Metal-catalyzed oxidation of brain-derived neurotrophic factor (BDNF): Analytical challenges for the identification of modified sites

Pharmaceutical Research

Volumn 17, Issue 2, 2000, Pages 190-196

  Jensen, Jana L ^a   Kolvenbach, Carl ^b   Roy, Suzanne ^b   Schöneich, Christian ^a  

^a UNIVERSITY OF KANSAS   (United States)

^b AMGEN INC   (United States)

Author keywords

Brain derived neurotrophic factor (BDNF); Cyanogen bromide (CNBr); Metal catalyzed oxidation (MCO); Methionine sulfoxide; Protein conformation; Quality control

Indexed keywords

ASCORBATE OXIDASE; BRAIN DERIVED NEUROTROPHIC FACTOR;

AMINO ACID ANALYSIS; ARTICLE; CONFORMATIONAL TRANSITION; COVALENT BOND; DRUG DEGRADATION; MASS SPECTROMETRY; OXIDATION; PEPTIDE MAPPING; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DEGRADATION;

AMINO ACID SEQUENCE; ANILINO NAPHTHALENESULFONATES; ASCORBIC ACID; BRAIN-DERIVED NEUROTROPHIC FACTOR; CATALYTIC DOMAIN; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COPPER; CYANOGEN BROMIDE; ENDOPEPTIDASES; FLUORESCENT DYES; METHIONINE; MOLECULAR SEQUENCE DATA; MOLECULAR WEIGHT; OXIDATION-REDUCTION; OXYGEN; PROTEIN CONFORMATION; PROTEIN DENATURATION; SEQUENCE ANALYSIS, PROTEIN; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; ULTRACENTRIFUGATION;

EID: 0034103193     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1007569431038     Document Type: Article

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