LRP-DIT, a putative endocytic receptor gene, is frequently inactivated in non-small cell lung cancer cell lines

Cancer Research

Volumn 60, Issue 7, 2000, Pages 1961-1967

  Liu, Chun Xiang ^a   Musco, Simone ^a   Lisitsina, Natalia M ^a   Forgacs, Eva ^b   Minna, John D ^b   Lisitsyn, Nikolai A ^a,c  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT; LIPOPROTEIN RECEPTOR RELATED PROTEIN DELETED IN TUMORS; UNCLASSIFIED DRUG;

ARTICLE; ENDOCYTOSIS; GENE DELETION; GENE INACTIVATION; HUMAN; HUMAN CELL; LUNG NON SMALL CELL CANCER; MISSENSE MUTATION; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE;

AMINO ACID SEQUENCE; BASE SEQUENCE; CARCINOMA, NON-SMALL-CELL LUNG; CHROMOSOME MAPPING; CHROMOSOMES, HUMAN, PAIR 2; CODON; ENDOCYTOSIS; GENE DELETION; GENES, TUMOR SUPPRESSOR; GENETIC MARKERS; HOMOZYGOTE; HUMANS; LDL-RECEPTOR RELATED PROTEIN 1; LUNG NEOPLASMS; MOLECULAR SEQUENCE DATA; MUTATION, MISSENSE; OPEN READING FRAMES; RECEPTORS, IMMUNOLOGIC; TUMOR CELLS, CULTURED;

EID: 0034105201     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. Fidler, I. J., and Hart, I. R. Biological diversity in metastatic neoplasms: origins and implications. Science (Washington DC), 217: 998-1003, 1982.
2. Tamura, G., Sakata, K., Nishizuka, S., Maesawa, C., Suzuki, Y., Terashima, M., Eda, Y., and Satodate, R. Allelotype of adenoma and differentiated adenocarcinoma of the stomach. J. Pathol., 180: 371-377, 1996.
3. Richter, J., Jiamg, F., Gorog, J., Sartorius, G., Egenter, C., Gasser, T. C., Moch, H., Mihatsch, M. H., and Sauter, G. Marked genetic differences between stage pTa and stage pT1 papillary bladder cancer detected by comparative genomic hybridization. Cancer Res., 57: 2860-2864, 1997.
4. Shiseki, M., Kohno, T., Nishikawa, R., Sameshima, Y., Mizoguchi, H., and Yokota, J. Frequent allelic losses on chromosomes 2q, 18q, and 22q in advanced non-small cell lung carcinoma. Cancer Res., 54: 5643-5648, 1994.
5. Ransom, D. T., Bamett, T. C., Bot, J., de Boer, B., Metcalf, C., Davidson, J. A., and Tarbett, J. R. Loss of heterozygosity on chromosome 2q: possibly a poor prognostic factor in head and neck cancer. Head Neck, 20: 404-410, 1998.
6. Friend, S. H., Bernards, R., Rogelj, S., Weinberg, R. A., Rapaport, J. M., Albert, D. M., and Dryja, T. P. A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma. Nature (Lond.), 323: 643-646, 1986.
7. Li, J., Yen, C., Liaw, D., Podsypanina, K., Bose, S., Wang, S. I., Puc, J., Miliaresis, C., Rodgers, L., McCombie, R., Bigner, S. H., Giovanella, B. C., Ittman, M., Tycko, B., Hibshoosh, H., Wigler, M. H., and Parsons, R. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science (Washington DC), 275: 1943-1947, 1997.
8. Schutte, M., da Costa, L. T., Hahn, S. A., Moskaluk, C. A., Hoque, A. T. M. S., Rozenblum, E., Weinstein, C. L., Bittner, M., Meltzer, P. S., Trent, J. M., Yeo, C. J., Hruban, R. H., and Kern, S. E. Identification by representational difference analysis of a homozygous deletion in pancreatic carcinoma that lies within the BRCA2 region. Proc. Natl. Acad. Sci. USA, 92: 5950-5954, 1995.
9. Kamb, A., Gruis, N. A., Weaver-Felghaus, J., Liu, Q., Harshman, K., Tavtigian, S. V., Stockert, E., Day, R. S., Johnson, B. E., and Skolnick, M. H. A cell cycle regulator potentially involved in genesis of many tumor types. Science (Washington DC), 264: 436-440, 1994.
10. Hahn, S. A., Schutte, M., Hoque, A. T. M. S., Moskaluk, C. A., da Costa, L. T., Rosenblum, E., Weinstein, C. L., Fisher, A., Yeo, C. J., Hruban, R. H., and Kern, S. E. DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1. Science (Washington DC), 271: 350-353, 1996.
11. Lisitsyn, N. A., Lisitsina, N. M., Galbagni, J., Barker, P., Sanchez, C. A., Gnarra, J., Linchan, W. M., Reid, B. J., and Wigler, M. H. Comparative genomic analysis of tumors: detection of DNA losses and amplification. Proc. Natl. Acad. Sci. USA, 92: 151-155, 1995.
12. Brown, M. S., Herz, J., and Goldstein, J. L. LDL-receptor structure. Calcium cages, acid baths and recycling receptors. Nature (Lond.), 388: 629-630, 1997.
13. Wu, W., Kemp, B. L., Proctor, M. L., Gazdar, A. F., Minna, J. D., Hong, W. K., and Mao, L. Expression of DMBT1, a candidate tumor suppressor gene, is frequently lost in lung cancer. Cancer Res., 59: 1846-1851, 1999.
14. Trommsdorff, M., Borg, J., Margolis, B., and Herz, J. Interaction of cytosolic adaptor proteins with neuronal apolipoprotein E receptors and the amyloid precursor protein. J. Biol. Chem., 273: 33556-33560, 1998.
15. Goldstein, J. L., Hobbs, H. H., and Brown, M. S. Chapter 62. In: C. R. Scriver, A. L. Beaudet, W. S. Sly, and D. Valle. The Metabolic and Molecular Bases of Inherited Disease, Ed. 7, pp. 1953-1980. New York: McGraw-Hill, 1995.
16. Kounnas, M. Z., Stefansson, S., Loukinova, E., Agraves, K. M., Strickland, D. K., and Agraves, W. S. An overview of the structure and function of glycoprotein 330, a receptor related to the α2-macroglobulin receptor. Annals NY Acad. Sci., 737: 114-123, 1994.
17. Andreasen, P. A., Kjoller, L., Christensen, L., and Duffy, M. J. The urokinase-type plasminogen activator system in cancer metastasis: a review. Int. J. Cancer, 72: 1-22, 1997.