorphisms of human N-acetyltransferase, cytochrome P450, glutathione-S-transferase, and epoxide hydrolase enzymes: Relevance to xenobiotic metabolism and toxicity
    • Wormhoudt LW, Commandeur JNM, Vermeulen NPE. 1999 Genetic polymorphisms of human N-acetyltransferase, cytochrome P450, glutathione-S-transferase, and epoxide hydrolase enzymes: relevance to xenobiotic metabolism and toxicity. Crit Rev Toxicol 29:59-124.
    • (1999) Crit Rev Toxicol , vol.29 , pp. 59-124
    • Wormhoudt, L.W.1    Commandeur, J.N.M.2    Vermeulen, N.P.E.3
  • 129
    • 0026750647 scopus 로고
    • The human hepatic cytochromes P450 involved in drug metabolism
    • Wrightom SA, Stevens JC. 1992. The human hepatic cytochromes P450 involved in drug metabolism. Crit Rev Toxicol 22:1-21.
    • (1992) Crit Rev Toxicol , vol.22 , pp. 1-21
    • Wrightom, S.A.1    Stevens, J.C.2
  • 131
    • 0031757521 scopus 로고    scopus 로고
    • Comparative studies on the catalytic roles of cytochrome P450 2C9 and its Cys- and Leu-variants in the oxidations of warfarin, flurbiprofen, and diclofenac by human liver microsomes
    • Yamazaki H, Inoue K, Chiba K, Ozawa N, Kawai T, Suzuki Y, Goldstein JA, Guengerich FP, Shimada T. 1998. Comparative studies on the catalytic roles of cytochrome P450 2C9 and its Cys- and Leu-variants in the oxidations of warfarin, flurbiprofen, and diclofenac by human liver microsomes. Biochem Pharmacol 56:243-251.
    • (1998) Biochem Pharmacol , vol.56 , pp. 243-251
    • Yamazaki, H.1    Inoue, K.2    Chiba, K.3    Ozawa, N.4    Kawai, T.5    Suzuki, Y.6    Goldstein, J.A.7    Guengerich, F.P.8    Shimada, T.9
  • 132
    • 0027168405 scopus 로고
    • Oxidation of the antihistaminic drug terfenadine in human liver microsomes: Role of cytochrome P450 3A(4)in N-dealkylation and C-hydroxylation
    • Yun C-H, Okerholm RA, Guengerich FP. 1993. Oxidation of the antihistaminic drug terfenadine in human liver microsomes: role of cytochrome P450 3A(4)in N-dealkylation and C-hydroxylation. Drug Metab Disp 21:403-409.
    • (1993) Drug Metab Disp , vol.21 , pp. 403-409
    • Yun, C.-H.1    Okerholm, R.A.2    Guengerich, F.P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.