Randomized comparison of ACVBP and m-BACOD in the treatment of patients with low-risk aggressive lymphoma: The LNH87-1 study

Journal of Clinical Oncology

Volumn 18, Issue 6, 2000, Pages 1309-1315

  Tilly, Hervé ^a   Mounier, Nicolas ^a   Lederlin, Pierre ^a   Brière, Josette ^a   Dupriez, Brigitte ^a   Sebban, Catherine ^a   Bosly, André ^a   Biron, Pierre ^a   Nouvel, Catherine ^a   Herbrecht, Raoul ^a   Bordessoule, Dominique ^a   Coiffier, Bertrand ^a  

^a UNIVERSITY HOSPITAL OF MONT GODINNE   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

BLEOMYCIN; CYCLOPHOSPHAMIDE; DOXORUBICIN; ETOPOSIDE; METHOTREXATE; PREDNISONE; VINDESINE;

ADOLESCENT; ADULT; AGED; ARTICLE; CANCER COMBINATION CHEMOTHERAPY; CANCER REGRESSION; CANCER RISK; CANCER SURVIVAL; DRUG EFFICACY; FEMALE; HUMAN; LUNG TOXICITY; LYMPHOMA; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RISK BENEFIT ANALYSIS; TREATMENT OUTCOME;

EID: 0034104325     PISSN: 0732183X     EISSN: None     Source Type: Journal    
DOI: 10.1200/JCO.2000.18.6.1309     Document Type: Article

References (34)

