Dimyristoylphosphatidylcholine/C16:0-ceramide binary liposomes studied by differential scanning calorimetry and wide- and small-angle X-ray scattering

Biophysical Journal

Volumn 78, Issue 5, 2000, Pages 2459-2469

  Holopainen, Juha M ^a   Lemmich, Jesper ^b   Richter, Frank ^c,d   Mouritsen, Ole G ^b   Rapp, Gert ^c   Kinnunen, Paavo K J ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

^b TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

^c EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

^d TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CERAMIDE; DIMYRISTOYLPHOSPHATIDYLCHOLINE; LIPOSOME;

ARTICLE; BILAYER MEMBRANE; CALORIMETRY; CELL MEMBRANE; DIFFERENTIAL SCANNING CALORIMETRY; ENTHALPY; LIPID MEMBRANE; MEMBRANE MODEL; X RAY DIFFRACTION;

EID: 0034105994     PISSN: 00063495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3495(00)76790-7     Document Type: Article

References (49)

1. Bar, L. K., Y. Barenholz, and T. E. Thompson. 1997. Effect of sphingomyelin composition on the phase structure of phosphatidylcholine-sphingomyelin bilayers. Biochemistry. 36:2507-2516.
2. Basáñez, G., M. B. Ruiz-Argüello, A. Alonso, F. M. Gon̈i, G. Karlsson, and K. Edwards. 1997. Morphological changes induced by phospholipase C and by sphingomyelinase on large unilamellar vesicles: a cryo-transmission electron microscopy study of liposome fusion. Biophys, J. 72:2630-2637.
3. Blume, A., R. J. Wittebort, S. K. Das Gupta, and R. G. Griffin. 1982. Phase equilibria, molecular conformation, and dynamics in phosphatidylcholine/phosphatidylethanolamine bilayers. Biochemistry. 21:6243-6253.
4. Buboltz, J. T., and G. W. Feigenson. 1999. A novel strategy for the preparation of liposomes: rapid solvent exchange. Biochim. Biophys. Acta. 1417:232-245.
5. Calhoun, W. I., and G. G. Shipley. 1979. Sphingomyelin-lecithin bilayers and their interaction with cholesterol. Biochemistry. 18:1717-1722.
6. Chao, W., and M. S. Olson. 1993. Platelet activating factor: receptors and signal transduction. Biochem. J. 292:617-629.
7. Elias, P. M., and G. K. Menon. 1991. Structural and lipid biochemical correlates of the epidermal permeability barrier. Adv. Lipid Res. 24:1-26.
8. Gómez-Muñoz, A. 1998. Modulation of cell signalling by ceramides. Biochim. Biophys. Acta. 1391:92-109.
9. Han, C. H., R. Sanftleben, and T. S. Wiedmann. 1995. Phase properties of mixtures of ceramides. Lipids. 30:121-128.
10. Hannun, Y. A. 1994. The sphingomyelin cycle and the second messenger function of ceramide. J. Biol. Chem. 269:3125-3128.
11. Hannun, Y. A. 1996. Functions of ceramide in coordinating cellular responses to stress. Science. 274:1855-1859.
12. Hannun, Y. A., and L. M. Obeid. 1995. Ceramide: an intracellular signal for apoptosis. Trends Biol. Sci. 20:73-77.
13. Helfrich, W. 1978. Steric interactions of fluid membranes in multilayer systems. Z. Naturforsch. 33a:305-315.
14. Hinderliter, A. K., A. R. G. Dibble, R. L. Biltonen, and J. J. Sando. 1997. Activation of protein kinase C by coexisting diacylglycerol-enriched and diacylglycerol-poor lipid domains. Biochemistry. 36:6141-6148.
15. Holopainen, J. M., M. I. Angelova, and P. K. J. Kinnunen. 2000. Vectorial budding of vesicles by asymmetric enzymatic formation of ceramide in giant liposomes. Biophys. J. 78:830-838.
16. Holopainen, J. M., J. Y. A. Lehtonen, and P. K. J. Kinnunen. 1997. Lipid microdomains in dimyristoylphosphatidylcholine-ceramide liposomes. Chem. Phys. Lipids. 88:1-13.
17. Holopainen, J. M., M. Subramanian, and P. K. J. Kinnunen. 1998. Sphingomyelinase induced lipid microdomain formation in a fluid phosphatidylcholine/sphingomyelin membrane. Biochemistry. 37:17562-17570.
18. 2 activity and dynamic lipid bilayer microheterogeneity. Biochemistry. 35:9003-9006.
19. Hønger, T., K. Mortensen, J. H. Ipsen, J. Lemmich, R. Bauer, and O. G. Mouritsen. 1994. Anomalous swelling of multilamellar lipid bilayers in the transition region by renormalization of curvature elasticity. Phys. Rev. Lett. 72:3911-3914.
20. 2. Biochem. Biophys. Res. Commun. 222:834-838.
21. Huang, J., J. T. Buboltz, and G. W. Feigenson. 1999. Maximum solubility of cholesterol in phosphatidylcholine and phosphatidylethanolamine bilayers. Biochim. Biophys. Acta. 1417:89-100.
22. Ipsen, J. H., K. Jørgensen, and O. G. Mouritsen. 1990. Density fluctuations in saturated phospholipid bilayers increase as the chain-length decreases. Biophys. J. 58:1099-1107.
23. Izumi, T., and T. Shimizu. 1995. Platelet-activating factor receptor: gene expression and signal transduction. Biochim. Biophys. Acta. 1259:317-333.
24. Jørgensen, K., A. Klinger, M. Braiman, and R. L. Biltonen. 1996. Slow nonequilibrium dynamical rearrangement of the lateral structure of a lipid membrane. J. Phys. Chem 100:2766-2769.
