The effect of particle morphology on the physical stability of pharmaceutical powder mixtures: The effect of surface roughness of the carrier on the stability of ordered mixtures

Drug Development and Industrial Pharmacy

Volumn 26, Issue 4, 2000, Pages 365-373

  Swaminathan, Vidya ^a,b   Kildsig, Dane O ^a  

^a PURDUE UNIVERSITY   (United States)

^b GLAXOSMITHKLINE   (United States)

Author keywords

Mixture stability; Particle morphology; Roughness; Surface texture

Indexed keywords

ACETYLSALICYLIC ACID; DRUG CARRIER; EMDEX; LACTOSE; MAGNESIUM STEARATE; MICROCRYSTALLINE CELLULOSE;

ADHESION; ARTICLE; CONTROLLED STUDY; DRUG MIXTURE; DRUG STABILITY; ELECTRICITY; ENERGY; MODEL; MORPHOLOGY; PARTICLE SIZE; POWDER; SURFACE PROPERTY;

CHEMISTRY, PHARMACEUTICAL; PARTICLE SIZE; PHARMACEUTICAL PREPARATIONS; POWDERS; SURFACE PROPERTIES;

EID: 0034105206     PISSN: 03639045     EISSN: None     Source Type: Journal    
DOI: 10.1081/DDC-100101242     Document Type: Article

References (8)

1. J. A. Hersey, Powder Technol., 11, 41-44 (1975).
2. J. A. Hersey, in Particle Characterization in Technology, Vol. 1 (J. K. Beddow, Ed.), CRC Press, Boca Raton, FL, 1984, p. 75.
3. Y. Padmadisastra, R. A. Kennedy, and P. J. Stewart, Int. J. Pharm., 112, 55-63 (1994).
4. J. K. Beddow and T. Meloy, Testing and Characterization of Powders and Fine Particles, Heyden and Son, Ltd., 1980, pp. 88-90.
5. P. J. Stewart, Drug Dev. Ind. Pharm., 7(5), 485-495 (1981).
6. J. K. Staniforth, J. Pharm. Pharmacol., 34, 141-145 (1982).
7. J. N. Staniforth and J. E. Rees, J. Pharm. Pharmacol., 34, 69-76 (1982).
8. E. N. Heistand, Mechanics and Physical Principles for Powders and Compacts, Author, Galesburg, MI, 1991.