1. Gordon LI, Harrington D, Andersen J, et al: Comparison of a second-generation chemotherapeutic regimen (m-BACOD) with a standard regimen (CHOP) for advanced diffuse non-Hodgkin's lymphoma. N Engl J Med 327:1342-1349, 1992
2. Fisher RI, Gaynor ER, Dahlberg S, et al: Comparison of a standard regimen (CHOP) with three intensive chemotherapy regimens for advanced non-Hodgkin's lymphoma. N Engl J Med 328:1002-1006, 1993
3. Cooper IA, Wolf MM, Robertson TI, et al: Randomized comparison of MACOP-B with CHOP in patients with intermediate grade non-Hodgkin's lymphoma. J Clin Oncol 12:769-778, 1995
4. Freedman AS, Takvorian T, Neuberg D, et al: Autologous bone marrow transplantation as consolidation therapy for non-Hodgkin's lymphoma in first remission: A pilot study. J Clin Oncol 11:931-936, 1993
5. Haioun C, Lepage E, Gisselbrecht C, et al: Benefit of autologous bone marrow transplantation over sequential chemotherapy in poor-risk aggressive non-Hodgkin's lymphoma: Updated results of the prospective study LNH87-2. J Clin Oncol 15:1131-1137, 1997
6. Gianni AM, Bregni M, Siena S, et al: High-dose chemotherapy and autologous bone marrow transplantation compared with MACOP-B in aggressive B-cell lymphoma. N Engl J Med 336:1290-1295, 1997
7. Coiffier B, Bryon PA, Ffrench M, et al: Intensive chemotherapy in aggressive lymphoma: Updated results of LNH-80 protocol and prognostic factors affecting response and survival. Blood 70:1394-1399, 1987
8. Coiffier B: Fourteen years of high-dose CHOP (ACVBP regimen): Preliminary conclusions about the treatment of aggressive lymphoma patients. Ann Oncol 6:211-217, 1995
9. Coiffier B, Gisselbrecht C, Herbrecht R, et al: A multicenter study of intensive chemotherapy in 737 patients with aggressive malignant lymphoma. J Clin Oncol 7:1018-1026, 1989
10. Bosly A, Lepage E, Coiffier B, et al: In elderly patients with non-Hodgkin's lymphoma, alternance of chemotherapy is not superior to ACVBP + consolidation: A prospective randomized study on 884 patients - LNH87 protocol group 3. Ann Oncol 7:60, 1996 (suppl 3, abstr)
11. Non-Hodgkin's lymphoma Classification Project: National Cancer Institute sponsored study of classification of non-Hodgkin's lymphoma: Summary and description of a working formulation for clinical usage. Cancer 49:2112-2135, 1982
12. Oken MM, Creech RH, Tormey DC, et al: Toxicity and response criteria of the Eastern Cooperative Oncology Group. Am J Clin Oncol 5:649-655, 1982
13. Stansfeld AG, Diebold J, Noel H, et al: Updated Kiel classification for lymphomas. Lancet 1:292-293, 1988 (letter; published erratum appears in Lancet 1:372, 1988)
14. Tilly H, Gaulard P, Lepage E, et al: Primary anaplastic large-cell lymphoma in adults: Clinical presentation, immunophenotype and outcome. Blood 90:3727-3734, 1997
15. Haioun C, Lepage E, Gisselbrecht C, et al: Comparison of autologous bone marrow transplantation with sequential chemotherapy for intermediate-grade and high-grade non-Hodgkin's lymphoma in first complete remission: A study of 464 patients. J Clin Oncol 12:2543-2551, 1994
16. Shipp MA, Harrington DP, Klatt MM, et al: Identification of major prognostic subgroups in patients with large-cell lymphoma treated with m-BACOD or m-BACOD. Ann Intern Med 104:757-765, 1986
17. Bastion Y, Blay JY, Divine M, et al: Elderly patients with aggressive non-Hodgkin's lymphoma: Disease presentation, response to treatment and survival - A Groupe d'Etude des Lymphomes de l'Adulte study on 453 patients older than 69 years. J Clin Oncol 15:2945-2953, 1997
18. Cheson BD, Horning SJ, Coiffier B, et al: Report of an international workshop to standardize response criteria for non-Hodgkin's lymphoma. J Clin Oncol 17:1244-1253, 1999
19. Freeman DH: Applied categorical data analysis, in Statistics: Text-Books and Monographs, Vol 79. New York, NY, Marcel Dekker, 1987
20. Kaplan EL, Meier P: Nonparametric estimation for incomplete observations. J Am Stat Assoc 53:457-481, 1958
21. Mantel N: Evaluation of survival data and two new rank order statistics arising in its consideration. Cancer Chemother Rep 50:163-170, 1966
22. The International Non-Hodgkin's Lymphoma Prognostic Factors Project: A predictive model for aggressive non-Hodgkin's lymphoma. N Engl J Med 329:987-994, 1993
23. Cox DR: Regression model and life tables. J R Stat Soc B 34:187-220, 1972
24. Sauerbrei W, Schumacher M: A bootstrap resampling procedure for model building application to the Cox regression model. Stat Med 11:2093-2109, 1992
25. Canellos GP, Skarin AT, Klatt MM, et al: The m-BACOD combination chemotherapy regimen in the treatment of diffuse large cell lymphoma. Semin Hematol 24:2-7, 1987 (suppl 1)
26. Shipp MA, Yeap BY, Harrington DP, et al: The m-BACOD combination chemotherapy regimen in large-cell lymphoma: Analysis of the completed trial and comparison with the m-BACOD regimen. J Clin Oncol 8:84-93, 1990
27. Dana BW, Dahlberg S, Miller TP, et al: m-BACOD treatment for intermediate-and high-grade malignant lymphomas: A Southwest Oncology Group phase II trial. J Clin Oncol 8:1155-1162, 1990
28. Shapiro CL, Yeap BY, Godleski J, et al: Drug-related pulmonary toxicity in non-Hodgkin's lymphoma: Comparative results with three different treatment regimens. Cancer 68:699-705, 1991
29. Gisselbrecht C, Haioun C, Lepage E, et al: Placebo controlled phase III trial of lenograstim (glycosylated recombinant human G-CSF) in aggressive non-Hodgkin's lymphoma. Leuk Lymphoma 25:289-300, 1997
30. Glick JH, Kim K, Earle J, et al: An ECOG randomized phase III trial of CHOP versus CHOP plus radiotherapy for intermediate grade early stage non-Hodgkin's lymphoma. Proc Am Soc Clin Oncol 14:391, 1995 (abstr)
31. Miller TP, Dahlberg S, Cassady JR, et al: Chemotherapy alone compared with chemotherapy plus radiotherapy for localized intermediate and high grade non-Hodgkin's lymphoma. N Engl J Med 339;21-26, 1998
32. Stoppa AM, Bouabdallah R, Chabannon C, et al: Intensive sequential chemotherapy with repeated blood stem-cell support for untreated poor-prognosis non-Hodgkin's lymphoma. J Clin Oncol 15;1722-1729, 1997
33. Shipp MA, Neuberg D, Janicek M, et al: High-dose CHOP as initial therapy for patients with poor prognosis aggressive non-Hodgkin's lymphoma: A dose-finding pilot study. J Clin Oncol 13:2916-2923, 1995
34. Tannock IF: False-positive results in clinical trials: Multiple significance tests and problem of unreported comparisons. J Natl Cancer Inst 88:206-207, 1996