25. Jutila, A., and P. K. J. Kinnunen. 1997. Novel features of the main transition of dimyristoylphosphocholine bilayers revealed by fluorescence spectroscopy. J. Phys. Chem. B. 101:7635-7640.
26. Kinnunen, P. K. J. 1991. On the principles of functional ordering in biological membranes. Chem. Phys. Lipids. 57:375-399.
27. Lehtonen, J. Y. A., J. M. Holopainen, and P. K. J. Kinnunen. 1996. Evidence for the formation of microdomains in liquid crystalline large unilamellar vesicles caused by hydrophobic mismatch of the constituent phospholipids. Biophys. J. 70:1753-1760.
28. Lemmich, J., T. Hønger, K. Mortensen, J. H. Ipsen, R. Bauer, and O. G. Mouritsen. 1996. Solutes in small amounts provide for lipid-bilayer softness: cholesterol, short-chain lipids, and bola lipids. Eur. Biophys. J. 25:61-65.
29. Liu, P., and R. G. Anderson. 1995. Compartmentalized production of ceramide at the cell surface. J. Biol. Chem. 270:27179-27185.
30. McElhaney, R. N. 1982. The use of differential scanning calorimetry and differential thermal analysis of model and biological membranes. Chem. Phys. Lipids. 30:229-259.
31. McKeone, B. J., H. J. Pownall, and J. B. Massey. 1986. Ether phosphatidylcholines: comparison of miscibility with ester phosphatidylcholines and sphingomyelin, vesicle fusion, and association with apolipoprotein A-I. Biochemistry. 25:7711-7716.
32. Moore, D. J., M. E. Rerek, and R. Mendelsohn. 1997. FTIR spectroscopy studies of the conformational order and phase behaviour of ceramides. J. Phys. Chem. B. 101:8933-8940.
33. Mouritsen, O. G., and P. K. J. Kinnunen. 1996. Role of lipid organization and dynamics for membrane functionality. In Biological Membranes. K. Merz and B. Roux, editors. Birkhäuser, Boston. 463-502.
34. Mustonen, P., J. A. Virtanen, P. J. Somerharju, and P. K. J. Kinnunen. 1987. Binding of cytochrome c to liposomes as revealed by the quenching of fluorescence from pyrene-labeled phospholipids. Biochemistry. 26:2991-2997.
35. Pascher, I. 1976. Molecular arrangements in sphingolipids. Conformation and hydrogen bonding of ceramide and their implication on membrane stability and permeability. Biochim. Biophys. Acta. 455:433-451.
36. Rapp, G. 1992. Time-resolved x-ray diffraction studies on biological systems. Acta Phys. Pol. A82:103-120.
37. Rapp, G., A. Gabriel, M. Dosiere, and M. H. J. Koch. 1995. A dual detector single readout system for simultaneous small- (SAXS) and wide-angle (WAXS) scattering. Nucl. Instrum. Methods A. 357:178-182
38. Rappolt, M., and G. Rapp. 1996a. Simultaneous small- and wide-angle x-ray diffraction during the main transition of dimyristoylphosphati-dylethanolamine. Ber. Bunsenges. Phys. Chem. 100:1153-1162
39. Rappolt, M., and G. Rapp. 1996b. Structure of the stable and metastable ripple phase of dipalmitoylphosphatidylcholine. Eur. Biophys. J. 24:381-386.
40. Ruiz-Argüello, M. B., G. Basáñez, F. M. Gon̈i, and A. Alonso. 1996. Different effects of enzyme-generated ceramides and diacylglycerols in phospholipid membrane fusion and leakage. J. Biol. Chem. 271:26616-26621.
41. Shah, J., J. M. Atienza, R. I. Duclos, Jr., A. V. Rawlings, Z. Dong, and G. G. Shipley. 1995a. Structural and thermotropic properties of synthetic C16:0 (palmitoyl) ceramide: effect of hydration. J. Lipid Res. 36:1936-1944.
42. Shah, J., J. M. Atienza, A. V. Rawlings, and G. G. Shipley. 1995b. Physical properties of ceramides: effect of fatty acid hydroxylation. J. Lipid Res. 36:1945-1955.
43. Silvius, J. R. 1982. Thermotropic phase transitions of pure lipids in model membranes and their modifications by membrane proteins. In Lipid-Protein Interactions, Vol. 2. P. C. Jost and O. H. Griffith, editors. John Wiley and Sons, New York. 239-281.
44. Smart, E. J., G. A. Graf, M. A. McNiven, W. C. Sessa, J. A. Engelman, P. E. Scherer, T. Okamoto, and M. P. Lisanti. 1999. Caveolins, liquid-ordered domains, and signal transduction. Mol. Cell. Biol. 19:7289-7304.
45. Thomas, R. L., Jr., C. M. Matsko, M. T. Lotze, and A. A. Amoscato. 1999. Mass spectrometric identification of increased C16 ceramide levels during apoptosis. J. Biol. Chem. 274:30580-30588.
46. Thompson, T. E., M. Allietta, R. E. Brown, M. L. Johnson, and T. W. Tillack. 1985. Organization of ganglioside GM, in phosphatidylcholine bilayers. Biochim. Biophys. Acta. 817:229-237.
47. Voet, D., and J. G. Voet. 1995. Lipid metabolism. In Biochemistry. John Wiley and Sons, Somerset, NJ. 662-726.
48. Weis, R. M. 1991. Fluorescence microscopy of phospholipid monolayer phase transitions. Chem. Phys. Lipids. 57:227-239.
49. Weis, R. M., and H. M. McConnell. 1985. Cholesterol stabilizes the crystal-liquid interface in phospholipid monolayers. J. Phys. Chem. 89:4453-4459.