Ethane sulfonate metabolite of alachlor: Assessment of oncogenic potential based on metabolic and mechanistic considerations

Toxicological Sciences

Volumn 55, Issue 1, 2000, Pages 36-43

  Heydens, William F ^a   Wilson, Alan G E ^a   Kraus, Lori J ^a   Hopkins II, William E ^a   Hotz, Kathy J ^a  

^a MONSANTO COMPANY   (United States)

Author keywords

Alachlor; Alachlor ethane sulfonate; Common mechanism; Metabolite; Oncogenic potential; Pharmacokinetics; Risk assessment

Indexed keywords

ALACHLOR; CARBON 14; HERBICIDE;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; CHEMICAL CARCINOGENESIS; CONTROLLED STUDY; FECES ANALYSIS; FEMALE; GENOTOXICITY; MALE; METABOLITE; NONHUMAN; ORGAN WEIGHT; RADIOACTIVITY; RAT; RISK ASSESSMENT; TOXICOKINETICS; URINARY EXCRETION;

EID: 0034103443     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/55.1.36     Document Type: Article

References (16)

1. Baker, D. B., Bushway, R. J., Adams, S. A., and Macomber, C. (1993). Immunoassay screens for alachlor in rural wells: False positives and an alachlor soil metabolite. Environ. Sci. Technol. 27, 562-564.
2. Baker, D. B., Wallrabenstein, L. K., Richards, R. P., and Barnett, J. D. (1994). Nitrates and Pesticides in Private Wells of Indiana. American Farm Bureau Federation.
3. Department of Agriculture, Trade and Consumer Protection (1994). 1994 Groundwater Survey for Alachlor in Southern Wisconsin. DATCP, Madison, WI.
4. Dietrich, D. (1993). Toxicological and pathological applications of proliferating cell nuclear antigen (PCNA), a novel endogenous marker tor cell proliferation. Crit. Rev. Toxicol. 23, 77-109.
5. Feng, P. C. C., Wilson, A. G. E., McClanahan, R. H., Patanella, J. E., and Wratten, S. J. (1990). Metabolism of alachlor by rat and mouse liver and nasal turbinate tissues. Drug Metab. Dispos. 18, 373-377.
6. Galand, P., and Degraef, C. (1989). Cyclin/PCNA immunostaining as an alternative to tritiated thymidine pulse labeling for marking S-phase cells in paraffin sections from animal and human tissues. Cell Tissue Kinet. 22, 383-392.
7. Heydens, W. F. (1999). Summary of toxicology studies with alachlor. J. Pesticide Sci. 24, 75-82.
8. Heydens, W. F., Siglin, J. C., Holson, J. F., and Stegeman, S. D. (1996a). Subchronic, developmental, and genetic toxicology studies with the ethane sulfonate metabolite of alachlor. Fundam. Appl. Toxicol. 33, 173-181.
9. Heydens, W. F., Wilson, A. G. E., Kier, L. D., Lau, H., Thake, D. C., and Martens, M. A. (1999). An evaluation of the carcinogenic potential of the herbicide alachlor to man. Human Exp. Toxicol. 18, 363-391.
10. Heydens, W. F., Wilson, A. G. E., Kraus, L. J., Hopkins, W. E., and Hotz, K. J. (1996b). Differences in the pharmacokinetics and toxicity of alachlor and its ethane sulfonate metabolite. The Toxicologist 30, 52 (271).
11. Holden, L. R., Graham, J. A., Whitmore, R. W., Alexander, W. J., Pratt, R. W., Liddle, S. K., and Piper, L. L. (1992). Results of the national alachlor well water survey. Environ. Sci. Technol. 26, 935-943.
12. Snedecor, G. W., and Cochran, W. G. (1967). Statistical Methods, 6th ed., pp. 223-226, 258-268. Iowa State University Press, Ames, Iowa.
13. Thake, D. C., Iatropoulos, M. J., Hard, G. C., Hotz, K. J., Wang, C-X., Williams, G. M., and Wilson, A. G. E. (1995). A study of the mechanism of butachlor-associated gastric neoplasms in Sprague-Dawley rats. Exp. Toxicol. Pathol. 47, 107-116.
14. U.S. EPA (Environmental Protection Agency) (1998). "Alachlor Reregistration Eligibility Decision (RED) Document." EPA 738-R-98-020, Case 0063.
15. Wilson, A. G. E., and Takei, A. S. (2000). Summary of toxicology studies with butachlor. J. Pesticide Sci. 25, 75-83.
16. Wilson, A. G. E., Thake, D. C., Heydens, W. F., Brewster, D. W., and Hotz, K. J. (1996). Mode of action of thyroid tumor formation in the male Long-Evans rat administered high doses of alachlor. Fundam. Appl. Toxicol. 33, 16-23.